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George Emil Palade

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George Emil Palade ForMemRS HonFRMS (Romanian pronunciation: [ˈdʒe̯ordʒe eˈmil paˈlade] ⓘ; November 19, 1912 – October 7, 2008) was a Romanian-American cell biologist. Described as "the most influential cell biologist ever",[3] in 1974 he was awarded the Nobel Prize in Physiology or Medicine along with Albert Claude and Christian de Duve. The prize was granted for his innovations in electron microscopy and cell fractionation which together laid the foundations of modern molecular cell biology,[3] the most notable discovery being the ribosomes of the endoplasmic reticulum – which he first described in 1955.[4][5][6][7][8]

George Emil Palade
Palade on a 2021 Romanian stamp
Born
George Emil Palade

(1912-11-19)November 19, 1912
Iași, Kingdom of Romania
DiedOctober 8, 2008(2008-10-08) (aged 95)
Del Mar, California, United States
NationalityRomanian, American
Alma materCarol Davila School of Medicine
Known for
Spouses
  • ​
    ​
    (m. 1941; died 1969)​
  • ​
    (m. 1970)​
Awards
Scientific career
FieldsCell biology
Institutions
Notable studentsGünter Blobel[2]

Palade also received the U.S. National Medal of Science in Biological Sciences for "pioneering discoveries of a host of fundamental, highly organized structures in living cells" in 1986, and was previously elected a Member of the U.S. National Academy of Sciences in 1961. In 1968 he was elected as an Honorary Fellow of the Royal Microscopical Society (HonFRMS)[9] and in 1984 he became a Foreign Member of the Royal Society (ForMemRS).[1]

Education and early life

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George Emil Palade was born on November 19, 1912, in Iași, Romania; his father was a professor of philosophy at the University of Iași and his mother was a high school teacher. Palade received his M.D. in 1940 from the Carol Davila School of Medicine in Bucharest.

Career and research

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Palade on a 2016 Romanian stamp

Palade was a member of the faculty at University of Bucharest until 1946, when he went to the United States[10] to do postdoctoral research. While assisting Robert Chambers in the Biology Laboratory of New York University, he met Professor Albert Claude.[11] He later joined Claude at the Rockefeller Institute for Medical Research.[10]

In 1952, Palade became a naturalized citizen of the United States. He worked at the Rockefeller Institute (1958–1973), and was a professor at Yale University Medical School (1973–1990), and University of California, San Diego (1990–2008). At UCSD, Palade was Professor of Medicine in Residence (Emeritus) in the Department of Cellular & Molecular Medicine, as well as a Dean for Scientific Affairs (Emeritus), in the School of Medicine at La Jolla, California.[12]

In 1970, he was awarded the Louisa Gross Horwitz Prize from Columbia University, together with Renato Dulbecco (winner of the 1975 Nobel Prize in Physiology or Medicine) "for discoveries concerning the functional organization of the cell that were seminal events in the development of modern cell biology",[13] related to his previous research carried out at the Rockefeller Institute for Medical Research.[14] His Nobel lecture, delivered on December 12, 1974, was entitled: "Intracellular Aspects of the Process of Protein Secretion",[15] published in 1992 by the Nobel Prize Foundation,[16][17] He was elected an Honorary member of the Romanian Academy in 1975. He received the Golden Plate Award of the American Academy of Achievement in 1975.[18] In 1981, Palade became a founding member of the World Cultural Council.[19] In 1985, he became the founding editor of the Annual Review of Cell and Developmental Biology.[20] In 1988 he was also elected an Honorary Member of the American-Romanian Academy of Arts and Sciences (ARA).

Palade was the first Chairman of the Department of Cell Biology at Yale University. Presently, the Chair of Cell Biology at Yale is named the "George Palade Professorship".

At the Rockefeller Institute for Medical Research, Palade used electron microscopy to study the internal organization of such cell structures as ribosomes, mitochondria, chloroplasts, the Golgi apparatus, and others. His most important discovery was made while using an experimental strategy known as a pulse-chase analysis. In the experiment Palade and his colleagues were able to confirm an existing hypothesis that a secretory pathway exists and that the Rough ER and the Golgi apparatus function together.[4]

He focused on Weibel-Palade bodies (a storage organelle unique to the endothelium, containing von Willebrand factor and various proteins) which he described together with the Swiss anatomist Ewald R. Weibel.[21]

Palade's coworkers and approach in the 1960s

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The following is a concise excerpt from Palade's Autobiography appearing in the Nobel Award documents[10]

