FCER1: Difference between revisions

The '''high-affinity IgE receptor''', also known as '''FcεRI''', or '''Fc epsilon RI''', is the high-[[Affinity (pharmacology)|affinity]] [[receptor (biochemistry)|receptor]] for the [[Fc region]] of [[immunoglobulin E]] (IgE), an [[antibody]] [[Isotype (immunology)|isotype]] involved in the [[allergy]] disorder and [[parasitism|parasites]] immunity. FcεRI is a [[tetrameric protein|tetramer]]ic receptor complex that binds Fc portion of the ε [[Immunoglobulin heavy chain|heavy chain]] of [[IgE]].<ref>{{Cite book|url=https://www.amazon.com/Robbins-Basic-Pathology-ebook/dp/B007OMFA6Q/ref=mt_kindle?_encoding=UTF8&me=|title=Robbins Basic Pathology|last=Kumar|first=Vinay|last2=Abbas|first2=Abul K.|last3=Aster|first3=Jon|date=2012-05-01|publisher=Saunders|edition=9|language=English}}</ref> It consists of one alpha (FcεRIα - antibody binding site), one beta (FcεRIβ - which amplifies the downstream signal), and two gamma chains (FcεRIγ - the site where the downstream signal initiates) connected by two disulfide bridges. It is constitutively expressed on [[mast cells]] and [[basophils]]<ref name="pmid11964662">{{cite journal | author = Pawankar R | title = Mast cells as orchestrators of the allergic reaction: the IgE-IgE receptor mast cell network | journal = Curr Opin Allergy Clin Immunol | volume = 1 | issue = 1 | pages = 3–6 |date=February 2001 | pmid = 11964662 | doi = 10.1097/00130832-200102000-00002| url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1528-4050&volume=1&issue=1&spage=3 | issn = }}</ref> and is inducible in eosinophils.