Glomerulopathy: Difference between revisions
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'''Glomerulopathy''' is a disease that impacts the glomeruli in the [[nephron]], either inflammatory or noninflammatory.<ref name="monarchinitiative.org k902">{{cite web | title=Monarch Initiative | website=monarchinitiative.org |url=https://monarchinitiative.org/HP:0100820 | access-date=January 7, 2024}}</ref> Glomerulopathy includes [[collapsing glomerulopathy]], [[glomerulocystic kidney disease]], glomerulomegaly, [[membranous nephropathy]], and tip lesion glomerulopathy.<ref name="NCBI 2023 v310">{{cite web | title=Glomerulopathy (Concept Id: C0268731) | website=NCBI | date=October 31, 2023 |url=https://www.ncbi.nlm.nih.gov/medgen/451033 | access-date=January 7, 2024}}</ref> |
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'''Glomerulopathy''' is a set of diseases affecting the [[glomeruli]] of the [[nephron]].<ref>{{DorlandsDict|four/000045119|glomerulopathy}}</ref> |
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[[Collapsing glomerulopathy]] (CG) is a clinicopathologic entity that involves [[hypertrophy]] and [[hyperplasia]] of [[Podocyte|podocytes]] and segmentar or global collapse of the [[Glomerulus (kidney)|glomerulus]].<ref name="Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium">{{cite journal | last1=Cutrim | first1=Érico Murilo Monteiro | last2=Neves | first2=Precil Diego Miranda de Meneses | last3=Campos | first3=Marcos Adriano Garcia | last4=Wanderley | first4=Davi Campos | last5=Teixeira-Júnior | first5=Antonio Augusto Lima | last6=Muniz | first6=Monique Pereira Rêgo | last7=Ladchumananandasivam | first7=Francisco Rasiah | last8=Gomes | first8=Orlando Vieira | last9=Vasco | first9=Rafael Fernandes Vanderlei | last10=Brito | first10=Dyego José de Araújo | last11=Lages | first11=Joyce Santos | last12=Salgado-Filho | first12=Natalino | last13=Guedes | first13=Felipe Leite | last14=de Almeida | first14=José Bruno | last15=Magalhães | first15=Marcelo | last16=Araújo | first16=Stanley de Almeida | last17=Silva | first17=Gyl Eanes Barros | title=Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium | journal=Frontiers in Medicine | publisher=Frontiers Media SA | volume=9 | date=March 3, 2022 | issn=2296-858X | doi=10.3389/fmed.2022.846173 | doi-access=free | page=| pmid=35308512 | pmc=8927620 }}</ref> |
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Such diseases can include processes that are inflammatory or noninflammatory. Because the term ''glomerulitis'' exists for inflammatory conditions,<ref>{{DorlandsDict|four/000045095|glomerulitis}}</ref> ''glomerulopathy'' sometimes carries a noninflammatory implication. |
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[[Glomerulocystic kidney disease]] is a rare form of [[renal cyst]] disease. Cortical microcysts, which are portrayed by cystic dilatation of [[Bowman's capsule|Bowman's spaces]], are its defining feature.<ref name="Glomerulocystic disease">{{cite journal | last1=Sahay | first1=M. | last2=Gowrishankar | first2=S. | title=Glomerulocystic disease | journal=Clinical Kidney Journal | publisher=Oxford University Press (OUP) | volume=3 | issue=4 | date=April 13, 2010 | issn=2048-8505 | doi=10.1093/ndtplus/sfq048 | pages=349–350 | doi-access=free| pmid=25949428 }}</ref> |
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Glomerulomegaly is defined by unusually large [[Glomerulus (kidney)|glomeruli]].<ref name="Towards a definition of glomerulomegaly">{{cite journal | last1=Hughson | first1=M. D. | last2=Hoy | first2=W. E. | last3=Douglas-Denton | first3=R. N. | last4=Zimanyi | first4=M. A. | last5=Bertram | first5=J. F. | title=Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations | journal=Nephrology Dialysis Transplantation | publisher=Oxford University Press (OUP) | volume=26 | issue=7 | date=November 29, 2010 | issn=0931-0509 | doi=10.1093/ndt/gfq688 | pages=2202–2208 | doi-access=free| pmid=21115671 | pmc=3164445 }}</ref> |
