Serious Business can refer to
- "Serious Business", a song from the album Uh-Huh by John Cougar Mellencamp and the B-side of "Pink Houses"
- Serious Business Records, a record label founded by Travis Harrison and Andy Ross
- SIRIUS Business, a commercial background music service of Applied Media Technologies Corporation
- Serious Business 2003, a translation company based in Bucharest, Romania.
This disambiguation page lists articles associated with the title Serious Business.
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