View source for Phineas Gage

{{Short description|American brain injury survivor (1823–1860)}}
{{About|the survivor of an iron bar through the head|the UK musical band|Phinius Gage}}
{{Use American English|date=August 2020}}
{{Use mdy dates|cs1-dates=ly|date=December 2016}}
{{Infobox person
|name         = Phineas P. Gage
|image        = Phineas Gage Cased Daguerreotype WilgusPhoto2008-12-19 EnhancedRetouched Color.jpg
|image_upright= 1.35
|caption      = Gage and his "constant companion"{{mdashb}}his inscribed tamping iron{{mdashb}}sometime after 1849, seen in the portrait (identified in 2009){{NoteTag|name=dags}} that "exploded the common image of Gage as a dirty, {{nobr|disheveled misfit"{{hsp}}{{ran|K}} }}
|birth_date   = July 9, 1823 (date uncertain)<!--uncertain instead of circa because we have no confirmation this is even approximately the right date-->
|birth_place  = [[Grafton County, New Hampshire]],{{NoteTag|name=birth_name}}<!--<<cite covers birth date and place, and discusses uncertainty of birthdate--> U.S.
|death_date   = {{death date and age|1860|05|21|1823|07|09}}<!--1860 is correct despite Harlow reporting 1861; see Macmillan (2000) p. 108 -->
|death_place  = [[San Francisco Bay Area]], California, U.S.
|death_cause  = [[Status epilepticus]]
|occupation   = {{hlist | Railroad construction foreman | [[Rock blasting|blaster]] | [[stagecoach]]&nbsp;driver}}
|spouse=None |children=None{{ran|M|p=39,319,327}}{{r|northstar}}<!--Please don't remove spouse, children even though values are None. It's frequently (though incorrectly) asserted that Gage had a wife and family, and since the correct info is easily highlighted here we may as well do that-->
|burial_place = [[Cypress Lawn Memorial Park]], California (skull in [[Warren Anatomical Museum]], Boston)
|known_for    = Personality change after brain&nbsp;injury
}}

'''Phineas P. Gage''' (1823{{ndash}}1860) was an American railroad [[construction foreman]] remembered for his improbable{{ran|B1|p=19}} survival of an accident in which a large iron rod was driven completely through his head, [[Frontal lobe injury|destroying much of his brain's left frontal lobe]], and for that injury's reported effects on his personality and behavior over the remaining 12 years of his life{{mdashb}}effects sufficiently profound that friends saw him (for a time at least) as "no longer Gage".

{{stack|float=right|[[File:Phineas gage - 1868 skull diagram.jpg|thumb|upright=0.48|right|alt=A diagram of the iron rod traveling through Gage's skull|The iron's path, per Harlow{{ran|H|p=21}}]]}}

Long known as the "American Crowbar Case"{{mdashb}}once termed "the case which more than all others is {{shy|cal|cu|lated}} to excite our wonder, impair the value of [[prognosis]], and even to subvert our [[physiology|{{shy|phys|i|o|log|i|cal}}]] doctrines"{{hsp}}{{r|campbell}}{{mdashb}}Phineas Gage influenced 19th-century discussion about the [[mind]] and brain, {{shy|par|tic|u|larly}} debate on [[cerebral localization|cerebral {{shy|local|i|za|tion}}]],{{wbo}}{{ran|M|p=ch7-9}}{{ran|B}} and was perhaps the first case to suggest the brain's role in {{shy|deter|min|ing per|son|al|ity}}, and that [[brain damage|damage to specific parts of the brain]] might induce specific mental changes.

Gage is a fixture in the curricula of [[neurology]], [[psychology]], and [[neuroscience]],{{wbo}}{{r|larner}}{{ran|M7|p=149}} one of "the great medical curiosities of all time"{{ran|M8}} and "a living part of the medical folklore"{{hsp}}{{ran|R|p=637}} frequently mentioned in books and scientific papers;{{ran|M|p=ch14}} he even has a minor place in popular culture.{{refn|[[#CITEREFM|Macmillan (2000)]], ch. 13; [[#CITEREFM1|Macmillan (2008)]], p. 830.}} Despite this celebrity, the body of established fact about Gage and what he was like (whether before or after his injury) is small,{{NoteTag|name=accounts_reliablesources}} which has allowed "the fitting of almost any theory [desired] to the small number of facts we have"{{hsp}}{{ran|M|p=290}}{{mdashb}}Gage acting as a "[[Rorschach test|Rorschach inkblot]]"{{hsp}}{{r|mazzoni}} in which proponents of various conflicting theories of the brain all saw support for their views. Historically, published accounts of Gage (including scientific ones) have almost always severely exaggerated and distorted his behavioral changes, frequently contradicting the known facts.

A report of Gage's physical and mental condition shortly before his death implies that his most serious mental changes were temporary, so that in later life he was far more functional, and socially far better adapted, than in the years immediately following his accident. A social recovery hypothesis suggests that his work as a [[stagecoach]] driver in Chile fostered this recovery by providing daily structure that allowed him to regain lost social and personal skills.

==Life==

===Background===

[[File:CavendishVermont 1869Map Beers AnnotatedPhineasGageLocations cropped.jpg|link=File:CavendishVermont_1869Map_Beers_AnnotatedPhineasGageLocations.jpg|thumb|right|upright=1.3|alt=A map|[[Cavendish (CDP), Vermont|Cavendish, Vermont]], 20 years after Gage's accident: {{smallcaps|(a)}}&nbsp;Region of the accident site (exact location uncertain); {{smallcaps|(t)}}&nbsp;Gage's lodgings, to which he was taken after his injury; {{smallcaps|(h)}}&nbsp;Harlow's home and [[wikt:surgery#English: doctor consulting|surgery]].{{NoteTag|name=steps_setting}} ]]

Gage was the first of five children born to Jesse Eaton Gage and Hannah Trussell (Swetland) Gage of [[Grafton County, New Hampshire]].{{NoteTag
|name=birth_name
|Macmillan{{ran|M|p=14-17,31n5,490-91}} discusses Gage's ancestry and early life. The birthdate July 9, 1823, is given by a Gage genealogy{{r|cv_gage}} without citation,{{ran|M|p=16}} but is consistent with agreement among contemporary sources{{r|anonymous_national_eagle}}{{r|background}} that Gage was 25 years old on the date of his accident, and with his age (36&nbsp;years) as given in undertaker's records after his death in May&nbsp;1860.{{ran|M|p=108-9}} Possible homes in childhood and youth are [[Lebanon, New Hampshire|Lebanon]] or nearby East Lebanon, [[Enfield, New Hampshire|Enfield]], and/or [[Grafton, New Hampshire|Grafton]] (all in [[Grafton County, New Hampshire]]), though Harlow refers to Lebanon in particular as Gage's "native place"{{hsp}}{{ran|H|p=10}} and "his home"{{hsp}}{{ran|H|p=12}} (likely that of his parents),{{ran|M|p=30}} to which Gage returned ten weeks{{ran|M2|p=C}} after his accident.
{{paragraph break}}
There is nothing to indicate what Gage's middle initial,{{thinsp}}''P'',{{hsp}}{{wbo}}{{r|background}}{{refn|[[#CITEREFM|Macmillan (2000)]], p. 490; [[#CITEREFM1|Macmillan (2008)]], p. 839 (fig.).}}{{ran|G1}}{{r|warren_index}} stood for.{{ran|M|p=490}} His mother's maiden name is variously given as ''Swetland, Sweatland,'' or ''Sweetland''.{{r|swetland}}
<!--end efn>>-->}} Little is known about his upbringing and education beyond that he was literate.{{wbo}}{{ran|M|p=17,41,90}}{{ran|M10|p=643}}

Physician [[John Martyn Harlow]], who knew Gage before his accident, described him as "a perfectly healthy, strong and active young man, twenty-five years of age, nervo-bilious temperament, five feet six inches [{{convert|5|ft|6|in|m|disp=output only}}] in height, average weight one hundred and fifty pounds [{{convert|150|lb|kg|disp=output only }}], possessing an iron will as well as an iron frame; muscular system unusually well developed{{mdashb}}having had scarcely a day's illness from his childhood to the date of [his] injury".{{ran|H|p=4}} (In the [[phrenology|pseudoscience of phrenology]], which was then just ending its vogue,{{r|cooter}} ''nervo-bilious'' denoted an unusual combination of "excitable and active mental powers" with "energy and strength [of] mind and body [making] possible the endurance of great mental and physical labor".){{wbo}}{{ran|M|p=346-47}}{{r|fowler|p=6}}

Gage may have first worked with explosives on farms as a youth, or in nearby mines and quarries.{{ran|M|p=17-18}} In July 1848 he was employed on construction of the [[Hudson River Railroad]] near [[Cortlandt, New York<!--<<NOT Cortland, New York -- that's a different town-->|Cortlandt Town, New York]],{{r|heart}}{{ran|M10|p=643}} and by September he was a [[Rock blasting|blasting]] foreman (possibly an independent contractor) on railway construction projects.{{ran|M|p=18-22,32n9}} His employers' "most efficient and capable foreman&nbsp;... a shrewd, smart business man, very energetic and persistent in executing all his plans of operation",{{ran|H|p=13-14}} he had even commissioned a custom-made [[wikt:tamping#English: fill|tamping iron]]{{mdashb}}a large iron rod{{mdashb}}for use in setting explosive charges.{{wbo}}{{ran|B1|p=5}}{{ran|M|p=25}}

===Accident===
[[File:RailroadCutCavendishVermontPresumedToBePhineasGageAccidentSite cropped.jpg|thumb|left|upright=1|link=File:RailroadCutCavendishVermontPresumedToBePhineasGageAccidentSite.jpg|alt=Refer to caption|Line of the [[Rutland Railroad|Rutland&nbsp;& Burlington Railroad]] passing through "[[cut (earthmoving)|cut]]" in rock south of Cavendish. Gage met with his accident while setting {{shy|ex|plo|sives}} to create either this cut or a similar one nearby.{{NoteTag|name=steps_setting}} ]]

[[File:BlastHoleCharged Vertical.png|thumb|right|upright=0.55|link=File:BlastHoleCharged.png|alt=A diagram of a tamping iron and explosive charge|Explosive charge ready for fuse to be lit. {{small caps|[[wikt:tamping#English: material|tamping]]}} (sand or clay) directs blast into {{shy|sur|round|ing}} rock.]]

On September 13, 1848, Gage was {{shy|direct|ing a work gang blast|ing rock while pre|par|ing the road|bed}} for the [[Rutland Railway|{{shy|Rut|land&nbsp;& Bur|ling|ton Rail|road}}]] south of the village of [[Cavendish (CDP), Vermont|{{shy|Cav|en|dish, Ver|mont}}]]. Setting a blast entailed boring a hole deep into an {{shy|out|crop}} of rock; adding [[blasting powder|{{shy|blast|ing pow|der}}]] and a fuse; then using the tamping iron to pack ("tamp") sand, clay, or other inert material into the hole above the powder in order to contain the blast's energy and direct it into surrounding rock.{{NoteTag
|name=steps_setting
|Macmillan gives background on the location and circumstances of the accident, and the steps in setting a blast.
The village of Cavendish (part of the ''town'' of Cavendish) was at the time called Duttonsville.
The blast hole, about {{convert|1+3/4|inch|cm|round=0.5}} in diameter and up to {{convert|12|feet|m|sigfig=1}} deep, might require three men working as much as a day to bore using hand tools. The labor invested in setting each blast, the judgment involved in selecting its location and the quantity of powder to be used, and the often explosive nature of employer-employee relations on this type of job, all underscore the significance of Harlow's statements that Gage had been a "great favorite" with his men, and that his employers had considered him "the most efficient and capable foreman in their employ" prior to the accident.{{wbo}}{{ran|M|p=13,22-29}}{{wbo}}{{ran|M7|p=151-52}}{{wbo}}{{ran|M2|p=A}}
<!--end efn>>-->}}

[[File:Simulated_Connectivity_Damage_of_Phineas_Gage_vanHorn_ProbablePaths.jpg|thumb|upright=1|left|alt=Refer to caption|{{shy|The "cone of un|cer|tain|ty" for the path taken by the tamping iron. Gage's mouth was open at the moment of the ex|plo|sion, and the front and back of his skull tem|po|rarily "hinged" apart as the iron entered from below, then were pulled back to|geth|er by the re|sil|ience of soft tissues once the iron had exited through the top of Gage's head.{{refn|name=ratiu_vanhorn|[[#CITEREFR|Ratiu et al.]], p. 639{{ndash}}40; [[#CITEREFV|Van Horn et al.]], pp. 4{{ndash}}5, 17}} }}]]

[[File:BringMeTheHeadOfPhineasGage KABOOM BoundlessAScienceComicsAnthology 2016 EJBarnes LBLee.png|thumb|right|upright=0.55 |alt=Refer to caption|Panel from ''Bring Me the Head of Phineas Gage'', a portrayal of Gage in popular culture{{r|bring_me}}]]

As Gage was doing this around 4:30&nbsp;p.m., his attention was attracted by his men working behind him.
Looking over his right shoulder, and {{shy|inad|vert|ent|ly}} bringing his head into line with the blast hole and tamping iron, Gage opened his mouth to speak; in that same instant the tamping iron sparked against the rock and (possibly because the sand had been omitted) the powder exploded. Rocketed from the hole, the tamping iron{{mdashb}}{{convert|1+1/4|inch|cm}} in diameter, {{convert|3|ft|7|in|1|spell=in}} long, and weighing {{convert|13+1/4|lb|kg}}{{mdashb}}entered the left side of Gage's face in an upward direction, just forward of the angle of the [[mandible|lower jaw]]. Continuing upward outside the [[maxilla|upper jaw]] and possibly fracturing the [[zygomatic arch|cheekbone]], it passed behind the left eye, through the left side of the brain, then completely out the top of the skull through the [[frontal bone]].{{wbo}}{{ran|B1|p=13-14}}{{ran|H|p=5}}{{wbo}}{{ran|M|p=25-29}}{{wbo}}{{r|ratiu_vanhorn}}{{wbo}}{{r|anonymous_mercury}}

Despite 19th-century references to Gage as the "American Crowbar Case",{{NoteTag
|{{r|smithW|p=54}}{{ran|T2}} Barker: "Harlow always refers to the bar by its proper title, as a tamping iron. Bigelow's reference to a crowbar&nbsp;... gave the case its nickname, which is still encountered today."{{hsp}}{{wbo}}{{ran|B|p=678}}
<!--end efn>>-->}} his tamping iron did not have the bend or claw {{shy|some|times asso|ci|at|ed}} with the term ''[[Crowbar (tool)|crowbar]];'' rather, it was simply a pointed cylinder something like a [[javelin]],{{ran|K}} round and fairly smooth:{{ran|H|p=5}}

{{blockquote|The end which entered [Gage's cheek] first is pointed; the taper being [eleven inches (28&nbsp;cm) long, ending in a {{1/4}}-inch (6&nbsp;mm) point]{{hsp}}{{nobr|{{ran|V|p=17}}...}} {{shy|cir|cum|stances}} to which the patient perhaps owes his life. The iron is unlike any other, and was made by a {{sic|{{shy|neigh|bo<!--<<DO NOT AMERICANISE THIS SPELLING. DON'T AMERICANIZE IT EITHER>>-->ur|ing}}|hide=y}} blacksmith to please the fancy of the owner.{{ran|B1|p=14}}
}}

The tamping iron landed point-first some {{convert|80|ft|m|round=5}} away,{{ran|M|p=29}}{{r|anonymous_mercury}}{{r|anonymous_national_eagle}} "smeared with blood and brain".{{ran|H|p=5}}

Gage was thrown onto his back and gave some brief [[convulsions]] of the arms and legs, but spoke within a few minutes, walked with little assistance, and sat upright in an oxcart for the {{convert|3/4|mi|km|adj=on}} ride to his lodgings in town.{{ran|H|p=5}}
(A possibly apocryphal contemporary newspaper report claimed that Gage, while en route, made an entry in his time-book{{snd}}the record of his crew's hours and wages.){{ran|L1|p=172}}
About 30 minutes after the accident, physician [[Edward H. Williams]] found Gage sitting in a chair outside the hotel and was greeted with "one of the great understatements of medical history":{{wbo}}{{ran|M5|p=244}}

{{blockquote|When I drove up he said, "Doctor, here is business enough for you." I first noticed the wound upon the head before I alighted from my carriage, the pulsations of the brain being very distinct. The top of the head appeared somewhat like an inverted funnel, as if some wedge-shaped body had passed from below upward. Mr. Gage, during the time I was examining this wound, was relating the manner in which he was injured to the bystanders. I did not believe Mr. Gage's statement at that time, but thought he was deceived. Mr. Gage persisted in saying that the bar went through his head. Mr.&nbsp;G. got up and vomited; the effort of vomiting pressed out about half a teacupful of the brain [through the exit hole at the top of the skull], which fell upon the floor.{{r|accident_excerpts}}
}}

Harlow took charge of the case around 6 p.m.:

{{blockquote|You will excuse me for remarking here, that the picture presented was, to one unaccustomed to [[battlefield medicine|military surgery]], truly terrific; but the patient bore his sufferings with the most heroic firmness. He recognized me at once, and said he hoped he was not much hurt. He seemed to be perfectly conscious, but was getting exhausted from the hemorrhage. His person, and the bed on which he was laid, were literally one [[wikt:gore#English: thickened|gore]] of blood.{{r|accident_excerpts}}}}

Gage was also swallowing blood, [[Hematemesis|which he regurgitated]] every 15 or 20 minutes.{{r|accident_excerpts}}

===Treatment and convalescence===
[[File:Nightcap BenjaminBell ASystemOfSurgery 7thEd1801 Vol VII Plate CVII Fig1.png|thumb|left|upright=0.55|alt=Refer to caption|A [[nightcap (garment)|nightcap]] used as a bandage]]

With Williams' assistance{{NoteTag
|Williams family lore holds that Harlow did not appear on the scene until two days after Gage's accident, but nonetheless "sought eventually to take the whole glory of the successful outcome" of the case, even though Williams "was given full credit by all those who knew of his connection" to it. However, these stories conflict with every other account of the case, including Williams' own.{{wbo}}{{ran|M|p=279-84}}{{r|butler}}
<!--end efn>>-->}} Harlow shaved the scalp around the region of the tamping iron's exit, then removed coagulated blood, small bone fragments, and "an [[ounce]] or more" of protruding brain. After probing for foreign bodies and replacing two large detached pieces of bone, Harlow closed the wound with adhesive straps, leaving it partially open for drainage;{{ran|M|p=60-61}} the entrance wound in the cheek was [[bandage]]d only loosely, for the same reason. A wet [[wikt:compress#English: folded cloth|compress]] was applied, then a nightcap, then further bandaging to secure these dressings. Harlow also dressed Gage's hands and forearms (which along with his face had been deeply burned) and ordered that Gage's head be kept elevated.