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[[Membranous nephropathy]] (MN) is an uncommon [[Autoimmune disease|autoimmune condition]] in which [[Autoantibody|autoantibodies]] directed primarily against [[podocyte]] antigens target the [[Glomerulus (kidney)|glomerulus]], causing electron-dense [[Immune complex|immune complexes]] to form, complement activation to occur, and severe [[proteinuria]].<ref name="Advances in Membranous Nephropathy">{{cite journal | last1=Ronco | first1=Pierre | last2=Plaisier | first2=Emmanuelle | last3=Debiec | first3=Hanna | title=Advances in Membranous Nephropathy | journal=Journal of Clinical Medicine | publisher=MDPI AG | volume=10 | issue=4 | date=February 5, 2021 | issn=2077-0383 | doi=10.3390/jcm10040607 | doi-access=free | page=607}}</ref> |
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The glomerular tip lesion (GTL) is a unique histopathologic lesion that appears in idiopathic [[nephrotic syndrome]] patients.<ref name="Glomerular tip lesion: A distinct entity">{{cite journal | last1=Stokes | first1=M. Barry | last2=Markowitz | first2=Glen S. | last3=Lin | first3=Julie | last4=Valeri | first4=Anthony M. | last5=D'Agati | first5=Vivette D. | title=Glomerular tip lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum | journal=Kidney International | publisher=Elsevier BV | volume=65 | issue=5 | year=2004 | issn=0085-2538 | doi=10.1111/j.1523-1755.2004.00563.x | pages=1690–1702| pmid=15086908 | doi-access=free }}</ref> |
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==See also== |
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* [[Glomerulonephritis]] |
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* [[Glomerulonephrosis]] |
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==References== |
==References== |
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{{reflist}} |
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==Further reading== |
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* {{cite journal | last=Couser | first=William G. | title=Primary Membranous Nephropathy | journal=Clinical Journal of the American Society of Nephrology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=12 | issue=6 | date=May 26, 2017 | issn=1555-9041 | doi=10.2215/cjn.11761116 | pages=983–997 | ref=none | doi-access=free| pmid=28550082 | pmc=5460716 }} |
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* {{cite journal | last1=Ronco | first1=Pierre | last2=Beck | first2=Laurence | last3=Debiec | first3=Hanna | last4=Fervenza | first4=Fernando C. | last5=Hou | first5=Fan Fan | last6=Jha | first6=Vivekanand | last7=Sethi | first7=Sanjeev | last8=Tong | first8=Allison | last9=Vivarelli | first9=Marina | last10=Wetzels | first10=Jack | title=Membranous nephropathy | journal=Nature Reviews Disease Primers | publisher=Springer Science and Business Media LLC | volume=7 | issue=1 | date=September 30, 2021 | issn=2056-676X | doi=10.1038/s41572-021-00303-z | pmid=34593809 | ref=none}} |
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{{Nephrology}} |
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{{Glomerular disease}} |
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Latest revision as of 21:25, 14 September 2024
| Glomerulopathy | |
|---|---|
| Specialty | Urology  |
Glomerulopathy is a disease that impacts the glomeruli in the nephron, either inflammatory or noninflammatory.[1] Glomerulopathy includes collapsing glomerulopathy, glomerulocystic kidney disease, glomerulomegaly, membranous nephropathy, and tip lesion glomerulopathy.[2]
Collapsing glomerulopathy (CG) is a clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus.[3]
Glomerulocystic kidney disease is a rare form of renal cyst disease. Cortical microcysts, which are portrayed by cystic dilatation of Bowman's spaces, are its defining feature.[4]
Glomerulomegaly is defined by unusually large glomeruli.[5]
Membranous nephropathy (MN) is an uncommon autoimmune condition in which autoantibodies directed primarily against podocyte antigens target the glomerulus, causing electron-dense immune complexes to form, complement activation to occur, and severe proteinuria.[6]
The glomerular tip lesion (GTL) is a unique histopathologic lesion that appears in idiopathic nephrotic syndrome patients.[7]
See also
[edit]References
[edit]- ^ "Monarch Initiative". monarchinitiative.org. Retrieved January 7, 2024.
