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{{Short description|Protein found in humans}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Kruppel-like factor 13''', also known as '''KLF13''', is a [[protein]] that in humans is encoded by the ''KLF13'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF13 Kruppel-like factor 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621| accessdate = }}</ref><ref name="pmid10415854">{{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x }}</ref><ref name="pmid10023774"/>
'''Kruppel-like factor 13''', also known as '''KLF13''', is a [[protein]] that in humans is encoded by the ''KLF13'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF13 Kruppel-like factor 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621}}</ref><ref name="pmid10415854">{{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x | bibcode = 1999NYASA.880...94C | s2cid = 7618847 | doi-access = free }}</ref><ref name="pmid10023774"/>


There is some evidence for ''KLF13'' having a role in obesity. A methylation site, cg07814318, within the first [[intron]] of ''KLF13'' has been associated with obesity and orexigenic processes.<ref name="pmid28194012">{{cite journal | vauthors = Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB | title = A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. | journal = Int J Obes (Lond) | volume = 43 | issue = 6 | pages = 990–994 | date = 14 Feb 2017 | pmid = 28194012 | doi = 10.1038/ijo.2017.43 }}</ref> [[Ghrelin]] levels also positively correlated with methylation levels of cg07814318.<ref name="pmid28194012" /> Moreover, expression levels of ''KLF13'' were decreased and increased in the brains of starved and obese mice, respectively.<ref name="pmid28194012" />
There is some evidence for ''KLF13'' having a role in obesity. A methylation site, cg07814318, within the first [[intron]] of ''KLF13'' has been associated with obesity and orexigenic processes.<ref name="pmid28194012">{{cite journal | vauthors = Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB | title = A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. | journal = Int J Obes (Lond) | volume = 43 | issue = 6 | pages = 990–994 | date = 14 Feb 2017 | pmid = 28194012 | doi = 10.1038/ijo.2017.43 | s2cid = 52835570 }}</ref> [[Ghrelin]] levels also positively correlated with methylation levels of cg07814318.<ref name="pmid28194012" /> Moreover, expression levels of ''KLF13'' were decreased and increased in the brains of starved and obese mice, respectively.<ref name="pmid28194012" />


== Function ==
== Function ==
Line 8: Line 9:
KLF13 belongs to a family of [[transcription factors]] that contain 3 classical [[zinc finger]] DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.<ref name="entrez" /><ref name="pmid11087666">{{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }}</ref>
KLF13 belongs to a family of [[transcription factors]] that contain 3 classical [[zinc finger]] DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.<ref name="entrez" /><ref name="pmid11087666">{{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }}</ref>


KLF13 was first described as the [[RANTES]] factor of late activated [[T lymphocyte]]s (RFLAT)-1.<ref name="pmid10023774">{{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 }}</ref> It regulates the expression of the [[chemokine]] RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of [[Bcl-xL]] expression.<ref name="pmid10023774" /><ref name="pmid11138780">{{cite journal | vauthors = Song A, Nikolcheva T, Krensky AM | title = Transcriptional regulation of RANTES expression in T lymphocytes | journal = Immunological Reviews | volume = 177 | issue = 1 | pages = 236–45 | date = Oct 2000 | pmid = 11138780 | doi = 10.1034/j.1600-065X.2000.17610.x }}</ref><ref name="pmid12093895">{{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }}</ref><ref name="pmid12050170">{{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 }}</ref><ref name="pmid17442931">{{cite journal | vauthors = Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM | title = Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo | journal = Journal of Immunology | volume = 178 | issue = 9 | pages = 5496–504 | date = May 2007 | pmid = 17442931 | pmc = 2664650 | doi = 10.4049/jimmunol.178.9.5496 }}</ref><ref name="pmid17513757">{{cite journal | vauthors = Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM | title = Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 7081–7 | date = Jun 2007 | pmid = 17513757 | pmc = 2674583 | doi = 10.4049/jimmunol.178.11.7081 }}</ref><ref name="pmid17074812">{{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }}</ref>
KLF13 was first described as the [[RANTES]] factor of late activated [[T lymphocyte]]s (RFLAT)-1.<ref name="pmid10023774">{{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 | doi-access = free }}</ref> It regulates the expression of the [[chemokine]] RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of [[Bcl-xL]] expression.<ref name="pmid10023774" /><ref name="pmid11138780">{{cite journal | vauthors = Song A, Nikolcheva T, Krensky AM | title = Transcriptional regulation of RANTES expression in T lymphocytes | journal = Immunological Reviews | volume = 177 | issue = 1 | pages = 236–45 | date = Oct 2000 | pmid = 11138780 | doi = 10.1034/j.1600-065X.2000.17610.x | s2cid = 30184294 }}</ref><ref name="pmid12093895">{{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }}</ref><ref name="pmid12050170">{{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 | doi-access = free }}</ref><ref name="pmid17442931">{{cite journal | vauthors = Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM | title = Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo | journal = Journal of Immunology | volume = 178 | issue = 9 | pages = 5496–504 | date = May 2007 | pmid = 17442931 | pmc = 2664650 | doi = 10.4049/jimmunol.178.9.5496 }}</ref><ref name="pmid17513757">{{cite journal | vauthors = Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM | title = Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 7081–7 | date = Jun 2007 | pmid = 17513757 | pmc = 2674583 | doi = 10.4049/jimmunol.178.11.7081 }}</ref><ref name="pmid17074812">{{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }}</ref>