Late that evening Harlow noted, "Mind clear. Constant agitation of his legs, being alternately retracted and extended{{nbsp}}... Says he 'does not care to see his friends, as he shall be at work in a few days.{{'"}}{{hsp}}{{r|accident_excerpts}}

[[File:PhineasGage BostonPostStory.jpg|thumb|left|upright=1.2|alt=A newspaper article|The first known report of Gage's {{shy|ac|ci|dent, under|stat|ing the thick|ness of his tamp|ing iron (by confusing its diam|e|ter with its cir|cum|fer|ence) and over|stat|ing the iron's length and the damage to Gage's jaw.{{wbo}}{{r|anonymous_bostonpost}}{{ran|M|p=12}}{{refn|[[#CITEREFH1|Harlow (1848)]], p. 389; [[#CITEREFB1|Bigelow (1850)]], p. 21; [[#CITEREFH|Harlow (1868)]], p. 16; [[#CITEREFM|Macmillan (2000)]], pp. 36{{ndash}}37.
}} "[Gage's] fame is of the kind that is, and in his case literally so, thrust upon other|wise ordinary people", writes Malcolm Macmillan.{{ran|M|p=11}}
}} ]]

Despite his own optimism, Gage's convalescence was long, difficult, and uneven. Though recognizing his mother and uncle{{mdash}}summoned from [[Lebanon, New Hampshire]], 30 miles (50{{nbsp}}km) away{{mdashb}}{{ran|H|p=12}}{{ran|M|p=30}} on the morning after the accident, on the second day, he "lost control of his mind, and became decidedly delirious". By the fourth day, he was again "rational&nbsp;... knows his friends", and after a week's further improvement Harlow entertained, for the first time, the thought "that it was ''possible'' for Gage to recover&nbsp;... This improvement, however, was of short duration."{{hsp}}{{r|accident_excerpts}}

[[File:PhineasGage LifeMask.jpg|thumb|right|upright=0.75|alt=Refer to caption|The entry damage to Gage's left cheek, and the raised bone fragment in the exit area above his forehead, are visible in this plaster cast taken in late 1849.{{wbo}}{{NoteTag|name=mask}}]]
[[File:Phineas Gage Cased Daguerreotype WilgusPhoto2008-12-19 CroppedHeadOnly EnhancedRetouched Color.jpg|right|thumb|upright=0.75|"Disfigured yet still hand{{shy}}some".{{ran|T}} Note [[ptosis (eyelid)|ptosis]] of the left eye and scar on forehead. ]]

Beginning 12 days after the accident,{{ran|M|p=53}} Gage was semi-[[coma]]tose, "seldom speaking unless spoken to, and then answering only in monosyllables", and on the 13th day Harlow noted, "Failing strength&nbsp;... coma deepened; the [[Globe (human eye)|globe]] of the left eye became more protuberant, with ["fungus"{{mdashb}}[[Necrosis|deteriorated, infected tissue]]]<!--<<while in Harlow's day there was debate about the nature of such "fungus", and the term could be (and even today sometimes is) used to refer to living tissue ("fungus cerebri"), Macmillan OKF p283 makes clear that the reference here is to infected tissue-->{{ran|M|p=61,283}} pushing out rapidly from the internal [[canthus]] [as well as] from the wounded brain, and coming out at the top of the head." By the 14th day, "the exhalations from the mouth and head [are] horribly [[wikt:fetid#Adjective|fetid]]. Comatose, but will answer in monosyllables if aroused. Will not take nourishment unless strongly urged. The friends and attendants are in hourly expectancy of his death, and have his coffin and clothes in readiness. One of the attendants implored me not to do anything more for him, as it would only prolong his sufferings{{mdash}}that if I would only keep away and let him alone, he would die."{{hsp}}{{r|accident_excerpts}}

Galvanized to action, Harlow "cut off the fungi which were sprouting out from the top of the brain and filling the opening, and made free application of caustic [i.e. [[silver nitrate#medical|crystalline silver nitrate]]]{{ran|M|p=54}}{{ran|H1|p=392}} to them. With a scalpel I laid open the {{bracket|[[frontalis muscle]], from the exit wound down to the top of the nose}}{{ran|H1|p=392}} and immediately there were discharged eight ounces [250&nbsp;ml] of [[ill-conditioned pus]], with blood, and excessively fetid."{{hsp}}{{r|accident_excerpts}} ("Gage was lucky to encounter Dr. Harlow when he did", writes Barker. "Few doctors in 1848 would have had the experience with cerebral [[abscess]] with which Harlow left {{bracket|[[Jefferson Medical College]]}} and which probably saved Gage's life."{{hsp}}{{ran|B|p=679-80}} ''See [[#Factors favoring|§&nbsp;Factors favoring Gage's survival]], below.'')

On the 24th day, Gage "succeeded in raising himself up, and took one step to his chair". One month later, he was walking "up and down stairs, and about the house, into the [[wikt:piazza#English|piazza]]", and while Harlow was absent for a week Gage was "in the street every day except Sunday", his desire to return to his family in New Hampshire being "uncontrollable by his friends&nbsp;... he went without an overcoat and with thin boots; got wet feet and a chill".  He soon developed a fever, but by mid-November was "feeling better in every respect [and] walking about the house again". Harlow's prognosis at this point: Gage "appears to be in a way of recovering, if he can be controlled".{{r|accident_excerpts}}

By November 25 (10 weeks after his injury), Gage was strong enough to return to his parents' home in [[Lebanon, New Hampshire]], traveling there in a "close carriage" (an enclosed conveyance of the kind used for transporting the insane).{{ran|H|p = 12}}{{ran|M|p = 92}} Though "quite feeble and thin&nbsp;... weak and childish"{{r|jackson1849}}{{ran|M|p=93}}<!--"feeble and thin" is not quoted in Macmillan 2000, p. 93 (which gives only "weak and childish") but it's in the original JBS Jackson manuscript--> on arriving, by late December he was "riding out, improving both mentally and physically",{{ran|H2}} and by the following February he was "able to do a little work about the horses and barn, feeding the cattle etc. [and] as the time for ploughing came [i.e. about May or June] he was able to do half a day's work after that and bore it well". In August his mother told an inquiring physician that his memory seemed somewhat impaired, though slightly enough that a stranger would not notice.{{NoteTag|
{{r|jackson1849}}{{ran|M|p=ix,93-94}}
Macmillan{{ran|M|p=378}} speculates that memory impairment may have been the interpretation placed by Gage's family on his difficulty, as reported by Harlow, in concentrating on tasks {{See below|1={{section link||Early observations (1849–1852)}}.}}
<!--end efn>>-->}}

===Injuries===

In April 1849, Gage returned to Cavendish and visited Harlow, who noted at that time loss of vision, and [[ptosis (eyelid)|ptosis]], of the left eye,{{NoteTag
|Though the tamping iron's passage forced the left eye from its orbit by one-half its diameter, that eye retained "indistinct" vision until the tenth day after the accident, when vision was permanently lost.{{ran|H|p=6,8,13}} Ratiu et&nbsp;al. conclude that "the optic canal was spared&nbsp;... [the vision loss being] secondary to acute glaucoma or swelling of the optic nerve and compression against the rigid walls of the optic canal".{{ran|R|p=640}} Harlow added that Gage could "[[wikt:adduct#English: move midwise|adduct]] and [[wikt:depress#English: move downward|depress]] the globe, but [not] move it in any other direction".
<!--end efn>>-->}} a large scar on the forehead (from Harlow's draining of the abscess){{ran|H1|p=392}} and

{{blockquote|upon the top of the head&nbsp;... <!--a large unequal depression and elevation{{mdashb}}-->a quadrangular fragment of bone<!--, which was entirely detached from the frontal, and extending low down upon the forehead, being still-->{{nbsp}}... raised and quite prominent. Behind this is a deep depression, two inches by one and one-half inches [5{{nbsp}}by 4{{nbsp}}cm] wide, beneath which the pulsations of the brain can be perceived. Partial paralysis of the left side of the face. His physical health is good, and I am inclined to say he has recovered. Has no pain in head, but says it has a queer feeling which he is not able to describe.{{ran|H|p=12-13}}}}

Gage's rearmost left upper [[molar (tooth)|molar]], adjacent to the point of entry through the cheek, was also lost.{{NoteTag|
[[Osteological]] examination of the [[tooth socket]] confirms that this tooth was lost before Gage died, though it is unknown when; presumably it was either knocked out during the accident, or loosened so that it fell out later.{{ran|V|p=17}}
}}<!--<end efn-->
Though a year later some weakness remained,{{ran|M|p=93}}{{r|ama_standing}} Harlow wrote that "physically, the recovery was quite complete during the four years immediately succeeding the injury".{{ran|H|p=19}}

===New England and New York (1849{{ndash}}1852)===

[[File:Members of the Boston Society for Medical Improvement.jpg|thumb|left|upright=1.2|alt=Refer to caption|Bigelow presented Gage to the elite [[Boston Society for Medical Improvement|Boston Society for Medical Im&shy;prove&shy;ment]] in 1849. In this 1853 Society portrait, [[Oliver Wendell Holmes Sr.|Oliver Wendell Holmes]] is seated second from left.]]
[[File:39 William England - Barnum's museum, New York.jpg|thumb|upright=1|right|For a time Gage was "a kind of living museum exhibit" at [[Barnum's American Museum]] in New York City. ]]
[[File:VermontPatriotAndStateGazette 1852Aug12 DistinguishedArrivals including PhineasGage.jpg|thumb|upright=1|alt=A newspaper advertisement|{{shy|"Admittance {{frac|12|1|2}} cents" (equiv|a|lent to about ${{Inflation|US|0.125|r=0|1852}} in {{Inflation-year|US}}).{{Inflation/fn|US}} Gage briefly resumed exhib|it|ing just before going to Chile, possibly to help finance that move; this adver|tise|ment appeared August 1852 in [[Montpelier, Vermont]].{{wbo}}{{ran|L1|p=175}} }} ]]

In November 1849 [[Henry Jacob Bigelow]], the Professor of Surgery at [[Harvard Medical School]],{{ran|M1|p=828}} brought Gage to Boston for several weeks and, after satisfying himself that the tamping iron had actually passed through Gage's head, presented him to a meeting of the [[Boston Society for Medical Improvement]] and (possibly) to the medical school class.{{wbo}}{{ran|B1|p=20}}{{wbo}}{{ran|M|p=43,95}}{{wbo}}{{r|bsmi}}{{wbo}}{{NoteTag
|name=firsts
|Gage may have been one of the earliest examples of a patient entering a hospital primarily to further medical research rather than for treatment.{{r|yakovlev}} He also appears to have been one of the first patients exhibited in an entertainment venue, as opposed to in presentations before medical audiences.{{wbo}}{{r|hansen}}{{ran|M1|p=194n15}}
}}<!--end efn-->

Unable to reclaim his railroad job {{see below|1={{section link||Early observations (1849–1852)}}}} Gage was for a time "a kind of living museum exhibit"{{hsp}}{{r|raeburn}} at [[Barnum's American Museum]] in New York City. (This was not the later [[P. T. Barnum#Barnum circus|Barnum's circus]]; there is no evidence Gage ever exhibited with a troupe or circus, or on a fairground.){{refn| [[#CITEREFB2|Bigelow (1868)]]; [[#CITEREFH|Harlow (1868)]], p. 14; [[#CITEREFM|Macmillan (2000)]], pp. 14,98{{ndash}}99; [[#CITEREFM10|Macmillan&nbsp;& Lena]], pp. 643{{ndash}}44.}}{{NoteTag|name=firsts}} Advertisements have also been found for public appearances by Gage{{mdashb}}which he may have arranged and promoted himself{{mdashb}}in New Hampshire and Vermont,{{ran|M10|p=643-44}} supporting Harlow's statement that Gage made public appearances in "most of the larger New England towns".{{ran|H|p=14}}{{ran|M1|p=829}} (Years later Bigelow wrote that Gage had been "a shrewd and intelligent man and quite disposed to do anything of that sort to turn an honest penny", but gave up such efforts because "[that] sort of thing has not much interest for the general public".){{wbo}}{{ran|B2}}{{wbo}}{{r|bennett|p=28}}{{wbo}}{{ran|M10|p=643-44}}
For about 18 months, he worked for the owner of a [[stable]] and coach service in [[Hanover, New Hampshire]].{{wbo}}{{ran|H|p=14}}{{ran|M|p=101}}

===Chile and California (1852{{ndash}}1860)===

{{Quote box |salign=right|align=left|width=22em
|quote = {{shy|Phineas was accustomed to entertain his little nephews and nieces with the most fabulous recit|als of his wonder|ful feats and hair-breadth escapes, without any found|at|ion except in his fancy. He con|ceived a great fondness for pets and souve|nirs, espe|cial|ly for children, horses and dogs{{mdashb}}only exceeded by his attach|ment for his tamping iron, which was his constant com|pan|ion during the remainder of his life.}}
|author = [[J. M. Harlow]] (1868){{ran|H|page=340}}
}}

In August 1852, Gage was invited to Chile to work as a long-distance [[stagecoach]] driver there, "caring for horses, and often driving a coach heavily laden and drawn by six horses" on the [[Valparaíso]]{{ndash}}[[Santiago, Chile|Santiago]] route.{{ran|M|p=103-4}}{{ran|H|p=14}} After his health began to fail in mid-1859,{{wbo}}{{ran|H|p=14-15}}{{NoteTag
|name=death
|Gage's death and original burial are discussed by Macmillan.{{wbo}}{{ran|M|p=108-9}}{{wbo}}{{ran|M2|p=D§corrections}}<!--SOURCE NOTE: Macmillan 2000 p. 108 says "the Interment Records of the Laurel Hill Cemetery give the date of death of 'Phineas B. Gage' as 20 May 1860 and the burial date as 23 May 1860"; however, in the "Phineas Gage Information Page -- Corrections to An Odd Kind of Fame" (https://www.uakron.edu/gage/book.dot) Macmillan corrected himself: "p. 108, para 2: The year of Gage's death is 1860, but the only other date on the records is 23rd. May for the funeral/interment".--> Harlow gives Gage's date of death as May&nbsp;21, 1861,{{ran|H|p=15}} but because bound, consecutive interment records{{r|anonymous_ngray}} show that Gage was buried May&nbsp;23, 1860,{{ran|M|p=122n17}} Macmillan concludes that May&nbsp;21, ''1860'' is the correct death date;{{wbo}}{{ran|M|p=122n15}}{{ran|M10|p=646}} this is confirmed by a contemporary obituary.{{r|deaths}} (Harlow's informant was Gage's mother;{{ran|H|p=15}}{{ran|M10|p=646}} Macmillan{{ran|M|p=376}} points out that the 1861 date, when combined with Gage's recorded age at death{{mdashb}}36 years plus an unspecified number of months{{mdashb}}obscures the fact that Gage was born just a few months after his parents' April&nbsp;27, 1823 marriage.) This implies that certain other dates Harlow gives for events late in Gage's life{{mdashb}}his move from Chile to San Francisco and the onset of his convulsions{{mdashb}}must also be mistaken, presumably by the same one year; this article follows Macmillan{{ran|M|p=122n15}} in correcting those dates, each of which carries this annotation.
<!--end efn>>-->}} he left Chile for San Francisco, arriving (in his mother's words) "in a feeble condition, having failed very much since he left New Hampshire&nbsp;... Had many ill turns while in Valparaiso, especially during the last year, and suffered much from hardship and exposure." In San Francisco he recovered under the care of his mother and sister,{{ran|H|p=15}} who had relocated there from New Hampshire around the time he went to Chile.{{ran|M|p=103-4}} Then, "anxious to work", he found employment with a farmer in [[Santa Clara County, California|Santa Clara]].{{ran|H|p=15}}

In February 1860,{{NoteTag|name=death}} Gage began to have [[epileptic seizure]]s. He lost his job, and (wrote Harlow) as the seizures increased in frequency and severity he "continued to work in various places [though he] could not do much".{{wbo}}{{ran|M|p=14}}{{ran|H|p=16}}

===Death and exhumation===

[[File:NewHampshireStatesman 1860July21 Deaths PhineasPGage.jpg|left|thumb|upright=1.2|alt=A newspaper article listing the death of Gage|''New Hampshire Statesman'', {{nobr|July 21,}} 1860{{wbo}}{{r|deaths}}]]

On May 18, 1860, Gage "left Santa Clara and went home to his mother. At 5&nbsp;o'clock, A.M., on the 20th, he had a severe {{shy|con|vul|sion}}. The family physician was called in, and [[bloodletting|bled]] him. The {{shy|con|vul|sions}} were repeated frequently during the {{shy|suc|ceed|ing}} day and night,"{{hsp}}{{ran|H|p=15}} and he died in ''[[status epilepticus|status {{shy|epi|lep|ti|cus}}]]'',{{ran|M2|p=E}} in or near San Francisco,{{NoteTag
|Where precisely Gage died is uncertain. Harlow states that Gage "went home to his mother" before he died, but the US census for June{{nbsp}}1, 1860 (seven days after Gage's death) lists as empty the San Francisco house shared by Hannah Gage, her daughter (Gage's sister) Phebe, Phebe's husband David Dustin Shattuck, and Phebe and David's young son Frank. Instead, Hannah, Phebe, and Frank (but not D.{{nbsp}}D. Shattuck, who sometimes traveled on business) were listed as living in the home of physician William Jackson Wentworth, across [[San Francisco Bay]] in what is now [[Oakland]]. The family's connection to Wentworth is uncertain, but it may be related to the fact that Frank was deaf; it is also possible Wentworth had met Gage when Gage visited Boston in 1849.{{wbo}}{{ran|M2|p=B}}{{ran|L1|p=194n16}}
<!--end efn-->}}
late on May&nbsp;21, 1860. He was buried in San Francisco's [[Lone Mountain Cemetery]].{{wbo}}{{NoteTag|name=death}}