- ^ "Glomerulopathy (Concept Id: C0268731)". NCBI. October 31, 2023. Retrieved January 7, 2024.
- ^ Cutrim, Érico Murilo Monteiro; Neves, Precil Diego Miranda de Meneses; Campos, Marcos Adriano Garcia; Wanderley, Davi Campos; Teixeira-Júnior, Antonio Augusto Lima; Muniz, Monique Pereira Rêgo; Ladchumananandasivam, Francisco Rasiah; Gomes, Orlando Vieira; Vasco, Rafael Fernandes Vanderlei; Brito, Dyego José de Araújo; Lages, Joyce Santos; Salgado-Filho, Natalino; Guedes, Felipe Leite; de Almeida, José Bruno; Magalhães, Marcelo; Araújo, Stanley de Almeida; Silva, Gyl Eanes Barros (March 3, 2022). "Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium". Frontiers in Medicine. 9. Frontiers Media SA. doi:10.3389/fmed.2022.846173. ISSN 2296-858X. PMC 8927620. PMID 35308512.
- ^ Sahay, M.; Gowrishankar, S. (April 13, 2010). "Glomerulocystic disease". Clinical Kidney Journal. 3 (4). Oxford University Press (OUP): 349–350. doi:10.1093/ndtplus/sfq048. ISSN 2048-8505. PMID 25949428.
- ^ Hughson, M. D.; Hoy, W. E.; Douglas-Denton, R. N.; Zimanyi, M. A.; Bertram, J. F. (November 29, 2010). "Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations". Nephrology Dialysis Transplantation. 26 (7). Oxford University Press (OUP): 2202–2208. doi:10.1093/ndt/gfq688. ISSN 0931-0509. PMC 3164445. PMID 21115671.
- ^ Ronco, Pierre; Plaisier, Emmanuelle; Debiec, Hanna (February 5, 2021). "Advances in Membranous Nephropathy". Journal of Clinical Medicine. 10 (4). MDPI AG: 607. doi:10.3390/jcm10040607. ISSN 2077-0383.
- ^ Stokes, M. Barry; Markowitz, Glen S.; Lin, Julie; Valeri, Anthony M.; D'Agati, Vivette D. (2004). "Glomerular tip lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum". Kidney International. 65 (5). Elsevier BV: 1690–1702. doi:10.1111/j.1523-1755.2004.00563.x. ISSN 0085-2538. PMID 15086908.
Further reading
[edit]- Couser, William G. (May 26, 2017). "Primary Membranous Nephropathy". Clinical Journal of the American Society of Nephrology. 12 (6). Ovid Technologies (Wolters Kluwer Health): 983–997. doi:10.2215/cjn.11761116. ISSN 1555-9041. PMC 5460716. PMID 28550082.
- Ronco, Pierre; Beck, Laurence; Debiec, Hanna; Fervenza, Fernando C.; Hou, Fan Fan; Jha, Vivekanand; Sethi, Sanjeev; Tong, Allison; Vivarelli, Marina; Wetzels, Jack (September 30, 2021). "Membranous nephropathy". Nature Reviews Disease Primers. 7 (1). Springer Science and Business Media LLC. doi:10.1038/s41572-021-00303-z. ISSN 2056-676X. PMID 34593809.