== Interactions ==
== Interactions ==


KLF13 has been shown to [[Protein-protein interaction|interact]] with [[CREB-binding protein]],<ref name=pmid11748222>{{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G |authorlink5=George Stamatoyannopoulos | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 }}</ref> [[Heat shock protein 47]]<ref name=pmid11748222/> and [[PCAF]].<ref name=pmid11748222/>
KLF13 has been shown to [[Protein-protein interaction|interact]] with [[CREB-binding protein]],<ref name=pmid11748222>{{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G |author-link5=George Stamatoyannopoulos | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 |doi-access=free }}</ref> [[Heat shock protein 47]]<ref name=pmid11748222/> and [[PCAF]].<ref name=pmid11748222/>


== See also ==
== See also ==
Line 22: Line 23:
== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x }}
* {{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x | bibcode = 1999NYASA.880...94C | s2cid = 7618847 | doi-access = free }}
* {{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 }}
* {{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 | doi-access = free }}
* {{cite journal | vauthors = Asano H, Li XS, Stamatoyannopoulos G | title = FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes | journal = Blood | volume = 95 | issue = 11 | pages = 3578–84 | date = Jun 2000 | pmid = 10828046 | doi = }}
* {{cite journal | vauthors = Asano H, Li XS, Stamatoyannopoulos G | title = FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes | journal = Blood | volume = 95 | issue = 11 | pages = 3578–84 | date = Jun 2000 | pmid = 10828046 | doi = 10.1182/blood.V95.11.3578}}
* {{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }}
* {{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }}
* {{cite journal | vauthors = Kaczynski J, Zhang JS, Ellenrieder V, Conley A, Duenes T, Kester H, van Der Burg B, Urrutia R | title = The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 39 | pages = 36749–56 | date = Sep 2001 | pmid = 11477107 | doi = 10.1074/jbc.M105831200 }}
* {{cite journal | vauthors = Kaczynski J, Zhang JS, Ellenrieder V, Conley A, Duenes T, Kester H, van Der Burg B, Urrutia R | title = The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 39 | pages = 36749–56 | date = Sep 2001 | pmid = 11477107 | doi = 10.1074/jbc.M105831200 | doi-access = free }}
* {{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 }}
* {{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 | doi-access = free }}
* {{cite journal | vauthors = Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, Urrutia R | title = Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter | journal = The Biochemical Journal | volume = 366 | issue = Pt 3 | pages = 873–82 | date = Sep 2002 | pmid = 12036432 | pmc = 1222816 | doi = 10.1042/BJ20020388 }}
* {{cite journal | vauthors = Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, Urrutia R | title = Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter | journal = The Biochemical Journal | volume = 366 | issue = Pt 3 | pages = 873–82 | date = Sep 2002 | pmid = 12036432 | pmc = 1222816 | doi = 10.1042/BJ20020388 }}
* {{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 }}
* {{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 | doi-access = free }}
* {{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }}
* {{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }}
* {{cite journal | vauthors = Mitsuma A, Asano H, Kinoshita T, Murate T, Saito H, Stamatoyannopoulos G, Naoe T | title = Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells | journal = Biochimica et Biophysica Acta | volume = 1727 | issue = 2 | pages = 125–33 | date = Feb 2005 | pmid = 15716005 | pmc = 2808416 | doi = 10.1016/j.bbaexp.2004.12.007 }}
* {{cite journal | vauthors = Mitsuma A, Asano H, Kinoshita T, Murate T, Saito H, Stamatoyannopoulos G, Naoe T | title = Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1727 | issue = 2 | pages = 125–33 | date = Feb 2005 | pmid = 15716005 | pmc = 2808416 | doi = 10.1016/j.bbaexp.2004.12.007 }}
* {{cite journal | vauthors = Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA | title = A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element | journal = Blood Cells, Molecules & Diseases | volume = 35 | issue = 2 | pages = 227–35 | year = 2006 | pmid = 16023392 | doi = 10.1016/j.bcmd.2005.04.009 }}
* {{cite journal | vauthors = Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA | title = A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element | journal = Blood Cells, Molecules & Diseases | volume = 35 | issue = 2 | pages = 227–35 | year = 2006 | pmid = 16023392 | doi = 10.1016/j.bcmd.2005.04.009 }}
* {{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }}
* {{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }}

Latest revision as of 19:37, 5 September 2024

KLF13
Identifiers
AliasesKLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13
External IDsOMIM: 605328; MGI: 1354948; HomoloGene: 32288; GeneCards: KLF13; OMA:KLF13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

51621

50794

Ensembl

ENSG00000169926
ENSG00000275746

ENSMUSG00000052040

UniProt

Q9Y2Y9

Q9JJZ6

RefSeq (mRNA)

NM_001302461
NM_015995

NM_021366

RefSeq (protein)

NP_001289390
NP_057079

NP_067341

Location (UCSC)Chr 15: 31.33 – 31.44 MbChr 7: 63.54 – 63.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[5][6][7]

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[8] Ghrelin levels also positively correlated with methylation levels of cg07814318.[8] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[8]

Function

[edit]

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[5][9]

KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[7] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[7][10][11][12][13][14][15]

Interactions

[edit]

KLF13 has been shown to interact with CREB-binding protein,[16] Heat shock protein 47[16] and PCAF.[16]

See also

[edit]

References

[edit]
  1. ^ a b c ENSG00000275746 GRCh38: Ensembl release 89: ENSG00000169926, ENSG00000275746 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052040 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KLF13 Kruppel-like factor 13".
  6. ^ Cook T, Gebelein B, Urrutia R (Jun 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences. 880 (1 CELL AND MOLE): 94–102. Bibcode:1999NYASA.880...94C. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854. S2CID 7618847.
  7. ^ a b c Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity. 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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