[[File:JacksonJBS A descriptive catalogue of the Warren Anatomical Museum 1870 frontispiece 623x1024.jpg|thumb|right|upright=1|alt=Refer to caption|{{shy|"[T]he mother and friends, waiving the claims of personal and private affec|tion, with a mag|na|nim|ity more than praise|worthy, at my request have cheer|fully placed this skull in my hands, for the benefit of science." Gage's skull (sawed to show inte|rior) and iron, photo|graphed for Harlow in 1868.}}{{wbo}}{{refn|[[#CITEREFH|Harlow (1868)]], p. 21; [[#CITEREFM|Macmillan (2000)]], pp. 26,115,479{{ndash}}80}} ]]

[[File:DailyAltaCalifornia SanFrancisco 1867Dec25 p2c4 ADepartingSupervisor.jpg|left|thumb|upright=1.2|alt=A newspaper article|Gage's brother-in-law (a [[Members of the San Francisco Board of Supervisors#12 members elected by district (1856–1899)|San {{shy|Fran|cis|co city offi|cial}}]]) and his {{shy|fam|i|ly per|son|al|ly de|liv|ered}} Gage's skull and iron to Harlow.{{wbo}}{{ran|M10|p=646}}{{r|departing}} ]]

In 1866, Harlow (who had "lost all trace of [Gage], and had well nigh abandoned all {{shy|ex|pec|ta|tion}} of ever hearing from him again") somehow learned that Gage had died in California, and made contact with his family there. At Harlow's request the family had Gage's skull exhumed, then personally delivered it to Harlow,{{wbo}}{{ran|M|p=108-11}}{{ran|H|p=15-16}}{{ran|M10|p=646}} who was by then a prominent physician, {{shy|busi|ness|man,}} and civic leader in [[Woburn, Massachusetts]].{{wbo}}{{ran|M|p=351-64}}{{ran|M7}}

About a year after the accident, Gage had given his tamping iron to Harvard Medical School's [[Warren Anatomical Museum]], but he later reclaimed it{{wbo}}{{ran|B1|p=22n}}{{r|anonymous_bmsj1869_1}}{{ran|M|p=46-47}} and made what he called "my iron bar"{{hsp}}{{ran|M10|p=644}}{{ran|G1}} his "constant companion during the remainder of his life";{{NoteTag
|name=memo
|{{ran|H|p=13}} The tamping iron appears to have passed between the Warren Museum and Gage several times. Gage originally gave it to the Museum in early 1850, yet he had it with him when he briefly resumed exhibiting just before going to Chile in 1852. Two years later he was asking for it again: the Museum's files hold a note reading, "3106{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}Mr. B.{{nbsp}}R. Sweatland{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}Please deliver my iron bar to the bearer{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}P.{{nbsp}}P. Gage{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}Aug 26th, [18]54". Benjamin Richards Sweetland (or Sweatland), a second cousin of Gage's mother, emigrated from New York to California in the 1850s. Presumably Gage either gave or sent this note to Sweetland, who used it to retrieve from the Museum the tamping iron, which he then took, or forwarded, to Gage in Valparaiso. The ''3106'', in a different hand, is the tamping iron's number in [[J.B.S. Jackson]]'s 1870 catalog of the Museum.{{wbo}}{{ran|L1|p=176}}{{ran|G1}}
}}<!--<<end efn-->
now it too was delivered by Gage's family to Harlow.{{ran|M10|p=646}} (Though some accounts assert that Gage's iron had been buried with him, there is no evidence for this.){{wbo}}{{ran|M10|p=647}}{{ran|L1|p=177}} After studying them for a triumphal{{ran|L1|p=178}} 1868 retrospective paper on Gage{{ran|H|p=3}} Harlow redeposited the iron{{mdashb}}this time with the skull{{mdashb}}in the Warren Museum, where they remain on display today.{{r|warren_phineas_gage}}

The tamping iron bears the following inscription, commissioned by Bigelow in conjunction with the iron's original deposit in the Museum{{r|anonymous_bmsj1869_1}} (though the date given for the accident is one day off):

{{blockquote|This is the bar that was shot through the head of Mr Phinehas{{sup|[sic]}} P.&nbsp;Gage at Cavendish Vermont Sept&nbsp;14,{{sup|[sic]}} 1848. He fully recovered from the injury&nbsp;& deposited this bar in the Museum of the Medical College of Harvard University.{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}Phinehas P. Gage{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}Lebanon Grafton&nbsp;Cy {{nowrap|N{{ndash}}H}}{{nbsp}}{{bullet}}{{thinsp}}{{thinsp}}Jan&nbsp;6 1850{{r|WAM03106}}<!--there's no period at the end of the inscription, so omitting that even though this is the end of the article sentence containing this quotation-->
}}

The date ''Jan 6 1850'' falls within the period during which Gage was in Boston under Bigelow's observation.{{wbo}}{{ran|B1|p=20}}{{ran|H|p=4n}}{{ran|M|p=43}}

In 1940 Gage's headless remains were moved to [[Cypress Lawn Memorial Park]] as part of a mandated relocation of San Francisco's cemeteries to outside city limits {{crossreference|(see [[San Francisco cemetery relocations]])}}.{{wbo}}{{ran|M|p=119-20}}{{r|proctor}}
<imagemap>
File:PhineasGage BurialRecord GageEntry.jpg|thumb|upright=3|center|alt=Refer to caption|Excerpt from record book, [[Lone Mountain Cemetery]], San Francisco, reflecting the May&nbsp;23, 1860 interment of {{nobr|''Phineas B.{{sup|[sic]}} Gage''}} by undertakers [[N. Gray & Company|N.&nbsp;Gray&nbsp;& Co.]]{{NoteTag|name=death}}<br />''(Position pointer over writing for transcription; click for full page.)''
rect    0 0  290 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Date of Burial: 1860 May 23]]
rect  291 0  945 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Name: Phineas B.(sic) Gage]]
rect  946 0 1190 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Age (yrs mos ds): 36]]
rect 1191 0 1500 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Nativity: New Hampshire]]
rect 1500 0 1900 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Disease: Epilepsy]]
rect 1901 0 2280 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Place of Burial (tier grave plot): Vault]]
rect 2281 0 2400 387 [[:File:PhineasGage BurialRecord FullPage.jpg|Undertaker: Gray]]
</imagemap>
{{Clear}}

==Mental changes and brain damage==

[[File:John-m-harlow cropped.jpg|thumb|right|upright=1.0|link=File:John-m-harlow.jpg|alt=Refer to caption|"I [[wikt:dress#English: treat wound|dressed]] him, God healed him", wrote Dr. [[John Martyn Harlow|J.&nbsp;M. Harlow]], who attended Gage after the "rude missile had been shot through his brain"{{r|eliot}} and obtained his skull for study after his death. Shown here in later life, Harlow's interest in [[phrenology|{{shy|phre|nol|o|gy}}]] prepared him to accept that Gage's injury had changed his behavior.{{refn|[[#CITEREFH|Harlow (1868)]], p. 20; [[#CITEREFB|Barker]], p. 672}} ]]

[[File:Henry Jacob Bigelow c1854 cropped.jpg|thumb|right|upright=1.0|link=File:Henry_Jacob_Bigelow_c1854.jpg|alt=Refer to caption|"The leading feature of this case is its {{shy|im|prob|a|bil|ity}}", wrote Harvard's Prof. [[Henry Jacob Bigelow|H.&nbsp;J. Big{{shy}}e{{shy}}low]] (seen here in 1854). His anti-[[cerebral localization|{{shy|localiz|a|tion|ist}}]] training pre{{shy}}dis{{shy}}posed him to minimize Gage's behavioral changes.{{ran|B|p=672}}]]

Gage may have been the first case to suggest the brain's role in determining personality and that damage to specific parts of the brain might induce specific personality changes,{{refn|{{ran|M|p=1,378}}{{ran|M2|p=C}}{{r|cobb1940|p=1347}}{{r|cobb1943|p=56}}{{ran|K2|p=abstr}}}} but the nature, extent, and duration of these changes have been difficult to establish.{{ran|M|p=89}}{{ran|M10|p=652-55}} Only a handful of sources give direct information on what Gage was like (either before or after the accident),{{NoteTag|name=accounts_reliablesources}} the mental changes published after his death were much more dramatic than anything reported while he was alive,{{ran|M|p=375-76}} and few sources are explicit about the periods of Gage's life to which their various descriptions of him (which vary widely in their implied level of functional impairment) are meant to apply.{{wbo}}{{ran|M10|p=646-47}}

===Early observations (1849–1852)<span id="Early observations"></span>===

Harlow ("virtually our only source of information" on Gage, according to psychologist Malcolm Macmillan){{ran|M|p=333}}{{NoteTag|name=accounts_reliablesources}} described the pre-accident Gage as hard-working, responsible, and "a great favorite" with the men in his charge, his employers having regarded him as "the most efficient and capable foreman in their employ"; he also took pains to note that Gage's memory and general intelligence seemed unimpaired after the accident, outside of the delirium exhibited in the first few days.{{ran|M|p=30,91}} Nonetheless these same employers, after Gage's accident, "considered the change in his mind so marked that they could not give him his place again":

{{blockquote|{{shy|The equi|lib|rium or balance, so to speak, between his intel|lec|tual fac|ul|ties and animal pro|pen|si|ties, seems to have been destroyed. He is fitful, irreverent, indulging at times in the grossest profanity (which was not pre|vi|ous|ly his custom), manifesting but little deference for his fellows, impatient of restraint or advice when it conflicts with his desires, at times per|ti|na|cious|ly obstinate, yet capricious and vac|il|lat|ing, devising many plans of future operations, which are no sooner arranged than they are abandoned in turn for others appearing more feasible. A child in his intel|lec|tu|al capacity and man|i|fes|ta|tions, he has the animal passions of a strong man. Previous to his injury, although untrained in the schools, he possessed a well-balanced mind, and was looked upon by those who knew him as a shrewd, smart {{sic|hide=y|business <!--<<TWO WORDS, NOT "businessman">>-->man}}, very energetic and persistent in executing all his plans of operation. In this regard his mind was radically changed, so decidedly that his friends and acquaint|ances said he was "no longer Gage."}}{{ran|H|p=13-14}}}}

This description ("now routinely quoted", says Kotowicz){{ran|K2|p=125}} is from Harlow's observations set down soon after the accident,{{wbo}}{{ran|M|p=90,375}}{{ran|M10|p=646-49}} but Harlow{{mdashb}}perhaps hesitant to describe his patient negatively while he was still alive{{ran|M|p=375-76}}{{mdashb}}delayed publishing it until 1868, after Gage had died and his family had supplied "what we so much desired to see" (as Harlow termed Gage's skull).{{ran|H|p=16}}

In the interim, Harlow's 1848 report, published just as Gage was emerging from his convalescence, merely hinted at psychological symptoms:{{ran|M|p=169}}

{{blockquote|The mental manifestations of the patient, I reserve to a future communication. I think the case&nbsp;... is exceedingly interesting to the enlightened physiologist and intellectual philosopher.{{ran|H1|p=393}}}}

[[File:AmericanPhrenologicalJournal 1851April AMostRemarkableCase PhineasGage.png|thumb|left|upright=1.2| {{shy|alt=A newspaper article|"Before the in|jury he was quiet and re|spect|ful." 1851 report, ap|par|ently based on infor|ma|tion from Harlow, coun|ter|ing Bigelow's claim that Gage was mentally unchanged.}}]]

But after Bigelow termed Gage "quite recovered in faculties of body and mind" with only "inconsiderable disturbance of function",{{ran|B1|p=13-14}} a rejoinder in the ''American Phrenological Journal''{{mdashb}}

{{blockquote|That there was no difference in his mental manifestations after the recovery [is] ''not'' true&nbsp;... he was gross, profane, coarse, and vulgar, to such a degree that his society was intolerable to decent people.{{r|amer_phren}}}}

{{mdashb}}was apparently based on information anonymously supplied by Harlow.{{ran|M|p=350-51}} Pointing out that Bigelow gave extensive verbatim quotations from Harlow's 1848 papers, yet omitted Harlow's promise to follow up with details of Gage's "mental manifestations", Barker explains Bigelow's and Harlow's contradictory evaluations (less than a year apart) by differences in their educational backgrounds, in particular their attitudes toward [[cerebral localization]] (the idea that different regions of the brain are specialized for different functions) and [[phrenology]] (the nineteenth-century [[pseudoscience]] that held that talents and personality can be inferred from the shape of a person's skull):

{{blockquote|Harlow's interest in phrenology prepared him to accept the change in [Gage's] character as a significant clue to cerebral function which merited publication. Bigelow had [been taught] that damage to the cerebral hemispheres had no intellectual effect, and he was unwilling to consider Gage's deficit significant&nbsp;... The use of a single case [including Gage's] to prove opposing views on phrenology was not uncommon.{{ran|B|p=672,676,678,680}} }}

A reluctance to ascribe a biological basis to "higher mental functions" (functions{{mdashb}}such as language, personality, and moral judgment{{mdashb}}beyond the merely [[sensory processing|sensory]] and [[motor control|motor]]) may have been a further reason Bigelow discounted the behavioral changes in Gage which Harlow had noted.{{wbo}}{{ran|M|p=169-70}}{{ran|M1|p=838}} {{Crossreference|(See [[Mind–body dualism]].)}}

===Later observations (1858{{ndash}}1859)===
[[File:PhineasGage 1854Memo ToneCorrected.jpg|thumb|upright=1.3|alt=A handwritten note|"Please deliver my iron bar to the bearer". While in Chile, Gage had his relative B.{{nbsp}}R. Swee<!--the correct spelling is Sweetland, despite the note reading Sweatland-->tland retrieve the tamping iron from Harvard's Warren Anatomical Museum.{{NoteTag|name=memo}}]]

In 1860, an American physician who had known Gage in Chile in 1858 and 1859 described him as still "engaged in stage driving [and] in the enjoyment of good health, with no impairment whatever of his mental faculties".{{wbo}}{{r|hamilton}}{{ran|M10|p=648}} Together with the fact that Gage was hired by his employer in advance, in New England, to become part of the new coaching enterprise in Chile,{{wbo}}{{ran|H|p=15}}{{ran|M10|p=655}} this implies that Gage's most serious mental changes had been temporary, so that the "fitful, irreverent&nbsp;... capricious and vacillating" Gage described by Harlow immediately after the accident became, over time, far more functional and far better adapted socially.{{wbo}}{{ran|M1|p=831}}{{ran|M10|p=642,655}}

Macmillan writes that this conclusion is reinforced by the responsibilities and challenges associated with stagecoach work such as that done by Gage in Chile, including the requirement that drivers "be reliable, resourceful, and possess great endurance. But above all, they had to have the kind of personality that enabled them to get on well with their passengers."{{hsp}}{{wbo}}{{r|austin|p=127-32}}{{ran|M|p=104-6}}{{ran|M10|p=644-45}} A day's work for Gage meant "a 13-hour journey over 100 miles [160{{nbsp}}km] of poor roads, often in times of political instability or frank revolution. All this{{mdashb}}in a land to whose language and customs Phineas arrived an utter stranger{{mdashb}}militates as much against permanent disinhibition [i.e. an inability to plan and self-regulate] as do the extremely complex sensory-motor and cognitive skills required of a coach driver."{{hsp}}{{wbo}}{{ran|M10|p=645}}{{ran|M1|p=831}}{{r|nyt_additional}} (An American visitor wrote: "The departure of the coach was always a great event at Valparaiso{{mdashb}}a crowd of ever-astonished Chilenos assembling every day to witness the phenomenon of one man driving six horses."){{r|merwin|p=73}}

===Social recovery<span id="Social recovery hypothesis"></span>===
[[File:Concord_Stagecoach_number_251.JPG|upright=1.3|thumb|right|alt=Refer to caption|A [[Concord coach]], likely the type driven by Gage in Chile{{refn|[[#CITEREFM|Macmillan (2000)]], pp. 104, 121n13; [[#CITEREFM10|Macmillan&nbsp;& Lena]], p. 645}} ]]

Macmillan writes that this contrast{{mdashb}}between Gage's early, versus later, post-accident behavior{{mdashb}}reflects his "[gradual change] from the commonly portrayed impulsive and uninhibited person into one who made a reasonable 'social recovery{{'"}},{{r|jarrett1}} citing persons with similar injuries for whom "someone or something gave enough structure to their lives for them to relearn lost social and personal skills":{{ran|M1|p=831}}

{{blockquote|{{shy|Phineas' survival and reha|bil|i|ta|tion dem|on|strated a theory of recovery which has influ|enced the treat|ment of frontal lobe damage today. In modern treat|ment, adding struc|ture to tasks by, for example, mentally vis|u|al|is|ing a written list, is con|sid|ered a key method in coping with frontal lobe damage.{{ran|M4}} }}}}

According to contemporary accounts by visitors to Chile,{{wbo}}{{r|merwin}}{{r|nyt_additional}}{{ran|M1|p=831}}{{ran|M10|p=645}} Gage would have had to

{{blockquote|rise early in the morning, prepare himself, and groom, feed, and harness the horses; he had to be at the departure point at a specified time, load the luggage, charge the fares and get the passengers settled; and then had to care for the passengers on the journey, unload their luggage at the destination, and look after the horses. The tasks formed a structure that required control of any impulsiveness he may have had.{{ran|M9}}}}

En route (Macmillan continues):

{{blockquote|much foresight was required. Drivers had to plan for turns well in advance, and sometimes react quickly to manoeuvre around other coaches, wagons, and ''[[barouche|birlochos]]'' travelling at various speeds{{nbsp}}... Adaptation had also to be made to the physical condition of the route: although some sections were well-made, others were dangerously steep and very rough.}}

