Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute.[11][12][13][14]
Allan Bradley | |
|---|---|
.jpg) Allan Bradley at the launch of the Shakespeare review, organised by Policy Exchange | |
| Born | Allan Bradley |
| Alma mater | University of Cambridge (BA, MA, PhD)[9] |
| Known for | Embryonic stem cells[10] |
| Awards |
|
| Scientific career | |
| Fields | Mouse genomics[2][3][4][5][6] |
| Institutions | |
| Thesis | Isolation characterisation and developmental potential of murine embryo-derived stem cells (1986) |
| Doctoral advisor | Martin Evans[7][8] |
| Website | sanger |
Education
editBradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD[15] degrees in genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans.[9][7]
Career
editFollowing his PhD, Bradley was appointed assistant professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988.[16] Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (preceded by John Sulston) to April 2010, succeeded by Michael Stratton.
Awards and honours
editBradley won a 1994 DeBakey Award[17] and was elected a Fellow of the Royal Society (FRS) in 2002. His certificate of election reads:
"Allan Bradley has made important contributions to the technique of mutation of endogenous genes in mice, an approach that has opened up a new era of research in biology. It is impossible to open an issue of a major journal nowadays without coming across an article that describes the consequences of mutating an endogenous gene in mice. The generation of these mice is based on concepts and techniques that can be traced back to experiments performed and published by Bradley fifteen years ago. In the years since, he has not only used ES cell technology to provide key information on the functions of many genes including several important tumour suppressor genes, but has also continued to improve and develop the techniques, technology, and tools for genetic manipulation in the mouse. Today, mice can be generated with changes as subtle as an alteration in a single nucleotide or as extensive as the deletion of millions of base pairs. These alterations will gain increasing importance in genetic experiments aimed at understanding the function of genes in the mammalian genome in the post genome era."[10]
References
edit- ^ "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 16 March 2015.
- ^ Donehower, L. A.; Harvey, M.; Slagle, B. L.; McArthur, M. J.; Montgomery Jr, C. A.; Butel, J. S.; Bradley, A. (1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours". Nature. 356 (6366): 215–221. Bibcode:1992Natur.356..215D. doi:10.1038/356215a0. PMID 1552940. S2CID 4348340.
- ^ Dalton, D.; Pitts-Meek, S.; Keshav, S.; Figari, I.; Bradley, A.; Stewart, T. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes". Science. 259 (5102): 1739–1742. Bibcode:1993Sci...259.1739D. doi:10.1126/science.8456300. PMID 8456300.
- ^ Guo, G.; Wang, W.; Bradley, A. (2004). "Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells". Nature. 429 (6994): 891–895. Bibcode:2004Natur.429..891G. doi:10.1038/nature02653. PMID 15215866. S2CID 2545884.
- ^ Kile, B. T.; Hentges, K. E.; Clark, A. T.; Nakamura, H.; Salinger, A. P.; Liu, B.; Box, N.; Stockton, D. W.; Johnson, R. L.; Behringer, R. R.; Bradley, A.; Justice, M. J. (2003). "Functional genetic analysis of mouse chromosome 11". Nature. 425 (6953): 81–86. Bibcode:2003Natur.425...81K. doi:10.1038/nature01865. PMID 12955145. S2CID 4409237.
- ^ "Mouse genomics – Allan Bradley laboratory". Wellcome Trust Sanger Institute. Archived from the original on 1 April 2010.
- ^ a b "Allan Bradley – Wellcome Trust Sanger Institute". Sanger.ac.uk. Archived from the original on 13 November 2013.
- ^ Watts, Geoff (2007). "Martin Evans: joint winner of 2007 Nobel Prize in medicine". The Lancet. 370 (9605): 2095. doi:10.1016/S0140-6736(07)61889-3. ISSN 0140-6736. PMID 18156018. S2CID 7800773.
- ^ a b "BRADLEY, Prof. Allan". Who's Who. Vol. 2014 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
- ^ a b "Certificate of election EC/2002/01: Allan Bradley". London: The Royal Society. Archived from the original on 3 September 2015. Retrieved 14 November 2013.
- ^ "Professor Allan Bradley: a decade at Sanger | Wellcome Trust". Wellcome.ac.uk. 15 June 2010. Archived from the original on 3 December 2010. Retrieved 4 April 2012.
- ^ "Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society – Wellcome Trust Sanger Institute". Sanger.ac.uk. Retrieved 4 April 2012.
- ^ Allan Bradley's publications indexed by the Scopus bibliographic database. (subscription required)
- ^ Kate Kelland (12 October 2011). "New stem cell method could end need for liver transplants". National Post.
- ^ Bradley, A. (1985). Isolation characterization and developmental potential of murine embryo-derived stem cells (PhD thesis). University of Cambridge.
- ^ "Searle Scholars Program: Allan Bradley (1988)". Searlescholars.net. Retrieved 4 April 2012.
- ^ "Bradley – DeBakey Excellence in Research Awards- Baylor College of Medicine, Houston, Texas". Bcm.edu. Archived from the original on 19 July 2012. Retrieved 4 April 2012.