In the 1960s, I continued the work on the secretory process using in parallel or in succession two different approaches. The first relied exclusively on cell fractionation, and was developed in collaboration with Philip Siekevitz, Lewis Joel Greene, Colvin Redman, David Sabatini, and Yutaka Tashiro; it led to the characterization of the zymogen granules and to the discovery of the segregation of secretory products in the cisternal space of the endoplasmic reticulum. The second approach relied primarily on radioautography, and involved experiments on intact animals or pancreatic slices which were carried out in collaboration with Lucien Caro and especially James Jamieson. This series of investigations produced a good part of our current ideas on the synthesis and intracellular processing of proteins for export. A critical review of this line of research is presented in the Nobel Lecture.[15]

One notes also that the Nobel Prize in Chemistry was awarded in 2009 to Venkatraman Ramakrishnan, Thomas A. Steitz, and Ada E. Yonath "for studies of the structure and function of the ribosome", discovered by George Emil Palade.[22]

Personal life

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He married Irina Malaxa (born in 1919, the daughter of industrialist Nicolae Malaxa) on June 12, 1941. The couple had two children: Georgia (born in 1943) and Theodore (born in 1949).[23] After his wife died in 1969, Palade married Marilyn Farquhar, a cell biologist at the University of California, San Diego.[24]

References

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  1. ^ a b "Fellowship of the Royal Society 1660–2015". London: Royal Society. Archived from the original on 2015-10-15.
  2. ^ "The Palade Symposium: Celebrating Cell Biology at Its Best". Molbiolcell.org. Retrieved on 2016-06-10.
  3. ^ a b "Prof. George Palade: Nobel prize-winner whose work laid the foundations for modern molecular cell biology". The Independent. 22 October 2008. Archived from the original on October 19, 2010. Retrieved 2011-02-09. Archived. (Internet Archive copy)
  4. ^ a b Farquhar, Marilyn G. (10 November 2012). "A Man for All Seasons: Reflections on the Life and Legacy of George Palade". Annual Review of Cell and Developmental Biology. 28 (1): 1–28. doi:10.1146/annurev-cellbio-101011-155813. ISSN 1081-0706. PMID 22831641. S2CID 23177212. Retrieved 25 March 2023.
  5. ^ Grens, Kerry (February 1, 2014). "Palade Particles, 1955". The Scientist.
  6. ^ Pollack, Andrew (October 9, 2008) George Palade, Nobel Winner for Work Inspiring Modern Cell Biology, Dies at 95. The New York Times
  7. ^ George E. Palade on Nobelprize.org  , accessed 11 October 2020
  8. ^ Palade, G. E. (2007). "Tribute to Professor George E. Palade". Journal of Cellular and Molecular Medicine. 11 (1): 2–3. doi:10.1111/j.1582-4934.2007.00018.x. ISSN 1582-1838. PMC 4401215. PMID 17367496.
  9. ^ "Honorary Fellows Past and Present". Royal Microscopical Society. Retrieved 5 June 2018.
  10. ^ a b c "George E. Palade – Autobiography". Nobelprize.org. 2008-10-07. Retrieved 2011-04-03.
  11. ^ "George E. Palade - Autobiography". 2006-07-16. Archived from the original on 2006-07-16. Retrieved 2019-08-16.
  12. ^ Professor George E. Palade – web page at the University of California at San Diego, School of medicine Archived March 30, 2004, at the Wayback Machine
  13. ^ "The 1974 Nobel Prize for Medicine". Nobelprize.org. Retrieved 2011-04-03.
  14. ^ Nobel Laureates Affiliated with The Rockefeller University. rockefeller.edu
  15. ^ a b "Nobel lecture". Nobelprize.org. 1974-12-12. Retrieved 2011-04-03.
  16. ^ The Nobel Prize Lecture of George E. Palade (Pdf 3.78 MB), (1974) The Nobel Foundation, ISBN 981-02-0791-3
  17. ^ Nobel Lectures in Physiology or Medicine Archived July 14, 2008, at the Wayback Machine
  18. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  19. ^ "About Us". World Cultural Council. Retrieved November 8, 2016.
  20. ^ Spudich, James A. (1994). "Preface". Annual Review of Cell Biology. 10. doi:10.1146/annurev.cb.10.111406.100001.
  21. ^ Weibel, ER; Palade, GE (1964). "New cytoplasmic components in arterial endothelia". Journal of Cell Biology. 23 (1): 101–112. doi:10.1083/jcb.23.1.101. PMC 2106503. PMID 14228505.
  22. ^ 2009 Nobel Prize in Chemistry, Nobel Foundation
  23. ^ "Memorandum regarding Nicolae Malaxa" (PDF). www.cia.gov. Central Intelligence Agency. April 30, 1949. p. 9. Retrieved October 1, 2024.
  24. ^ James D. Jamieson (November 8, 2008). "Obituary: "A tribute to George E. Palade". Journal of Clinical Investigation. 118 (11): 3517–3518. doi:10.1172/JCI37749. PMC 2575727. PMID 19065752.

Bibliography

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