Thus Gage's stagecoach work{{mdashb}}"a highly structured environment in which clear sequences of tasks were required [but within which] contingencies requiring foresight and planning arose daily"{{mdashb}}resembles rehabilitation regimens first developed by Soviet neuropsychologist [[Alexander Luria]] for the reestablishment of self-regulation in World War&nbsp;II soldiers suffering frontal lobe injuries.{{wbo}}{{ran|M10|p=645,651-52,655}}{{ran|L2}}

A neurological basis for such recoveries may be found in emerging evidence "that damaged [[Neural pathway|[neural] tracts]] may re-establish their original connections or build alternative pathways as the brain recovers" from injury.{{r|jarrett1}} Macmillan adds that if Gage made such a recovery{{mdashb}}if he eventually "figured out how to live" (as Fleischman put it){{ran|F|p=75}} despite his injury{{mdashb}}then it "would add to current evidence that rehabilitation can be effective even in difficult and long-standing cases";{{ran|M1|p=831}} and if Gage could achieve such improvement without medical supervision, "what are the limits for those in formal rehabilitation programs?"{{hsp}}{{ran|M9}} As author Sam Kean put it, "If even Phineas Gage bounced back{{mdashb}}that's a powerful message of hope."{{hsp}}{{ran|K}}

===Exaggeration and distortion of mental changes===
<!--above section header is linked from [[Cognitive Neuropsychology]] -->

{{Quote box |salign=right|align=right|width=22em
|quote = A moral man, Phineas Gage<br />Tamping powder down holes for his wage<br />{{nbsp|7}}Blew his special-made probe<br />{{nbsp|7}}Through his left frontal lobe<br />Now he drinks, swears, and flies in a rage.
|author = Anonymous [[Limerick (poetry)|limerick]]{{ran|L1|p=168}}
}}

Macmillan's analysis of scientific and popular accounts of Gage found that they almost always distort and exaggerate his behavioral changes well beyond anything described by anyone who had direct contact with him,{{NoteTag|name=accounts_reliablesources}} concluding that the known facts are "inconsistent with the common view of Gage as a boastful, brawling, foul-mouthed, dishonest useless drifter, unable to hold down a job, who died penniless in an institution".{{hsp}}{{r|macmillan_encyc}} In the words of Barker, "As years passed, the case took on a life of its own, accruing novel additions to Gage's story without any factual basis".{{ran|B|p=678}} Even today (writes Zbigniew Kotowicz) "Most commentators still rely on hearsay and accept what others have said about Gage, namely, that after the accident he became a [[psychopath]]";{{ran|K2|p=125}} Grafman has written that "the details of [Gage's] social cognitive impairment have occasionally been inferred or even embellished to suit the enthusiasm of the story teller";{{ran|G|p=295}}
and Goldenberg calls Gage "a (nearly) blank sheet upon which authors can write stories which illustrate their theories and entertain the public".{{hsp}}{{r|goldenberg}}

For example, Harlow's statement that Gage "continued to work in various places; could not do much, changing often, and always finding something that did not suit him in every place he tried"{{hsp}}{{ran|H|p=15}} refers only to Gage's final months, after convulsions had set in.{{ran|M|p=107}}{{ran|M10|p=646}} But it has been misinterpreted{{r|work}} as meaning that Gage ''never'' held a regular job after his accident,{{r|hockenbury}}{{r|employment}}{{r|mann}} "was prone to quit in a capricious fit or be let go because of poor discipline",{{r|damasioA_descartes|p=8-9}} "never returned to a fully independent existence",{{r|damasioH_return|p=1102}} "spent the rest of his life living miserably off the charity of others and traveling around the country as a sideshow freak",{{r|mann}} and ("dependent on his family"{{hsp}}{{r|ebenezer}} or "in the custody of his parents"){{r|bower}} died "in careless dissipation".{{r|damasioA_neuropsychology}} In fact, after his initial post-recovery months spent traveling and exhibiting, Gage supported himself{{mdashb}}at a total of just two different jobs{{mdashb}}from early 1851 until just before his death in 1860.{{wbo}}{{ran|M10|p=654-55}}{{ran|D|p=77}}

Other behaviors ascribed, by various authors, to the post-accident Gage that are either unsupported by, or in contradiction to, the known facts include the following:
{{columns-list|colwidth=32em|
* mistreatment of wife and children (though Gage actually had neither);{{r|wife}}
* inappropriate sexual behavior, promiscuity, or impaired sexuality;{{r|sexuality}}
* lack of forethought, concern for the future, or capacity for embarrassment;{{r|forethought}}
* parading his self-misery, and vainglory in showing his wounds;{{r|forethought}}
* "gambling" himself into "emotional and reputational{{nbsp}}... bankruptcy";{{r|plante}}
* irresponsibility, untrustworthiness,{{r|irresponsibility}} aggressiveness, violence;{{r|aggressiveness}}
* vagrancy, begging,{{r|vagrancy}} drifting,{{r|drifting}} drinking;{{r|drinking}}
* lying,{{r|lying}} brawling,{{r|brawling}} bullying;{{r|bullying}}
* [[psychopathy]],{{r|psychopathy|plante}} inability to make ethical decisions;{{r|idiot}}
* "[loss of] all respect for social conventions";{{r|idiot}}
* acting like an "idiot"{{hsp}}{{r|idiot}} or a "lout";{{r|mann}}
* living as a "layabout"{{hsp}}{{r|ahlstrom}} or a "boorish mess";{{r|boorish}}
* "[alienating] almost everyone who had ever cared about him";{{r|pelham}}
* dying "due to a [[wikt:debauchery#Noun|debauch]]".{{r|northcarolina}}
}}
None of these behaviors are mentioned by anyone who had met Gage or even his family,{{NoteTag
|name=accounts_reliablesources
|Macmillan{{ran|M|p=116-19,ch13-4}}{{ran|M2|p=C}}{{ran|M6}} compares accounts of Gage to one another and against the known facts, as well as contrasting Gage's celebrity{{mdashb}}he is mentioned in 91 percent of a sample of introductory psychology textbooks published 2012{{ndash}}2014{{r|griggs|p=198}}{{mdashb}}with what was, until comparatively recently, the lack of any major study of him and the dearth of papers solely or mainly about him.{{wbo}}{{ran|M|p=1-2,11}}
{{paragraph break}}
Until 2008{{ran|M10|p=642-43}}{{ran|M1|p=830}} the available primary sources offering significant information on Gage, and for which there is any evidence at all (even merely the source's own claim) of contact with Gage or his family, were limited to Harlow (1848, 1849, 1868);{{wbo}}{{ran|H1}}{{ran|H2}}{{ran|H}} Bigelow (1850);{{ran|B1}} and Jackson (1849, 1870).{{r|jackson1849|jackson1870}} Macmillan notes that descriptions of Gage's behavior{{mdashb}}the source of the perennial interest in the case{{mdashb}}total just 300 words{{ran|M|p=90}} and emphasizes the primacy of Harlow's three publications as sources.{{wbo}}{{ran|M|p=94,333,375}} (Harlow's original case notes have not been located.{{ran|M|p=90}} A Warren Museum curator referred to the "stately elegance" of Harlow's writings on Gage.){{r|yakovlev}} However, all of these sources were difficult to obtain prior to 2000{{r|griggs|p=196}}{{mdashb}}for example, Macmillan was able to identify something more than 21 copies of Harlow's 1868 paper{{ran|H}} worldwide{{ran|M|p=371-72}}{{mdashb}}and Macmillan believes this has helped allow distorted descriptions of Gage to flourish.{{ran|M1|p=831}}

Macmillan&nbsp;& Lena{{ran|M10|p=643-46,648}} present previously unknown sources found since 2008.
<!--end efn>>-->}}
and as Kotowicz put it, "Harlow does not report a single act that Gage should have been ashamed of."{{hsp}}{{ran|K2|p=122-23}} Gage is "a great story for illustrating the need to go back to original sources", writes Macmillan,{{r|benderly}} most authors having been "content to summarize or paraphrase accounts that are already seriously in error".{{hsp}}{{ran|M|p=315}}

Nonetheless (write Daffner and Searl) "the telling of [Gage's] story has increased interest in understanding the enigmatic role that the frontal lobes play in behavior and personality",{{r|daffner}} and Ratiu has said that in teaching about the frontal lobes, an anecdote about Gage is like an "ace [up] your sleeve. It's just like whenever you talk about the French Revolution you talk about the [[Guillotine#Reign of Terror|guillotine]], because it's so cool."{{hsp}}{{ran|K}}
Benderly suggests that instructors use the Gage case to illustrate the importance of critical thinking.{{r|benderly}}

===Extent of brain damage===

[[File:Phineas Gage injury - animation (frontal lobe).gif|thumb|left|upright=0.75|alt=A diagram of Gage's skull|The left frontal lobe ''(red)'', with Ratiu et&nbsp;al.'s estimate of the tamping iron's path{{ran|R1}}]]

{{Quote box |salign=right|align=right|width=22em
|quote = It is regretted that an autopsy could not have been had, so that the {{shy|pre|cise condi|tion}} of the [[wikt:encephalon#Noun|{{shy|en|ceph|a|lon}}]] at the time of his death might have been known.
|author = [[J. M. Harlow]] (1868){{ran|H|page=342}}
}}

{{external media |float=right|width=22em |video1= [http://www.nejm.org/action/showMediaPlayer?doi=10.1056%2FNEJMicm031024&aid=NEJMicm031024_attach_1&area= {{shy|Video re|con|struc|tion of tamp|ing iron pass|ing through Gage's skull] (Ratiu et&nbsp;al.){{ran|R1}} {{registration required}} }}
}}

{{shy|Debate about whether the trauma and sub|se|quent infect|ion had damaged Gage's left ''and'' right [[frontal lobes]], or only the left, began almost immedi|ate|ly after his accident.{{wbo}}{{NoteTag
|{{ran|M|p=3,71}} Early attempts to estimate the extent of damage include those by: Harlow (1848);{{ran|H1|p=389}} [[Edward Elisha Phelps]] (1849);{{r|jackson1849}} Bigelow (1850);{{ran|B1|p=21-22}} Harlow (1868);{{ran|H|p=17-19}} Hammond (1871);{{r|hammond}} Dupuy (1873, 1877);{{r|dupuy1873}}{{r|dupuy1877}} Ferrier (1877{{ndash}}79);{{r|ferrier1877_9}}{{r|ferrier1878}} Bramwell (1888);{{r|bramwell}} Cobb (1840, 1843);{{wbo}}{{r|cobb1940|p=1349}}{{wbo}}{{r|cobb1943|p=54-56}} Tyler&nbsp;& Tyler (1982).{{ran|T2}} See [[#CITEREFM|Macmillan (2000)]], Ch.{{nbsp}}5.
<!--end efn>>-->}} The 1994 con|clu|sion of [[Hanna Damasio]] et&nbsp;al., that the tamping iron did physical damage to both lobes, was drawn not from Gage's skull but from a cadaver skull dig|i|tal|ly deformed to match the dimen|sions of Gage's{{wbo}}{{ran|M1|p=829-30}}{{wbo}}{{r|damasioH_return|p=1103-4}}{{mdashb}}and made ''a{{nbsp}}priori'' assumptions about the location of Gage's internal injuries and the exit wound which in some cases contradict Harlow's observations.{{r|hayward}}{{ran|M|p=77-82}} Using [[Computed tomography|CT scans]] of Gage's actual skull, Ratiu et&nbsp;al.{{ran|R|p=638}} and Van Horn et&nbsp;al.{{ran|V|p=4-5,22}} both rejected that conclusion, agreeing with Harlow's belief{{mdashb}}based on probing Gage's wounds with his fingers{{mdashb}}that only the left frontal lobe had been damaged.{{wbo}}{{r|fingers}}{{NoteTag
|In any event, any such analysis can estimate only the initial, direct damage done by the passage of the tamping iron itself; it cannot account for additional damage from concussion, from bone fragments pushed along by the iron after it broke through the base of the cranium, or from the extensive bleeding and severe infection.
Further uncertainty stems from individual variations in the position of the brain within the skull, and in the points at which various brain functions are localized.{{wbo}}{{ran|M|p=84-86}}
<!--end efn>>-->}}
<!--end shy>>-->}}

[[File:Simulated Connectivity Damage of Phineas Gage 4 vanHorn PathwaysDamaged.jpg|thumb|right|upright=1.2|alt=A diagram of Gage's skull|False-color representations of [[white matter|cerebral fiber]] pathways affected, per Van Horn et&nbsp;al.{{ran|V|p=3}} ]]

In addition, Ratiu et&nbsp;al. noted that the hole in the base of the cranium (created as the tamping iron passed through the [[sphenoidal sinus]] into the brain) has a diameter about half that of the iron itself; combining this with the hairline fracture beginning behind the exit region and running down the front of the skull, they concluded that the skull "hinged" open as the iron entered from below, then was pulled closed by the resilience of soft tissues once the iron had exited through the top of the head.{{wbo}}{{ran|R|p=640}}{{ran|M1|p=830}}

Van Horn et&nbsp;al. concluded that damage to Gage's [[white matter]] (of which they made detailed estimates) was as or more significant to Gage's mental changes than [[cerebral cortex]] (gray matter) damage.{{ran|V|p=abstr}} Thiebaut de Schotten et&nbsp;al. estimated white-matter damage in Gage and two other case studies ("[[Broca's area#Louis Victor Leborgne (Tan)|Tan]]" and "[[H.M. (patient)|H.M.]]"), concluding that these patients "suggest that social behavior, language, and memory depend on the coordinated activity of different [brain] regions rather than single areas in the frontal or temporal lobes."{{ran|T1|p=12}}

==<span id="Factors favoring"></span>Factors favoring Gage's survival==

[[File:Recovery from the passage of an iron bar through the head p2 rotateRt0pt47 crop.jpg|thumb|left|upright=1.0 |link=File:Recovery_from_the_passage_of_an_iron_bar_through_the_head.djvu|alt=The cover of a journal article titled "Recovery from the passage of an iron bar through the head".|"I have the pleasure of being able to present to you [a case] without parallel in the annals of surgery."{{hsp}}{{ran|H|p=3}} Harlow's 1868 presentation to the [[Massachusetts Medical Society|{{shy|Mas|sa|chu|setts}} Medical Society]]{{ran|H|p=tp}} of Gage's skull, tamping iron, and post-accident history.]]

Harlow saw Gage's survival as demonstrating "the wonderful resources of the system in enduring the shock and in overcoming the effects of so frightful a lesion, and as a beautiful display of the recuperative powers of nature", and listed what he saw as the circumstances favoring it:
{{blockquote|
1st. The subject was the man for the case. His physique, will, and capacity of endurance, could scarcely be excelled.{{ran|H|p=18}}
}}

For Harlow's description of the pre-accident Gage, see [[#Background|§ Background]], above.

{{blockquote|
2d. The shape of the missile{{mdashb}}being pointed, round and comparatively smooth, not leaving behind it prolonged concussion or compression.{{ran|H|p=18}}
}}

Despite its very large diameter and mass (compared to a weapon-fired projectile) the tamping iron's relatively low velocity drastically reduced the energy available to compressive and concussive "shock waves".{{wbo}}{{ran|M|p=56,68n3}}{{wbo}}{{r|ordia|mitchell}}

Harlow continued:
{{blockquote|
3d. The point of entrance{{nbsp}}... [The tamping iron] did little injury until it reached the floor of the cranium, when, at the same time that it did irreparable damage, it [created the] opening in the base of the skull, for drainage, [without which] recovery would have been impossible.{{NoteTag|
{{ran|H|p=18}} Harlow's full text, "The point of entrance outside of the [[superior maxillary]]{{mdashb}}the [tamping iron] did little injury&nbsp;..." refers to the first point at which the tamping iron contacted bone; elsewhere he describes the initial penetration (i.e. of the tissue of the face) as "immediately anterior and external to the angle of the inferior maxillary bone",{{ran|H|p=16}} consistent with the analyses of Macmillan; Ratiu et al.; and Van Horn et al.{{wbo}}{{ran|B1|p=13-14}}{{ran|H|p=5}}{{ran|M|p=73-74}}{{r|ratiu_vanhorn}}
<!--end efn-->}}
}}

Barker writes that "[Head injuries] from falls, horse kicks, and gunfire, were well known in pre{{ndash}}Civil War America [and] every contemporary course of lectures on surgery described the diagnosis and treatment" of such injuries. But to Gage's benefit, surgeon [[Joseph Pancoast]] had performed "his most celebrated operation for head injury before Harlow's medical class, {{bracket|[[trepanning]]}} to drain the pus, resulting in temporary recovery. Unfortunately, symptoms recurred and the patient died. At autopsy, reaccumulated pus was found: [[granulation tissue]] had blocked the opening in the [[Dura mater|dura]]." By keeping the exit wound open, and elevating Gage's head to encourage drainage from the cranium into the sinuses (through the hole made by the tamping iron), Harlow "had not repeated Professor Pancoast's mistake".{{wbo}}{{ran|B|p=675}}{{ran|M|p=58}}{{r|pancoast}}

{{Quote box |salign=right|align=right|width=22.6em
|quote = {{shy|No attempt will be made by me to cite analo|gous cases, as after ran|sack|ing the lit|er|a|ture of sur|gery in quest of such, I learn that all, or nearly all,<!--<<Pubs Mass Med Soc, and pamphlet, disagree on whether there's a comma here -- see https://en.wikisource.org/wiki/Page%3ARecovery_from_the_passage_of_an_iron_bar_through_the_head.djvu/18 -- including comma since it makes sense--> soon came to a fatal result.}}
|author = [[J. M. Harlow]] (1868){{ran|H|p=344}}
}}

Finally,
{{blockquote|
4th. The portion of the brain traversed was, for several reasons, the best fitted of any part of the cerebral substance to sustain the injury.{{ran|H|p=18}}
}}

Precisely what Harlow's "several reasons" were is unclear, but he was likely referring, at least in part, to the understanding (slowly developing since ancient times) that injuries to the front of the brain are less dangerous than are those to the rear, because the latter frequently interrupt vital functions such as breathing and circulation.{{ran|M|p=126,142}} For example, surgeon [[James Earle]] wrote in 1790 that "a great part of the [[cerebrum]] may be taken away without destroying the animal, or even depriving it of its faculties, whereas the [[cerebellum]] will scarcely admit the smallest injury, without being followed by mortal symptoms."{{hsp}}{{wbo}}{{ran|M|p=128}}{{r|pott}}

[[File:ScientificAmerican 1868Jul1 v19n1 AWonderfulSkull.png|thumb|left|upright=1.35|alt=A newspaper article|Harlow's 1868 paper on Gage was widely reported.{{ran|M|p=112-14}} This item appeared in ''Scientific American'' for July 1868.]]

