P6, P-6 or P.6 may refer to:
- P-6 Hawk, a 1927 American single-engine biplane fighter
- p6 protein, a protein providing nucleocapsid of HIV
- HAT-P-6, a star in the constellation Andromeda
- Integrated Truss Structure#P6, S6 trusses on the International Space Station
- Intel P6, a sixth generation x86 microprocessor microarchitecture
- Piaggio P.6, a 1927 Italian catapult-launched reconnaissance float plane
- PZL P.6, a 1930 Polish fighter
- Rover P6
- Period 6 of the periodic table