The term mixed-blood in the United States is most often employed for individuals of mixed European and Native American ancestry.
Mixed blood may also refer to:
- Mixed Blood (album), a 2007 remix and cover album of songs originally by Gotye
- Mixed Blood (1916 film), a 1916 film by Charles Swickard
- Mixed Blood (1985 film), a 1985 film by Paul Morrissey
- Mixed Blood Theatre Company, a professional multiracial theatre company in Minneapolis, Minnesota