Ratiu et&nbsp;al. and Van Horn et&nbsp;al. both concluded that the tamping iron passed left of the [[superior sagittal sinus]] and left it intact, both because Harlow does not mention loss of [[cerebrospinal fluid]] through the nose, and because otherwise Gage would almost certainly have suffered fatal blood loss or [[air embolism]].{{wbo}}{{ran|R|p=640}}{{ran|V|p=17}}
Harlow's moderate (in the context of medical practice of the time) use of [[emetic]]s, [[purgative]]s, and (in one instance) [[bloodletting|bleeding]]{{ran|M|p=59-60}} would have "produced dehydration with reduction of intracranial pressure [which] may have favorably influenced the outcome of the case", according to Steegmann.{{r|steegmann|p=956}}

As to his own role in Gage's survival, Harlow merely averred, "I can only say&nbsp;... with good old [[Ambroise Paré]], I [[wikt:dress#English: treat wound|dressed]] him, God healed him",{{ran|H|p=20}} but Macmillan calls this self-assessment far too modest.{{refn| [[#CITEREFM|Macmillan (2000)]], p. 12, ch. 4, pp. 355{{ndash}}59; [[#CITEREFM1|Macmillan (2008)]], pp. 28{{ndash}}29; [[#CITEREFM7|Macmillan (2001)]], pp. 151{{ndash}}53. }} Noting that Harlow had been a "relatively inexperienced local physician&nbsp;... graduated four and a half years earlier",{{ran|M|p=12}} Macmillan's discussion of Harlow's "skillful and imaginative adaptation [of] conservative and progressive elements from the available therapies to the particular needs posed by Gage's injuries" emphasizes that Harlow "did not apply rigidly what he had learned", for example forgoing an exhaustive search for bone fragments (which risked hemorrhage and further brain injury) and applying [[Silver nitrate|caustic]] to the "fungi" instead of excising them (which risked hemorrhage) or forcing them into the wound (which risked compressing the brain).{{ran|M|p=58-62}}

==Early medical attitudes==

===Skepticism===
{{Quote box |salign=right|align=right|width=24em
|quote = {{shy|The very small amount of atten|tion that has been given to [this] case can only be ex|plained by the fact that it far tran|scends any case of recov|ery from inju|ry of the head that can be found in the rec|ords of sur|gery. It was too mon|strous for belief&nbsp;...}}
|author = [[J. B. S. Jackson]] (1870){{r|jackson1870|p=149}}
}}

[[File:JohnMartynHarlow death recalls PhineasGage case BostonHerald May 20 1907 p12.png|right|upright=0.80|thumb|alt=A newspaper article on the death of Harlow|''[[Boston Herald]]'', 1907]]

{{shy|Barker notes that Harlow's orig|i|nal 1848 report of Gage's sur|viv|al and recov|ery "was widely dis|be|lieved, for obvious reasons"{{hsp}}{{ran|B|p=676}} and Harlow, recall|ing this early skep|ti|cism in his 1868 ret|ro|spec|tive, invoked the biblical  story of [[Doubting Thomas]]:{{ran|L1|p=178}} }}
{{blockquote|{{shy|The case occurred nearly twenty years ago, in an obscure country town&nbsp;..., was attended and reported by an obscure country phy|si|cian, and was received by the Met|ro|pol|i|tan Doctors with several grains of caution, insomuch that many utterly refused to believe that the man had risen, until they had thrust their fingers into the hole [in] his head, and even then they required of the Country Doctor attested state|ments, from clergy|men and lawyers, before they could or would believe{{mdashb}}many eminent surgeons regarding such an occur|rence as a phys|i|o|log|i|cal impos|si|bil|i|ty, the appear|ances pre|sented by the subject being var|i|ous|ly explained away.}}
}}

"A distinguished Professor of Surgery in a distant city", Harlow continued, had even dismissed Gage as a "[[Yankee]] invention".{{ran|H|p=3,18}}

According to the ''[[Boston Medical and Surgical Journal]]'' (1869) it was the 1850 report on Gage by Bigelow{{mdashb}}Harvard's Professor of Surgery and "a majestic and {{shy|author|i|ta|tive}} figure on the medical scene of those times"{{hsp}}{{r|yakovlev}}{{mdashb}}that "finally succeeded in forcing [the case's] authenticity upon the credence of the {{shy|pro|fes|sion&nbsp;...}} as could hardly have been done by any one in whose sagacity and surgical knowledge his ''[[wikt:confrère#Noun|confrères]]'' had any less confidence".{{r|anonymous_bmsj1869_1}} Noting that, "The leading feature of this case is its {{shy|improb|a|bil|i|ty&nbsp;...}} This is the sort of accident that happens in the pantomime at the theater, not elsewhere", Bigelow emphasized that though "at first wholly skeptical, I have been personally convinced".{{NoteTag
|In addition to the "attested statements" mentioned by Harlow (which Harlow had gathered at Bigelow's request) and his own examination of Gage, Bigelow pointed out that the accident had occurred "in open day" with many witnesses, and that "in a thickly populated country neighbourhood, to which all the facts were matter of daily discussion at the time of their occurrence, there is no difference of belief, nor has there been at any time doubt that the iron was actually driven through the brain. A considerable number of medical gentlemen also visited the case at various times to satisfy their incredulity."{{hsp}}{{wbo}}{{ran|B1|p=13,19-20}}{{ran|M|p=42}}
<!--end efn>>-->}}

Nonetheless (Bigelow wrote just before Harlow's 1868 presentation of Gage's skull) though "the nature of [Gage's] injury and its ''reality'' are now ''beyond doubt''&nbsp;... I{{nbsp}}have received a letter within a month [purporting] to prove that&nbsp;... the accident ''could not have happened''."{{hsp}}{{ran|B2}}

===Standard for other brain injuries===
[[File:Phineas Gage Countway Library.jpg|alt=Gage's disassembled skull on display at the Warren Anatomical Museum (Harvard Medical School).|left|thumb|224x224px|"[Few objects] have {{shy|at|tract|ed more vis|i|tors}} and spread farther the fame of the [[Warren Anatomical Museum|Museum]]"{{wbo}}{{r|yakovlev}}
than its "most {{shy|val|u|a|ble}} specimen"{{mdashb}}Gage's skull.{{wbo}}{{r|jackson1870|p=v}}]]
As the reality of Gage's accident and survival gained credence, it became "the standard against which other injuries to the brain were judged", and it has retained that status despite competition from a growing list of other unlikely-sounding brain-injury accidents, including encounters with axes, bolts, low bridges, exploding firearms, a revolver shot to the nose, further tamping irons, and [[Eucalyptus#Falling branches|falling Eucalyptus branches]].{{ran|M|p=62-67}}
For example, after a miner survived traversal of his skull by a gas pipe {{convert|5/8|in|cm}} in diameter (extracted "not without considerable difficulty and force, owing to a bend in the portion of the rod in his skull"), his physician invoked Gage as the "only case comparable with this, in the amount of brain injury, that I have seen reported".{{NoteTag|
{{ran|M|p=66}}{{r|anonymous_bmsj1868 }} Immediately after Harlow's presentation unveiling Gage's skull and iron, Bigelow ("in one of those ''coups dramatiques'' which were now and then incidents of his surgical communications [and] without giving notice that he intended to do so"){{r|memoir_hjb|p=123}} actually produced this patient, Joel Lenn, together with "the gas pipe which had pierced his head from the right forehead to left [[occiput]], and the hat he had been wearing (with entrance and exit holes)&nbsp;... This ''coup de théâtre'' must have been a painful coda for Harlow, eclipsing the pinnacle of his medical career."{{hsp}}{{ran|B|p=679}}
Months after Lenn's accident his surgeon reported, "He seems to be perfectly rational, and will reply correctly in ''monosyllables'' to questions, but is entirely unable to ''connect words''. He succeeds best, when excited, in swearing in French."{{hsp}}{{r|jewett}}
<!--end enf>>-->}}

Often these comparisons carried hints of humor, competitiveness, or both.{{ran|M|p=66}} The ''Boston Medical and Surgical Journal'', for example, alluded to Gage's astonishing survival by referring to him as "the patient whose cerebral organism had been comparatively so little disturbed by its abrupt and intrusive visitor";{{r|anonymous_bmsj1869_1}} and a Kentucky doctor, reporting a patient's survival of a gunshot through the nose, bragged, "If you [[wikt:Yankee#English: south north|Yankees]] can send a tamping bar through a fellow's brain and not kill him, I guess there are not many can shoot a bullet between a man's mouth and his brains, stopping just short of the [[medulla oblongata]], and not touch either."{{r|sutton}}
Similarly, when a lumbermill foreman returned to work soon after a saw cut {{convert|3|in|cm|spell=in|sigfig=1}} into his skull from just between the eyes to behind the top of his head, his surgeon (who had removed from this wound "thirty-two pieces of bone, together with considerable sawdust") termed the case "second to none reported, save the famous tamping-iron case of Dr. Harlow", though apologizing that "I cannot well gratify the desire of my professional brethren to possess [the patient's] skull, until he has no further use for it himself."{{r|folsom}}

As these and other remarkable brain-injury survivals accumulated, the ''Boston Medical and Surgical Journal'' pretended to wonder whether the brain has any function at all: "Since the antics of iron bars, gas pipes, and the like skepticism is discomfitted, and dares not utter itself. Brains do not seem to be of much account now-a-days." The ''Transactions of the Vermont Medical Society'' was similarly facetious: {{"'}}The times have been,'<!-- /The times have been/ is given in the source, though Shakespeare's line actually reads, /The time has been/--> says Macbeth {{bracket|[[s:The Tragedy of Macbeth/Act III#Blood hath been shed ere now|Act&nbsp;III]]}}, 'that when the brains were out the man would die. But now they rise again.' Quite possibly we shall soon hear that some German professor is [[wikt:exsect|exsecting]] it."{{hsp}}{{wbo}}{{ran|L1|p=183}}{{r|anonymous_bmsj1869_2}}{{r|smithW|p=53-54}}

==Theoretical misuse==

{{Quote box |salign=right|align=right|width=24.7em
|quote = The Gage who appears in contemporary psychology textbooks is simply a compound creature{{nbsp}}... a stunning example of the ideological uses of case histories and their mythological reconstruction.
|author = Rhodri Hayward{{r|hayward}}
}}

Though Gage is considered the "[[index case]] for personality change due to frontal lobe damage",{{hsp}}{{wbo}}{{ran|B|p=672}}{{r|stuss}}{{wbo}}{{r|hockenbury}}{{wbo}}{{ran|F1}}{{wbo}}{{ran|M|p=1}} the uncertain extent of his brain damage{{wbo}}{{ran|F1}}{{r|cobb1940|p=1349}}{{ran|M|p=11,ch5}} and the limited understanding of his behavioral changes{{NoteTag|name=accounts_reliablesources}} render him "of more historical than neurologic {{sic}}<!--<<"neurologic" is in the original, and apparently is correct -- see https://www.aan.com/globals/axon/assets/3078.pdf p.11--> interest".{{r|cobb1940|p=1348}} Thus, Macmillan writes, "Phineas' story is [primarily] worth remembering because it illustrates how easily a small stock of facts becomes transformed into popular and scientific myth",{{refn| [[#CITEREFM1|Macmillan (2008)]], p. 831; [[#CITEREFM|Macmillan (2000)]], chs. 5{{ndash}}6,9{{ndash}}14; [[#CITEREFM5|Macmillan (1996)]], pp. 251{{ndash}}59. }} the paucity of evidence having allowed "the fitting of almost any theory [desired] to the small number of facts we have".{{ran|M|p=290}} A similar concern was expressed as early as 1877, when British neurologist [[David Ferrier]] (writing to Harvard's [[Henry Pickering Bowditch]] in an attempt "to have this case definitely settled") complained that, "In investigating reports on diseases and injuries of the brain, I am constantly being amazed at the inexactitude and distortion to which they are subject by men who have some pet theory to support. The facts suffer so frightfully&nbsp;..."{{hsp}}{{wbo}}{{ran|M|p=1,75,197-79,464-65}}{{wbo}}{{r|ferrier1877_9}}
More recently, neurologist [[Oliver Sacks]] refers to the "interpretations and misinterpretations [of Gage] from 1848<!--<<silently corrected from "1948" in the source, clearly a slip of the pen--> to the present",{{r|sacks}}
and Jarrett discusses the use of Gage to promote "the myth, found in hundreds of psychology and neuroscience textbooks, plays, films, poems, and YouTube skits[:] Personality is located in the frontal lobes{{nbsp}}... and once those are damaged, a person is changed forever."{{hsp}}{{r|jarrett2}}

===Cerebral localization===
[[File:PhrenologyPix, upper front with inset GageRegions.jpg|thumb|right|upright=1.3|link=File:PhrenologyPix.jpg|alt=A diagram of regions of the brain used in phrenology|[[Phrenology|Phrenologists]] contended that destruction of the mental "organs" of Veneration and Benevolence caused Gage's behavioral changes. Harlow may have believed that the Organ of Comparison was damaged as well. ]]

In the 19th-century debate over whether the various mental functions are or are not localized in specific regions of the brain {{Crossreference|(see [[Cerebral localization]])}}, both sides managed to enlist Gage in support of their theories.{{ran|B|p=678}}{{ran|M|p=ch9}} For example, after Eugene Dupuy wrote that Gage proved that the brain is not localized (characterizing him as a "striking case of destruction of the so-called [[Broca's area|speech centre]] without consequent [[aphasia]]") Ferrier replied by using Gage (along with the woodcuts of his skull and tamping iron from Harlow's 1868 paper) to support his thesis that the brain ''is'' localized.{{wbo}}{{r|dupuy1877}}{{r|ferrier1878}}{{ran|M|p=188}}{{wbo}}{{ran|M5|p=198,253}}

===Phrenology===<!--this section name referenced by links elsewhere in the article-->
[[File:PhineasGage_CavendishMemorialPlaque.jpg|link=File:PhineasGage_CavendishMemorialPlaque2.jpg|thumb|upright=1.3|alt=Refer to caption|Memorial plaque, [[Cavendish (CDP), Vermont|Cavendish, Vermont]] ]]

Throughout the 19th century, adherents of [[phrenology]] contended that Gage's mental changes (his profanity, for example) stemmed from destruction of his mental "organ of [[wikt:benevolence#Noun|Benevolence]]"{{mdashb}}as phrenologists saw it, the part of the brain responsible for "goodness, benevolence, the gentle character&nbsp;... [and] to dispose man to conduct himself in a manner conformed to the maintenance of social order"{{mdashb}}and/or the adjacent "organ of [[wikt:veneration#Noun|Veneration]]"{{mdashb}}related to religion and God, and respect for peers and those in authority.{{wbo}}{{ran|M|p=150-51,171n10}}{{wbo}}{{r|gall_sizer}}{{wbo}}{{r|northstar}}{{wbo}}{{r|amer_phren}} (Phrenology held that the organs of the "grosser and more animal passions are near the base of the brain; literally the lowest and nearest the animal man [while] highest and farthest from the sensual are the moral and religions feelings, as if to be nearest heaven". Thus Veneration and Benevolence are at the apex of the skull{{mdashb}}the region of exit of Gage's tamping iron.){{r|apex}}

Harlow wrote that Gage, during his convalescence, did not "estimate size or money accurately[,] would not take $1000 for a few pebbles"{{ran|H1|p=392}} and was not particular about prices when visiting a local store;{{ran|H|p=337}} by these examples Harlow may have been implying damage to phrenology's "Organ of Comparison".{{NoteTag|
{{ran|B|p=675-76}}{{ran|H|p=168-69}} However, this is somewhat contradicted by Harlow's statement that Gage paid "with his habitual accuracy" during the store visit.{{wbo}}{{ran|H|p=337}}{{ran|M|p=169}}
<!--end efn>>-->}}

===Psychosurgery and lobotomy===

It is frequently asserted that what happened to Gage played a role in the later development of various forms of [[psychosurgery]]{{mdashb}}particularly [[lobotomy]]{{r|lobotomy}}{{mdashb}}or even that Gage's accident constituted "the first lobotomy".{{r|vanderkloot}}{{r|rotarian}} Aside from the question of why the unpleasant changes usually (if hyperbolically) attributed to Gage would inspire surgical imitation,{{r|turner}} there is no such link, according to Macmillan:

{{blockquote|There is simply no evidence that any of these operations were deliberately designed to produce the kinds of changes in Gage that were caused by his accident, nor that knowledge of Gage's fate formed part of the rationale for them{{ran|M2|p=F}}{{zwj}}... [W]hat his case did show came solely from his surviving his accident: major operations [such as for tumors] could be performed on the brain without the outcome necessarily being fatal.{{ran|M|p=250}}
}}

===Somatic marker hypothesis===

[[Antonio Damasio]], in support of his ''[[somatic marker hypothesis]]'' (relating decision-making to emotions and their biological underpinnings), draws parallels between behaviors he ascribes to Gage and those of modern patients with damage to the [[orbitofrontal cortex]] and [[amygdala]].{{r|damasioA_descartes|p=ch3|damasioA_somatic}} But Damasio's depiction of Gage{{r|damasioA_descartes|p=ch1}} has been severely criticized, for example by Kotowicz:

{{blockquote|Damasio is the principal perpetrator of the myth of Gage the {{shy|psycho|path{{nbsp}}... Damasio changes [Harlow's] nar|ra|tive, omits facts, and adds freely{{nbsp}}... His account of Gage's last months [is] a gro|tesque fab|ri|ca|tion [insin|u|at|ing] that Gage was some riff-raff who in his final days headed for Cal|i|for|nia to drink and brawl himself to death{{nbsp}}... It seems that the growing com|mit|ment to the frontal lobe doctrine of emotions brought Gage to the lime|light and shapes how he is described.{{ran|K2|p=125,130n6}}}} }}

As Kihlstrom put it, "[M]any modern commentators exaggerate the extent of Gage's personality change, perhaps engaging in a kind of retrospective reconstruction based on what we now know, or think we do, about the role of the frontal cortex in self-regulation."{{ran|K1}}
Macmillan{{wbo}}{{ran|M|p=116-19,326,331}} gives detailed criticism of Antonio Damasio's various presentations of Gage (some of which are joint work with Hannah Damasio and others).

