John Locke (1632–1704) was a 17th century English philosopher.
John Locke may also refer to:
- John Locke (Lost), fictional character on the American television show Lost
- John Locke (Canadian politician) (1825–1873), Nova Scotia Senator, 1867–1873
- John Locke (musician) (1943–2006), former member of the jazz-hard rock band Spirit
- John Locke (Massachusetts), member of the U.S. House of Representatives, 1823–1829
- John Locke (naturalist) (1792–1856)
- John Locke (poet) (1847–1889), Irish poet, novelist and journalist
- John Locke (MP), British Member of Parliament for Southwark, 1857–1880
- John Locke (author), American writer of contemporary crime fiction
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