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In the mid-1990s, fentanyl was first introduced for widespread palliative use with the clinical introduction of the [[Duragesic]] patch, followed in the next decade by the introduction of the first quick-acting prescription formulations of fentanyl for personal use, the [[Actiq]] lollipop and [[Fentora]] buccal as well as through the delivery method of estradiol [[Mylan]] [[transdermal patches]]. {{As of|2012}} fentanyl was the most widely used synthetic opioid in clinical practice,<ref>{{cite web|url=http://livertox.nih.gov/FentanylAndAnalogues.htm|title=Fentanyl and Analogues}}</ref> with several new delivery methods now available, including a [[sublingual]] spray for cancer patients.<ref>{{cite web|url=http://www.centerwatch.com/drug-information/fda-approved-drugs/drug/1179/subsys-fentanyl-sublingual-spray|title=Subsys (fentanyl sublingual spray)}}</ref><ref>{{cite web|url=http://clinicaltrials.gov/ct2/show/NCT00538863 |title=Long Term Safety and Efficacy Study of Fentanyl Sublingual Spray for the Treatment of Breakthrough Cancer Pain - Full Text View |publisher=ClinicalTrials.gov |accessdate=2010-07-28}}</ref> In 2013, 1700 kilograms were used globally.<ref name=UN2015>{{cite book|title=Narcotic Drugs 2014|date=2015|publisher=INTERNATIONAL NARCOTICS CONTROL BOARD|isbn=9789210481571|page=21|url=https://www.incb.org/documents/Narcotic-Drugs/Technical-Publications/2014/Narcotic_Drugs_Report_2014.pdf|format=pdf}}</ref>
Fentanyl is [[recreational drug use|used recreationally]], whereby death is common.<ref name="Globalnews.ca-1">{{cite news|url=http://globalnews.ca/news/2159388/it-is-a-huge-issue-145-fentanyl-related-deaths-in-alberta-so-far-in-2015/|title=‘It is a huge issue’: 145 fentanyl-related deaths in Alberta so far in 2015|date=August 11, 2015|publisher=globalnews.ca|accessdate=16 November 2015}}</ref> Deaths have resulted from both recreational and improper medical use,
==Medical uses==
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