==Portraits==

[[File:Phineas Gage GageMillerPhoto2010-02-17 TampingIron EnhancedCropped.jpg|thumb|left|upright=1.2|alt=Refer to caption|Inscription on iron as seen in portrait detail: ''...&nbsp;[Phine]has P. Gage at Cavendish, Vermont, Sept. 14, 1848. {{nobr|He fully{{nbsp}}...}}'']]
[[File:Phineas Gage GageMillerPhoto2010-02-17 Unretouched Color Cropped.jpg|thumb|right|upright=0.85|alt=Refer to caption|The second portrait of Gage identified (2010){{NoteTag|name=dags}}]]

Two [[daguerreotype]] portraits of Gage, identi{{shy}}fied in 2009 and 2010,{{NoteTag
|name=dags
|The 2009-identified image was, at the time, in the collection of Jack and Beverly Wilgus,{{wbo}}{{ran|T}}{{ran|W2}}{{wbo}}{{ran|W}}{{wbo}}{{ran|W1}} but in 2016 was donated to the Warren Anatomical Museum.{{r|silvestro}} Like almost all {{shy|da|guerre|o|types}} it shows its subject laterally (left{{ndash}}right) reversed, making it appear as if Gage's right eye is injured. However, all Gage's injuries, including to his eye, were on the left; therefore in presenting the image in this article a second, compensating reversal has been applied so as to show Gage as he appeared in life.{{wbo}}{{ran|L}}{{ran|W}}{{ran|W1}}
{{paragraph break}}
The 2010-identified image is in the possession of Tara Gage Miller of Texas; an identical image belongs to Phyllis Gage Hartley of New Jersey.{{ran|L}} Unlike the Wilgus portrait, which is an original {{shy|da|guerre|o|type}}, the Miller and Hartley images are 19th-century photographic reproductions of a common original which remains undiscovered, itself a {{shy|da|guerre|o|type}} or other laterally reversing [[History of photography|early-process photograph]];{{ran|W1}} here again a compensating reversal has been applied.{{ran|L}}
<!--end efn>>-->}} are the only {{shy|like|nes|ses}}{{wbo}}{{ran|W|p=343}}{{ran|T}}{{ran|W1|p=8}} of him known other than a plaster head cast taken for Bigelow in late 1849 (and now in the Warren Museum along with Gage's skull and tamping iron).{{NoteTag
|name=mask
|{{ran|B1|p=22n}}{{r|jackson1870|p=149}}{{ran|M|p=ii,42}} The head cast, taken from life, is often mistakenly referred to as a [[death mask]].{{ran|M2|p=G}}
}}
The first portrait shows a "disfigured yet still-handsome" Gage{{ran|T}} with left eye closed and scars clearly visible, "well dressed and confident, even proud"{{hsp}}{{ran|W|p=343}} and holding his iron, on which portions of its inscription can be made out.{{ran|W2}} (For decades the portrait's owners had believed that it depicted an injured whaler with his [[harpoon]].){{ran|W2}}
The second portrait, copies of which are in the possession of two branches of the Gage family, shows Gage in a somewhat different pose, wearing the same [[waistcoat]] and possibly the same jacket, but with a different shirt and tie.{{ran|W3}}{{ran|L}}

Authenticity of the portraits was confirmed by overlaying the inscription on the tamping iron, as seen in the portraits, against that on the actual tamping iron, and matching the subject's injuries to those preserved in the head cast.{{ran|W|p=342-43}}{{ran|L}} However, about when, where, and by whom the portraits were taken nothing is known, except that they were created no earlier than January 1850 (when the inscription was added to the tamping iron),{{ran|M10|p=644}} on different occasions, and are likely by different photographers.{{ran|W1|p=8}}

The portraits support other evidence that Gage's most serious mental changes were temporary {{see above|{{section link||Social recovery}}}}.{{ran|M9}}{{r|smithS_carey}} "That [Gage] was any form of vagrant following his injury is belied by these remarkable images", wrote Van Horn et&nbsp;al.{{ran|V|p=13}} "Although just one picture," Kean commented in reference to the first image discovered, "it exploded the common image of Gage as a dirty, disheveled misfit. This Phineas was proud, well-dressed, and disarmingly handsome."{{hsp}}{{ran|K}}

==See also==

{{columns-list|colwidth=40em|
* [[Anatoli Bugorski]]{{snd}}scientist whose head was struck by a particle-accelerator [[proton beam]]
* [[Eadweard Muybridge]]{{snd}}another early case of head injury leading to mental changes
* [[Alexis St. Martin]]{{snd}}man whose abdominal [[fistula]] allowed pioneering studies of digestion
* [[Henry Molaison]]{{snd}}patient "H.M.", who developed severe [[anterograde amnesia]] after surgery for epilepsy
* [[Lev Zasetsky]]{{snd}}soldier who developed [[agnosia]] after a bullet pierced his [[Parietal lobe|parieto]]-[[Occipital lobe|occipital]] area
* [[Ahad Israfil]]{{snd}}known for his recovery from a gunshot injury that destroyed most of his right cerebral hemisphere
}}
{{columns-list|colwidth=20em|
* [[Cognitive neuropsychology]]
* [[Cognitive rehabilitation therapy]]
* [[Neuroplasticity]]
* [[Neurorehabilitation]]
* [[Occupational therapy]]
* [[Rehabilitation (neuropsychology)]]
}}
{{clear<!-- {clear} ensures images don't compromise horizontal space available to Notes -->}}

==Notes==
{{NoteFoot|30em}}

==References==
'''For general readers'''
{{Refbegin|30em}}<!-- In the following, the occasional  |ref=none  is to silence "Harv error" seen by editors with certain scripts installed -->

{{rma| tag=K |reference= {{cite news
|title=Phineas Gage, Neuroscience's Most Famous Patient |work=Slate |date=May 6, 2014 |last=Kean |first=Sam
|url=http://www.slate.com/articles/health_and_science/science/2014/05/phineas_gage_neuroscience_case_true_story_of_famous_frontal_lobe_patient.html
|ref=none
}} Reprinted in {{cite book|editor-link=Rebecca Skloot|editor-last=Skloot|editor-first=Rebecca|year=2015|title=The Best American Science and Nature Writing 2015|publisher=Houghton Mifflin Harcourt|pages=143{{ndash}}48
|ref=none
}} }}

{{rma| tag=M |reference= {{cite book
|last=Macmillan |first=Malcolm B. |year=2000
|title=An Odd Kind of Fame: Stories of Phineas Gage |publisher=[[MIT Press]]
|url=https://books.google.com/books?id=Qx4fMsTqGFYC
|id= (hbk, 2000) (pbk, 2002)
|isbn=978-0-262-13363-0 |ref=none}} <!--limited preview--><br />{{bullet}}''See also'' [http://www.uakron.edu/gage/book.dot "''An Odd Kind of Fame'' §&nbsp;Corrections"].
}}

{{rma| tag=M1 |reference= {{cite journal |author-mask=2
|last=Macmillan |first=Malcolm B. |date=September 2008 |url=http://thepsychologist.bps.org.uk/volume-21/edition-9/phineas-gage-unravelling-myth
|title=Phineas Gage – Unravelling the myth |journal=The Psychologist |volume=21 |number=9
|pages=828{{ndash}}31.<!--Chk all cites for possible problem re pg #s in online vs print versions-->
|ref=none
}} }}

{{rma| tag=M2 |reference= {{cite web |author-mask=2
|last=Macmillan |first=Malcolm B. |year=2012<!--2012 was latest update to site-->
|url=http://www.uakron.edu/gage/index.dot
|title=The Phineas Gage Information Page |publisher=The University of Akron |access-date=2016-05-16 |ref=none}} Includes:
{{ordered list|list-style-type=none
|A. {{cite web |url=http://www.uakron.edu/gage/sites-and-plaque.dot |title=Phineas Gage Sites in Cavendish}}
|B. {{cite web |url=http://www.uakron.edu/gage/questions.dot |title=Phineas Gage: Unanswered questions}}
|C. {{cite web |url=http://www.uakron.edu/gage/story.dot |title=Phineas Gage's Story}}
|D. {{cite web |url=http://www.uakron.edu/gage/book.dot |title=''An Odd Kind of Fame''}}
|E. {{cite web |url=http://www.uakron.edu/gage/adaptation.dot |title=Phineas Gage: Psychosocial Adaptation}}
|F. {{cite web |url=http://www.uakron.edu/gage/lobotomy.dot |title=Phineas Gage and Frontal Lobotomies}}
|G. {{cite web |url=http://www.uakron.edu/gage/reviews.dot |title=Reviews}}
}} }}

{{rma| tag=M3 |reference= {{cite interview
|interviewer= Jon Hamilton |title=Why Brain Scientists are Still Obsessed with the Curious Case of Phineas Gage
|url=https://www.npr.org/sections/health-shots/2017/05/21/528966102/why-brain-scientists-are-still-obsessed-with-the-curious-case-of-phineas-gage
|format=mp3 |work=Health Shots |publisher=National Public Radio |date=May 21, 2017
|last=Macmillan |first=Malcolm |last2=Van Horn |first2=Jack |last3=Ropper |first3=Allan
|ref=none
}} }}

{{rma| tag=M4 |reference= {{cite interview|author-mask=2
|last1=Macmillan |first1=Malcolm B. |date=March 6, 2011 |last2=Aggleton |first2=John
|interviewer=Claudia Hammond |interviewer2=Dave Lee |type=Audio interview |work=Health Check |publisher=BBC World Service
|title=Phineas Gage: The man with a hole in his head |url=https://www.bbc.co.uk/news/health-12649555
|ref=none
}} [http://www.bbc.co.uk/programmes/b00bcccq Originally broadcast December 7, 2008]. }}

{{rma| tag=T |reference= {{cite journal |last=Twomey |first=S. |date=January 2010 |volume=40 |issue=10 |journal=[[Smithsonian Magazine|Smithsonian]] |url=http://www.smithsonianmag.com/history-archaeology/78437017.html |title=Finding Phineas |pages=8{{ndash}}10 |ref=none |access-date=2009-12-24  |archive-date=2010-02-09  |archive-url=https://web.archive.org/web/20100209065825/http://www.smithsonianmag.com/history-archaeology/78437017.html |url-status=dead }} }}

{{Refend}}

'''For younger readers'''
{{Refbegin}}

{{rma| tag=F |reference= {{cite book
|title=Phineas Gage: A Gruesome but True Story About Brain Science |publisher=Houghton Mifflin Harcourt |year=2002 |isbn=978-0-618-05252-3
|url=https://archive.org/details/phineasgagegrues00john |url-access=registration |last=Fleischman |first=J.
|ref=none
}} <!--limited preview-->
}}

{{Refend}}

'''For researchers and specialists'''
{{Refbegin|30em}}

{{rma| tag=B |reference= {{cite journal
|last=Barker |first=F. G. II |year=1995 |pmid=7897537 |url=http://mysois.uwm.edu/omeka/archive/files/b7cf786e3d97d4cf63ac3b7d14e1f88e.pdf |title=Phineas among the phrenologists: the American crowbar case and nineteenth-century theories of cerebral localization |journal=Journal of Neurosurgery |volume=82 |pages=672{{ndash}}82 |doi=10.3171/jns.1995.82.4.0672 |issue=4 |url-status=dead |archive-url=https://web.archive.org/web/20141006074853/http://mysois.uwm.edu/omeka/archive/files/b7cf786e3d97d4cf63ac3b7d14e1f88e.pdf |archive-date=October 6, 2014 }}
}}

{{rma| tag=B1 |reference= {{cite journal
|last=Bigelow |first=Henry Jacob |journal=[[American Journal of the Medical Sciences]]
|title=Dr. Harlow's Case of Recovery from the Passage of an Iron Bar through the Head
|url=https://books.google.com/books?id=pgMHAAAAcAAJ&pg=PA12-IA2
|date=July 1850 |number=39 |volume=20 |series=New series |pages=13{{ndash}}22
}}
}}

{{rma| tag=B2 |reference={{cite letter | author-mask=2 |first=Henry Jacob |last=Bigelow |recipient=M. Jewett |type=manuscript |subject=Your favor of April 29th is before me |date=May 12, 1868}} Records of the Warren Anatomical Museum, 1828{{ndash}}1892 (inclusive) (AA 192.5), Harvard Medical Library in the Francis A. Countway Library of Medicine.
}}

{{rma| tag=D |reference= {{cite book
|last=Draaisma|first=Douwe |title=Disturbances of the Mind|chapter-url=https://books.google.com/books?id=KPpUAwAAQBAJ
|year=2009|publisher=Cambridge University Press|isbn=978-1-139-93611-8
|chapter=Phineas Gage's posthumous stroll: the Gage matrix
}} {{closed access}} }}

{{rma| tag=F1 |reference= {{cite book
|last=Fuster |first=Joaquin M. |title=The prefrontal cortex
|publisher=Elsevier/Academic Press |year=2008 |page=172 |isbn=978-0-12-373644-4
|url=https://books.google.com/books?id=zuZlvNICdhUC&pg=PA172
}} {{closed access}}
}}

{{rma| tag=G |reference= {{cite book
|chapter=The Structured Event Complex and the Human Prefrontal Cortex |doi=10.1093/acprof:oso/9780195134971.003.0019
|title=Principles of Frontal Lobe Function |editor1=Stuss, D. T. |editor2=Knight, R. T.
|pages=292{{ndash}}310 |year=2002 |isbn=978-0-19-513497-1 |last1=Grafman |first1=J.
}} {{closed access}}
}}

{{rma| tag=G1 |reference= Gage, P. P. (1854). "Please deliver my iron bar to the bearer" (Note to unknown recipient). Records of the Warren Anatomical Museum, 1828{{ndash}}1892 (inclusive) (AA&nbsp;192.5), Box 1, Harvard Medical Library in the Francis A. Countway Library of Medicine.
}}

{{rma| tag=H |reference= {{cite journal
|last=Harlow |first=John Martyn |year=1868
|title=Recovery from the Passage of an Iron Bar through the Head
|journal=Publications of the Massachusetts Medical Society |volume=2|number=3
|pages=327{{ndash}}47
|url=https://en.wikisource.org/wiki/Recovery_from_the_passage_of_an_iron_bar_through_the_head
}} Reprinted: David Clapp&nbsp;& Son (1869) <small>[https://archive.org/stream/publications213mass#page/n361/mode/2up {{bracket|scan}}]<!--[[:File:Recovery_from_the_passage_of_an_iron_bar_through_the_head.djvu|[scan]]]--></small>}}<!--article cites give pg#s in terms of 1869 reprint, so probably should reverse positions in this cite of 1868, 1869 versions, making 1869 primary-->

{{rma| tag=H1 |reference= {{cite journal |last=Harlow |first=John Martyn |date=December 13, 1848 |volume=39 |title=Passage of an Iron Rod Through the Head |url=https://books.google.com/books?id=ArYEAAAAYAAJ&pg=PA389 |journal=[[Boston Medical and Surgical Journal]] |number=20 |pages=389{{ndash}}93 |doi=10.1056/nejm184812130392001   |df=mdy-all }} ([[s:Passage of an Iron Rod Through the Head|Transcription]])
}}

{{rma| tag=H2 |reference= {{cite journal |author-mask=2
|last=Harlow |first=John Martyn |date=January 17, 1849 |title=Medical Miscellany (letter dated January 3)
|journal=[[Boston Medical and Surgical Journal]] |volume=39 |number=25 |pages=506{{ndash}}7
|url=https://books.google.com/books?id=ArYEAAAAYAAJ&pg=PA506
}}
}}

{{rma| tag=K1 |reference= {{cite journal
|url=http://ist-socrates.berkeley.edu/~kihlstrm/SocialNeuroscience07.htm |last=Kihlstrom
|first=J. F. |year=2010 |title=Social neuroscience: The footprints of Phineas Gage
|journal=Social Cognition |volume=28 |pages=757{{ndash}}82 |doi=10.1521/soco.2010.28.6.757 |issue=6
|archive-url = https://web.archive.org/web/20141006172659/http://ist-socrates.berkeley.edu/~kihlstrm/SocialNeuroscience07.htm | archive-date = 2014-10-06
}}
}}

{{rma| tag=L |reference= {{cite news
|author=<!--anon-->|date=March 2010 |url=http://www.smithsonianmag.com/arts-culture/letters-41-7152623/
|title=Letters: Readers Respond to the January Issue. Picturing Phineas Gage (Editor's note) |page=4
|work=[[Smithsonian Magazine|Smithsonian]]
}}
* {{cite news
|last1=Lena |first1=M. L. |last2=Macmillan |first2=Malcolm B.
|date=March 2010 |url=http://www.smithsonianmag.com/arts-culture/letters-41-7152623/
|title=Letters: Readers Respond to the January Issue. Picturing Phineas Gage (Invited comment) |page=4<!--chk vol, issue, pg-->
|work=[[Smithsonian Magazine|Smithsonian]]
}}
}}

{{rma| tag=L1 |reference= {{cite journal
|last=Lena |first= M. L. |date=Spring 2018 | volume=56 |number=1
|title=The Navvy and the Navigator: Connecting Phineas Gage and Mark Twain's 'Mean Men'
|journal=Mark Twain Journal | pages=166–200
}}
}}

{{rma| tag=L2 |reference= {{cite book
|last=Luria |first= A. R. |year=1963 |translator=O. L. Zangwill
|title=Restoration of function after brain injury
|location=New York |publisher=Pergamon Press, Macmillan
}}
* {{cite book | author-mask=2
|last=Luria |first= A. R. |year=1973 |translator=Haigh Basil
|title=The working brain: an introduction to neuropsychology
|location=New York |publisher=Basic Books
}}
* {{cite book | author-mask=2
|last=Luria |first= A. R. |year=1979
|title=The making of mind: a personal account of Soviet psychology
| url=https://archive.org/details/makingofmind00luri
| url-access=registration
|publisher=Harvard University Press
|isbn=978-0-674-54326-3 |editor1=Michael Cole |editor2=Sheila Cole
}}
* {{cite book | author-mask=2
|last=Luria |first= A. R. |year=1980 |edition=2nd |translator=Haigh Basil
|title=Higher cortical functions in man
|location=New York |publisher=Basic Books
}}
* {{cite book | author-mask=2
|last=Luria |first= A. R. |year=1972 |translator=Lynn Solotaroff
|title=The man with a shattered world: the history of a brain wound
|publisher=Harvard University Press
}}
}}

{{rma| tag=K2 |reference= {{cite journal
|last1=Kotowicz |first1=Z. |doi=10.1177/0952695106075178 |pages=115{{ndash}}31 |year=2007
|title=The strange case of Phineas Gage |journal=History of the Human Sciences |volume=20 |issue=1
|s2cid=145698840 }} {{closed access}}
}}

{{rma| tag=M5 |reference= {{cite news
|last=Macmillan |first=Malcolm B. |year=1996 |pages=243{{ndash}}62 |title=Phineas Gage: A Case for All Reasons
|location=London |publisher=Erlbaum |work=Classic Cases in Neuropsychology
|editor1-last=Code |editor1-first=C. |editor2-last=Wallesch |editor2-first=C. W.
|editor3-last=Lecours |editor3-first=A. R. |editor4-last=Joanette |editor4-first=U.
}} }}

{{rma| tag=M6 |reference= {{cite journal |author-mask=2
|last1=Macmillan |first1=Malcolm B.
|title=Restoring Phineas Gage: A 150th Retrospective |doi=10.1076/0964-704X(200004)9:1;1-2;FT046
|journal=Journal of the History of the Neurosciences |volume=9 |issue=1
|pages=46{{ndash}}66 |year=2000 |pmid=11232349 |s2cid=2250377 }} {{closed access}}
}}

{{rma| tag=M7 |reference= {{cite journal |author-mask=2
|last1=Macmillan |first1=Malcolm B.
|title=John Martyn Harlow: Obscure Country Physician? |doi=10.1076/jhin.10.2.149.7254 |year=2001
|journal=Journal of the History of the Neurosciences |volume=10 |issue=2 |pages=149{{ndash}}62 |pmid=11512426
|s2cid=341061 }} {{closed access}}
}}

{{rma| tag=M8 |reference= {{cite journal |author-mask=2
|last1=Macmillan |first1=Malcolm B.
|title=Inhibition and Phineas Gage: Repression and Sigmund Freud |year=2004
|journal=Neuropsychoanalysis |volume=6|number=2|pages=181{{ndash}}92 |doi=10.1080/15294145.2004.10773459
|s2cid=145175407 }} {{closed access}}
}}

{{rma| tag=M9 |reference= {{cite web |author-mask=2
|url=http://brightbytes.com/phineasgage/more.html |last=Macmillan |first=Malcolm B. |date=July 2009
|title=More About Phineas Gage, Especially After the Accident
|access-date=2016-05-16|website=www.brightbytes.com
}}}}

{{rma| tag=M10 |reference= {{cite journal |author-mask=2
|last1=Macmillan |first1=Malcolm B. |last2=Lena |first2=M. L. |doi=10.1080/09602011003760527 |title=Rehabilitating Phineas Gage
|journal=Neuropsychological Rehabilitation |volume=20 |issue=5 |pages=641{{ndash}}58 |year=2010 |pmid=20480430 |s2cid=205655881
|df=mdy-all }}
}}

{{rma| tag=R |reference= {{cite journal
|last1=Ratiu |first1=P. |last2=Talos |first2=I. F. |last3=Haker |first3=S. |last4=Lieberman |pages=637{{ndash}}43
|first4=D. |last5=Everett |first5=P. |title=The Tale of Phineas Gage, Digitally Remastered |pmid=15165371
|doi=10.1089/089771504774129964 |journal=Journal of Neurotrauma |volume=21 |issue=5 |year=2004
}} {{closed access}}<!--confusing ratiu cites and page #s need checking-->
}}

{{rma| tag=R1 |reference= {{cite journal |author-mask=2
|last1=Ratiu |first1=P. |last2=Talos |first2=I. F. |doi=10.1056/NEJMicm031024 |pmid=15575047
|title=The Tale of Phineas Gage, Digitally Remastered |journal=New England Journal of Medicine
|volume=351 |issue=23 |page=e21 |year=2004
}}
}}

{{rma| tag=T1 |reference= {{cite journal
|last1=Thiebaut de Schotten |first1=M. |last2=Dell'Acqua |first2=F. |last3=Ratiu |first3=P.
|last4=Leslie |first4=A. |last5=Howells |first5=H. |last6=Cabanis |first6=E.
|last7=Iba-Zizen |first7=M. T. |last8=Plaisant |first8=O. |last9=Simmons |first9=A.
|last10=Dronkers |first10=N. F. |last11=Corkin |first11=S. |last12=Catani |first12=M.
|year=2015 |pages=1{{ndash}}16
|title=From Phineas Gage and Monsieur Leborgne to H.M.: Revisiting Disconnection Syndromes
|journal=Cerebral Cortex |doi=10.1093/cercor/bhv173 |pmid=26271113 |pmc=4635921 |volume=25
|issue=12 }}
}}

{{rma| tag=T2 |reference= {{cite journal
|last1=Tyler |first1=K. L. |last2=Tyler |first2=H. R. |year=1982 |volume=32 |page=A191
|title=A 'Yankee Invention': the celebrated American crowbar case |journal=Neurology
}} {{closed access}} Images reproduced in [[#CITEREFM|Macmillan (2000)]], App. E.
}}

{{rma| tag=V |reference= {{cite journal
|last1=Van Horn |first1=J. D. |last2=Irimia |first2=A. |last3=Torgerson |first3=C. M.
|last4=Chambers |first4=M. C. |last5=Kikinis |first5=R. |last6=Toga |first6=A. W.
|title=Mapping Connectivity Damage in the Case of Phineas Gage |doi=10.1371/journal.pone.0037454
|journal=PLOS ONE |volume=7 |issue=5 |page=e37454 |year=2012 |pmid=22616011 |pmc=3353935
|bibcode=2012PLoSO...737454V |doi-access=free }}
}}

{{rma| tag=W |reference= {{cite journal
|last1=Wilgus |first1=J |last2=Wilgus |first2=B |year=2009 |title=Face to Face with Phineas Gage
|pmid=20183215
|journal=Journal of the History of the Neurosciences |volume=18 |issue=3 |pages=340{{ndash}}45 |doi=10.1080/09647040903018402
|s2cid=19347145 }} {{closed access}}
}}

{{rma| tag=W1 |reference= {{cite journal |author-mask=2 |author-mask2=2
|last1=Wilgus |first1=J |last2=Wilgus |first2=B |date=July{{ndash}}September 2009 |title=Phineas Gage{{snd}}Hiding in Plain Sight
|journal=The Daguerreian Society Newsletter |volume=21 |issue=3 |pages=6{{ndash}}9
}} }}

{{rma| tag=W2 |reference= {{cite web |author-mask=2 |author-mask2=2
|last1=Wilgus |first1=J |last2=Wilgus |first2=B |year=2009 |title=Meet Phineas Gage |website=www.brightbytes.com
|url=http://www.brightbytes.com/phineasgage/index.html |access-date=2016-05-16
}}
}}

{{rma| tag=W3 |reference= {{cite web |author-mask=2 |author-mask2=2
|last1=Wilgus |first1=J |last2=Wilgus |first2=B |year=2010 |title=A New Image of Phineas Gage|website=www.brightbytes.com
|url=http://www.brightbytes.com/phineasgage/new_image.html |access-date=2016-05-16
}}
}}

{{Refend}}
'''Other sources cited'''
{{Reflist |30em |refs=

{{refn |name=accident_excerpts
|Excerpted from Williams's and Harlow's statements in: [[#CITEREFH1|Harlow (1848)]], pp. 390{{ndash}}93; [[#CITEREFB1|Bigelow (1850)]], p. 16; [[#CITEREFH|Harlow (1868)]], pp. 7{{ndash}}10.
}}

{{refn |name=ahlstrom|{{cite news
|title=Study finds blow to head may cause psychopathic behaviour
|first=Dick|last= Ahlstrom |newspaper=The Irish Times|date= October 19, 1999|page=2
}} }}

{{refn |name=ama_standing|{{cite journal
|author=American Medical Association |year=1850 |page=345
|journal=The Transactions of the American Medical Association
|title=Report of the Standing Committee on Surgery |location=Philadelphia |publisher=T.K. and P.G. Collins
|volume=3 |url=https://archive.org/details/transactionsame45assogoog/page/n349
}}}}

{{refn |name=amer_phren |{{cite journal
|author=<!--anon--> |journal=American Phrenological Journal and Repository of Science, Literature, and General Intelligence
|title=A most remarkable case |volume=13 |number=4
|url=https://books.google.com/books?id=Ao4eAQAAMAAJ&pg=PA89 |date=April 1851 |at=p. 89, col. 3
}}}}

{{refn |name=anonymous_ngray
|author=<!--anon--> |''Volume 3: Lone Mountain register, 1850{{ndash}}1862'', Halsted N. Gray{{snd}}Carew & English Funeral Home Records (SFH 38), San Francisco History Center, San Francisco Public Library. p. 285.
}}<!--chk exact cite/name of merged firm, and formalize cite-->

{{refn |name=anonymous_bmsj1868 |{{cite journal
|author=<!--anon--> |title=Reports of medical societies. Annual meeting of the Massachusetts Med. Society{{snd}}Second day|journal=[[Boston Medical and Surgical Journal]] |date=June 11, 1868 |url=https://books.google.com/books?id=3P4TAAAAYAAJ&pg=PA301
|volume=1 |series=New series |pages=301{{ndash}}6 |issue=19
|doi=10.1056/NEJM186806110781906
|s2cid=4747463}} }}

{{refn |name=anonymous_bmsj1869_1 |{{cite journal
|author=<!--anon--> |title=Bibliographical Notices |journal=[[Boston Medical and Surgical Journal]] |date=March 18, 1869
|volume=3 |series=New series |pages=116{{ndash}}17 |issue=7
|url=https://books.google.com/books?id=T8QEAAAAYAAJ&pg=PA116
}}}}

{{refn |name=anonymous_bmsj1869_2 |{{cite journal
|author=<!--anon--> |title=Medical Intelligence. Extraordinary Recovery |journal=[[Boston Medical and Surgical Journal]] |date=April 29, 1869 |volume=3 |series=New series |pages=230{{ndash}}31 |issue=13 |url=https://books.google.com/books?id=T8QEAAAAYAAJ&pg=PA230
}} }}

{{refn |name=anonymous_bostonpost |{{cite news
|author=<!--anon--> |date=September 21, 1848 |work=Boston Post |title=Horrible Accident|postscript=none
}} (crediting ''Ludlow (Vermont) Free Soil Union'', unknown date).}}

{{refn |name=anonymous_mercury|{{cite news
|author=<!---anon-->|work=[[Vermont Mercury]] |location=[[Woodstock, Vermont]] |title=Wonderful Accident
|at=p. 2 col. 3 |date=September 22, 1848
}} Transcribed in [[#CITEREFM|Macmillan (2000)]], pp. 36{{ndash}}7.
}}

{{refn |name=anonymous_national_eagle|{{cite news
|author=<!--anon-->|date=March 29, 1849 |work=National Eagle |at=p. 2, col. 2
|location=Claremont, New Hampshire |title=Incredible, But True Every Word
}} Reprinted: ''True Democrat and Granite State Whig'' (Lebanon, New Hampshire), April 6, 1849, p.&nbsp;1, col.&nbsp;7. Transcribed in [[#CITEREFM|Macmillan (2000)]], pp. 40{{ndash}}1.
}}

{{refn |name=austin |{{cite book
|last=Austin |first=K. A. |year=1977
|title=A Pictorial History of Cobb and Co.: The Coaching Age in Australia, 1854{{ndash}}1924
|publisher=Rigby |location=Sydney |isbn=978-0-7270-0316-4
}} }}

{{refn |name=background |
[[#CITEREFH1|Harlow (1848)]], p. 389; [[#CITEREFB1|Bigelow (1850)]], p. 13; [[#CITEREFH|Harlow (1868)]], p. 4.
}}

{{refn |name=benderly |{{cite journal
|last=Benderly |first=Beryl Lieff | date=September 2012 |title=Psychology's tall tales
|url=http://www.apa.org/gradpsych/2012/09/tall-tales.aspx|page=20
|journal=GradPSYCH
}}}}

{{refn |name=bower |{{cite journal
|title=The Social Brain: New Clues from Old Skull |first= B. |last= Bower |jstor=3978044
|journal=Science News |volume=145 |number=21 |date=May 21, 1994 |pages=326{{ndash}}27 |doi=10.2307/3978044
}} {{closed access}} }}

{{refn | name=bring_me |{{cite magazine
|title=Bring Me the Head of Phineas Gage|magazine=Boundless: A Science Comics Anthology
|volume=1|year=2016|last1=Barnes |first1=E. J.|last2=Lee|first2=L. B.|isbn=978-0-9903433-5-6
|url=http://boundlesscomics.tumblr.com/post/145332268645/meet-our-contributors-e-j-barnes-and-lb-lee-e
}} {{closed access}} }}

{{refn |name=wife |
{{cite book|last=Moffatt|first=Gregory K.|title=A Violent Heart: Understanding Aggressive Individuals|page=6
|url=https://books.google.com/books?id=d8lpAEI1mP0C&pg=PA6|year=2002|publisher=Greenwood Publishing Group|isbn=978-0-275-97336-0
}}
* [[#anonymous northstar|Anonymous (1848)]]; [[#CITEREFM|Macmillan (2000)]], pp. 39, 319, 327.
}}

{{refn |name=sexuality|
{{cite book
|last1=Beaumont |first1=Graham |last2=Kenealy |first2=Pamela |last3=Rogers |first3=Marcus |date=1991 |publisher=Wiley
|title=The Blackwell Dictionary of Neuropsychology |url=https://books.google.com/books?id=g5ijQgAACAAJ
|isbn=978-0-631-17896-5 }} {{closed access}}
* {{cite book
|last1=Crider |first1=A. B. |last2=Goethals |first2=G. R. |last3=Kavanagh |first3=R. D.
|last4=Solomon |first4=P. R. |year=1983 |title=Psychology |publisher=Scott, Foresman
}}
* {{cite book
|last=Myers |first=David G. |url=https://archive.org/details/psychology00myer04|url-access=registration <!--get pg#-->
|year=1995 |publisher=Worth Publishers |isbn=978-0-87901-644-9 |title=Psychology
}} {{closed access}}
* [[#CITEREFM|Macmillan (2000)]], pp. 319, 327{{ndash}}28
}}

{{refn |name=forethought|
[[#damasio1994|Damasio (1994)]], pp. 11, 51; [[#CITEREFM|Macmillan (2000)]], pp. 119, 331.
}}

{{refn |name=employment|
{{cite book |last=Altrocchi |first=John |year=1980 |title=Abnormal Behavior |publisher=Harcourt, Brace, Jovanovich |isbn=978-0-15-500370-5 |url=https://archive.org/details/abnormalbehavior0000altr }}
* {{cite book
|last1=Groves |first1=Philip M. |last2=Schlesinger |first2=K. |year=1982 |location=Dubuque, Iowa
|title=Introduction to Biological Psychology |edition=2nd |publisher=Brown
}}
* {{cite book
|last=Kalat |first=James W. |year=1981 |title=Biological Psychology |publisher=Wadsworth |location=Belmont, California
}}
* {{cite book
|last=Lahey |first=B. B. |year=1992 |page=63 |title=Psychology: An Introduction |edition=4th |location=Dubuque, Iowa |publisher=Brown
}}
* {{cite book
|last=Morris |first=C. G. |year=1996 |title=Psychology: An Introduction |url=https://archive.org/details/psychologyintrod00morr |url-access=registration |edition=9th |publisher=Prentice-Hall
|isbn=978-0-13-432972-7 }}
* {{cite book
|last=Smith |first=A. |year=1985 |title=The Body |location=Harmondsworth, England |publisher=Penguin
}}
* [[#CITEREFM|Macmillan (2000)]], pp. 107, 323.
}}

{{refn |name=irresponsibility|
{{cite news |ref=blakeslee
|last=Blakeslee |first=Sandra |date=May 24, 1994 |page=C1
|title=Old Accident Points to Brain's Moral Center |work=[[The New York Times]]
}}
* [[#damasio etal1994|Damasio et al. (1994)]], p. 1102; [[#CITEREFM|Macmillan (2000)]], p. 116.
}}

{{refn |name=aggressiveness|
{{cite book
|last=Dimond |first=Stuart J. |year=1980 |location=London |publisher=Butterworths
|title=Neuropsychology: A Textbook of Systems and Psychological Functions of the Human Brain
}}
* [[#CITEREFM|Macmillan (2000)]], pp. 321, 331.
}}

{{refn |name=vagrancy|
{{cite book
|last=Restak |first=Richard M. |title=The Brain |url=https://archive.org/details/brain00rest |url-access=registration |publisher=Bantam Books |year=1984
|isbn=978-0-553-05047-9 }}
* {{cite book
|last=Tow |first=Peter Macdonald |year=1955 |location=London & New York |publisher=Oxford University Press
|title=Personality changes following frontal leucotomy: a clinical and experimental study of the functions of the frontal lobes in man. With a foreword by Sir Russell Brain
}}
* [[#CITEREFM|Macmillan (2000)]], p. 323.
}}

{{refn |name=drifting|
{{cite book
|last=Blakemore |first=Colin |title=Mechanics of the mind |url=https://archive.org/details/mechanicsofmind00blak |url-access=registration |publisher=Cambridge University Press |year=1977
}}
* {{cite book
|last=Brown |first=H. |year=1976 |location=New York |publisher=Oxford University Press
|title=Brain and Behavior: A Textbook of Physiological Psychology
}}
* {{cite book
|last=Hart |first=Leslie A. |year=1975 |publisher=Basic Books
|title=How the Brain Works: A New Understanding of Human Learning, Emotion, and Thinking
|isbn=978-0-465-03102-3 |url=https://archive.org/details/howbrainworksn00hart |url-access=registration }}
* [[#CITEREFM|Macmillan (2000)]], pp. 316, 323.
}}

{{refn |name=drinking|
{{cite journal
|last=Hughes |first=C. D. |year=1897 |pages=315{{ndash}}23 |title=Neurological progress in America
|journal=Journal of the American Medical Association |number=7 |volume=29 |doi=10.1001/jama.1897.02440330015001e
|url=https://zenodo.org/record/1447257 }} {{closed access}}
* {{cite book |last=Smith |first=A. |year=1984 |title=The Mind |location=London |publisher=Hodder and Stoughton
}}
* {{cite book
|last=Wilson |first=Andrew |date=January 1879 |pages=68–85 |title=The old phrenology and the new
|url=https://books.google.com/books?id=MRQJAAAAIAAJ&pg=PA68 |volume=CCXLIV |work=Gentleman's Magazine
}}
* [[#CITEREFM|Macmillan (2000)]], pp. 118, 316, 321.
}}

{{refn |name=lying|
[[#blakeslee|Blakeslee (1994)]]; [[#CITEREFM|Macmillan (2000)]], pp. 119, 321.
}}

{{refn |name=brawling|
[[#damasio1994|Damasio (1994)]], p. 9; [[#CITEREFM|Macmillan (2000)]], p. 119.
}}

{{refn |name=bullying|
{{cite book
|last=Sdorow |first=Lester |year=1990 |title=Psychology |url=https://archive.org/details/psychology00sdor |url-access=registration |location=Dubuque, Iowa |publisher=Brown
|isbn=978-0-697-07649-6 }}
* [[#CITEREFM1|Macmillan (2008)]], p. 830; [[#CITEREFM|Macmillan (2000)]], p. 321.
}}

{{refn |name=psychopathy|
{{cite book
|last=Changeux |first=Jean-Pierre |year=1985 |pages=158{{ndash}}59 |title=Neuronal Man: The Biology of the Mind
|others=Tr. by Laurence Garey |publisher=Pantheon Books |edition=1st American
}}
* [[#CITEREFM|Macmillan (2000)]], p. 321.
}}

{{refn |name=idiot|
[[#blakeslee|Blakeslee (1994)]]; [[#CITEREFM|Macmillan (2000)]], p. 39.
}}

{{refn|name=lobotomy|
{{cite book
|last=Carlson |first=N. R. |title=Physiology of Behavior |url=https://archive.org/details/physiologyofbeh000carl |url-access=registration |year=1994 |page=[https://archive.org/details/physiologyofbeh000carl/page/341 341] |publisher=Allyn and Bacon |isbn=978-0-205-07264-4
}}
* {{cite book
|title=Cutting the mind: origins of psychosurgery |first1=Matheus |last1=Arts |first2= Philip |last2=Michielsen
|location=Leuven |publisher=Acco |year=2012|isbn=978-9033486388 |page=40
}}
* [[#CITEREFM|Macmillan (2000)]], pp. 246, 252{{ndash}}53nn9,10.
}}

{{refn |name=bennett |{{cite journal
|last=Bennett |first=W. |date=July{{ndash}}August 1987 |pages=24{{ndash}}31
|title=Dr. Warren's Possessions |journal=Harvard Magazine |volume=89 |number=6
|pmid=11617033
}} }}

{{refn |name=bsmi |
[[Boston Society for Medical Improvement]] (1849). ''Records'' '''6'''. November 10. pp. 103–4.<!--need full citation-->
}}

{{refn |name=bramwell |{{cite journal
|last1=Bramwell |first1=B. |doi=10.1136/bmj.1.1425.835
|title=The Process of Compensation and some of its Bearings on Prognosis and Treatment
|journal=BMJ |volume=1 |issue=1425 |pages=835{{ndash}}40 |year=1888 |pmid=20752265 |pmc=2197878
}}}}

{{refn |name=campbell |{{cite journal |last=Campbell |first=H. F. |year=1851 |title=Injuries of the Cranium – Trepanning |journal=Ohio Medical & Surgical Journal |volume=4 |number=1 |pages=20{{ndash}}24
|title-link=Trepanning }} (crediting the ''Southern Medical&nbsp;& Surgical Journal'', unknown date). }}

{{refn |name=cobb1940 |{{cite journal
|last=Cobb |first=Stanley |year=1940 |title=Review of neuropsychiatry for 1940
|journal=Archives of Internal Medicine |volume=66 |issue=6 |pages=1341{{ndash}}54
|doi=10.1001/archinte.1940.00190180153011
}} {{closed access}} }}

{{refn | name=cobb1943|{{cite book
|last=Cobb |first=Stanley |year=1943 |title=Borderlands of psychiatry
|url=https://archive.org/details/borderlandsofpsy0000cobb |url-access=registration |publisher=Harvard Univ. Press.<!--need pg number-->
}} }}

{{refn |name=cooter|{{cite book
|last=Cooter |first=Roger |year=1984 |page=[https://archive.org/details/culturalmeaningo00coot/page/20 20]
|title=The Cultural Meaning of Popular Science: Phrenology and the Organization of Consent in Nineteenth-century Britain
|publisher=Cambridge University Press |isbn=978-0-521-22743-8 |url=https://archive.org/details/culturalmeaningo00coot
|url-access=registration }} }}

{{refn |name=butler|{{cite web
|url=http://www.cromwellbutlers.com/fam_tree/p_gage.htm
|last=Macmillan|first=Malcolm|title=Phineas Gage: The claim of Williams' priority
|website=Butler Family
}}}}

{{refn|name=daffner|{{cite book
|work=Handbook of Clinical Neurology|volume=88|series=3rd|title=Neuropsychology and behavioral neurology|editor-first1= G.|editor-last1=Goldenberg|editor-first2=B. L. |editor-last2=Miller|year=2008 |publisher=Elsevier B.V.|chapter=The dysexecutive syndromes|last1=Daffner|first1=Kirk R.|last2=Searl|first2=Meghan M.
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{{refn |name=damasioA_somatic|{{cite journal
|title=The Somatic Marker Hypothesis and the Possible Functions of the Prefrontal Cortex [and Discussion]
|first1=Antonio R. |last1=Damasio |first2=B. J. |last2=Everitt |first3=D. |last3=Bishop
|journal=Philosophical Transactions: Biological Sciences |date=October 29, 1996 |pages=1413{{ndash}}20
|volume=351 |number=1346 |series=Executive and Cognitive Functions of the Prefrontal Cortex
|jstor=3069187 |doi=10.1098/rstb.1996.0125 |pmid=8941953|s2cid=1841280
}} {{closed access}} }}

{{refn |name=damasioA_neuropsychology |{{cite book
|last1=Damasio |first1=A. R.|author-link1=Antonio Damasio |last2=Van Hoesen |first2=G. W.
|title=Emotional disturbances associated with focal lesions of the limbic frontal lobe
|url=https://books.google.com/books?id=Ia13QgAACAAJ |work=Neuropsychology of Human Emotion
|year=1983 |publisher=Guilford Press|location=New York |isbn=978-0-89862-200-3
|pages=85{{ndash}}110 |editor1=Paul Satz |editor2=Kenneth M. Heilman
}} {{closed access}} }}

{{refn |name=damasioA_descartes |{{cite book |ref=damasio1994
|last=Damasio |first=Antonio R. |author-link=Antonio Damasio |publisher=Quill
|title=Descartes' error: emotion, reason, and the human brain |year=1994
|url=https://books.google.com/books?id=MocSdi6LXCkC|isbn=978-0-380-72647-9
}} {{closed access}} }}

{{refn |name=damasioH_return |{{cite journal|author-link4=Albert Galaburda
|last1=Damasio |first1=H. |last2=Grabowski |first2=T. |last3=Frank |first3=R. |last4=Galaburda |first4=A. M. |last5=Damasio|first5=A. R.
|title=The return of Phineas Gage: Clues about the brain from the skull of a famous patient
|doi=10.1126/science.8178168 |journal=Science |volume=264 |issue=5162 |pages=1102{{ndash}}5 |year=1994 |pmid=8178168
|bibcode=1994Sci...264.1102D |s2cid=206630865 }} {{closed access}} }}

{{refn |name=apex|{{cite book
|last=Burton |first=Warren |author-link=Warren Burton (1800{{ndash}}1866) |location=New York |page=[https://archive.org/details/unclesamsrecomm00burgoog/page/n229 217]
|title=Uncle Sam's recommendation of phrenology to his millions of friends in the United States: In a series of not very dull letters
|url=https://archive.org/details/unclesamsrecomm00burgoog |year=1842 |publisher=Harper and Brothers
}}
* {{cite news
|last=Davidson |first=James Wood |author-link=James Wood Davidson
|title=How We Read Each Other. Phrenology |publisher=J.J. Toon |location=Atlanta
|url=https://books.google.com/books?id=U3RHAAAAYAAJ&pg=PA559 |volume=2 |date=July 1866 |number=2
|pages=557{{ndash}}62 at 559 |work=Scott's Monthly Magazine
}}
* {{cite news
|title=Phrenology for "Tim Bobbin" |number=624 |url=https://books.google.com/books?id=yQwAAAAAMAAJ&pg=PA302
|volume=XXIV |page=302 |date=February 13, 1897
|work=Fibre & Fabric: A Record of American Textile Industries in the Cotton and Woolen Trade
}}}}

{{refn |name=deaths|{{cite news
|work=New Hampshire Statesman |date=July 21, 1860 |number=2042 |at=col. D |title=Deaths |location=Concord, New Hampshire
}} }}

{{refn |name=departing|{{cite news
|work=Daily Alta California|date=December 25, 1867 |at=p. 2 col. 4 |title=A Departing Supervisor
}} }}

{{refn |name=dupuy1873|{{cite book
|last=Dupuy |first=Eugene |year=1873
|title=Examen de quelques points de la physiologie du cerveau
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}} }}

{{refn |name=dupuy1877 |{{cite journal
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}}}}

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{{refn |name=eliot |{{cite book
|editor-last=Eliot |editor-first=Samuel Atkins |year=1911
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{{refn |name=ferrier1877_9 |
Ferrier, David (1877–79). ''Correspondence with Henry Pickering Bowditch''. H&nbsp;MS&nbsp;c5.2, Harvard Medical Library in the Francis A. Countway Library of Medicine. Transcribed in [[#CITEREFM|Macmillan (2000)]], pp. 464–65.
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{{refn |name=ferrier1878 |{{cite journal |last=Ferrier |first=David |year=1878
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}}}}

{{refn |name=fingers
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}}

{{refn |name=folsom |{{cite news |last=Folsom |first=A. C. |work=Pacific Medical and Surgical Journal |title=Extraordinary Recovery from Extensive Saw-Wound of the Skull |date=May 1869 |volume=2|pages=550{{ndash}}55
}} }}

{{refn |name=fowler |{{cite book
|last=Fowler |first=O. S. |year=1838 |page=6
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* {{cite book
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{{refn|name=goldenberg|{{cite journal
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}}

{{refn |name=griggs |{{cite journal
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{{refn|name=hamilton |{{cite journal
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{{refn |name=hammond|{{cite book
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{{refn |name=hayward |{{cite journal
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{{refn |name=heart |{{cite book
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{{refn |name=warren_index|
[https://collections.countway.harvard.edu/onview/exhibits/show/beyond-the-bone-box/item/25397 "An iron bar that had been driven through a man's head."] Catalog of the Museum, Index, undated. Series XXXIX. Miscellaneous specimens (page 179). Warren Anatomical Museum records, {{nobr|RG M-CL02.01}}, Box: 10, Folders: 6, 7. Center for the History of Medicine (Francis A. Countway Library of Medicine). [https://id.lib.harvard.edu/ead/c/med00145c00538/catalog] [https://id.lib.harvard.edu/ead/c/med00145c00539/catalog]
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}}}}

{{refn |name=jarrett1 |{{cite journal |first=Christian |last=Jarrett |title=Neuroscience still haunted by Phineas Gage |date=May 2012 |journal=PLOS ONE |volume=7 |issue=5 |page=e37454 |doi=10.1371/journal.pone.0037454 |pmid=22616011 |pmc=3353935 |bibcode=2012PLoSO...737454V |doi-access=free }}}}

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{{refn |name=jewett |{{cite journal
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}}}}

{{refn |name= larner |{{cite journal |url=http://www.acnr.co.uk/pdfs/volume2issue3/v2i3history.pdf |volume=2 |number=3 |date=July{{ndash}}August 2002 |page=26 |title=Phineas Gage and the beginnings of neuropsychology |first2=John Paul |last2=Leach |first1=Andrew |last1=Larner |journal=Advances in Clinical Neuroscience and Rehabilitation |access-date=2014-12-13  |archive-date=2016-04-09  |archive-url=https://web.archive.org/web/20160409034950/http://www.acnr.co.uk/pdfs/volume2issue3/v2i3history.pdf |url-status=dead }}}}

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{{refn|name=mann|{{cite book
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{{refn |name=merwin |{{cite book
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{{refn |name=memoir_hjb |{{cite book
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{{refn |name=northcarolina |{{cite journal
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{{refn |name=nyt_additional |{{cite news
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{{refn|name=pott|{{cite book
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{{refn|name=rotarian|{{cite magazine
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{{refn |name=warren_phineas_gage |{{cite web
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 |title        = The Phineas Gage Case
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 |publisher    = Francis A. Countway Library (Harvard Medical School). Center for the History of Medicine. Warren Anatomical Museum
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 |archive-date = August 14, 2014
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}}}}

{{refn |name=raeburn | {{cite journal
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{{refn |name=sacks |{{cite book
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}} {{closed access}} }}

{{refn |name=silvestro |{{cite web
|url=https://hms.harvard.edu/news/new-view-phineas-gage | website=Harvard Medical School News
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}} }}

{{refn |name=smithS_carey |{{cite news
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|last=Smith |first=Stephen |work=Boston Globe |date=July 22, 2009 <!--get pg#-->
|title=Icon, revealed: Newly discovered image offers fresh insights about medical miracle
}} {{closed access}}
* {{cite news
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}} {{closed access}}
}}

{{refn |name=smithW |{{cite news
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}}}}

{{refn |name=stuss |{{cite journal
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{{refn|name=hockenbury |{{cite book
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{{refn|name=steegmann|{{Cite journal
|journal=Surgery |date=December 1962 |volume=52|number=6|page=952{{ndash}}58 |pmid=13983566
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}} {{closed access}} }}

{{refn |name=sutton |{{cite journal
|last=Sutton |first=W. L. |title=A Cent<!--<<DO NOT AMERICANISE>>-->r<!--<<DO NOT AMERICANISE>>-->e<!--<<DO NOT AMERICANISE>>--> Shot
|journal=[[Boston Medical and Surgical Journal]] |volume=43 |number=12|page=241 |date=October 23, 1850
|url=https://books.google.com/books?id=r8o9AQAAMAAJ&pg=PA241
}}}}

{{refn |name=swetland |{{cite book
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}} }}

{{refn|name=turner |{{cite book|last=Turner|first=Eric Anderson|title=Surgery of the mind|url=https://books.google.com/books?id=oIpsAAAAMAAJ|year=1982|publisher=Carmen Press|location=Birmingham|isbn=978-0-946179-00-8|page=13
}} {{closed access}} }}

{{refn |name=vanderkloot|{{cite book
|last=Van der Kloot |first=William G. |year=1974 |page=289
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}}}}

{{refn |name=WAM03106
| An iron bar, that was driven through a man's head (Tamping iron of Phineas Gage). Warren Anatomical Museum (WAM&nbsp;03106), Harvard Medical Library in the Francis A. Countway Library of Medicine.
}}

{{refn |name=work
| [[#CITEREFM|Macmillan (2000)]], pp. 119, 316, 323; [[#CITEREFM1|Macmillan (2008)]], p. 830; [[#CITEREFK2|Kotowicz]], p. 130n6; [[#CITEREFD|Draaisma]], p. 77.
}}

{{refn |name=yakovlev |{{cite journal
|title=The 'Crowbar Skull' and {{sic|hide=y|Mementoes}} of 'Phrenological Hours'
|pages=19{{ndash}}24 |journal=Harvard Medical Alumni Bulletin
|volume=33 |date=October 1958 |number=1 |last=Yakovlev |first=Paul I.
|url=https://archive.org/stream/harvardmedicalal33harv/harvardmedicalal33harv_djvu.txt
}}}}

<!--<<end reflist-->}}

==External links==
{{Wikisource-author}}
{{Commons}}
* [https://www.uakron.edu/gage/ Phineas Gage information page] by the Center for the History of Psychology at the [[University of Akron]]
*[https://collections.countway.harvard.edu/onview/exhibits/show/beyond-the-bone-box/the-case-of-phineas-gage Case of Phineas Gage] at the [[Center for the History of Medicine]]
*[https://countway.harvard.edu/center-history-medicine/collections/notable-holdings Skull, life cast, and tamping iron of Phineas Gage] {{Webarchive|url=https://web.archive.org/web/20211205080138/https://countway.harvard.edu/center-history-medicine/collections/notable-holdings |date=2021-12-05  }} at the [[Warren Anatomical Museum]] of the [[Harvard Medical School]]
*[https://3dprint.nih.gov/discover/3dpx-003118 Skull of Phineas Gage] at the [[National Institutes of Health]] 3D print exchange

{{Authority control}}

{{DEFAULTSORT:Gage, Phineas}}
[[Category:1823 births]]
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[[Category:Frontal lobe]]
[[Category:History of neuroscience]]
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[[Category:People with traumatic brain injuries]]
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