Homotaurine: Difference between revisions
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Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: ChemSpiderID InChI1 InChIKey1 SMILES. |
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|OtherNames=Tramiprosat; Alzhemed; 3aps |
|OtherNames=Tramiprosat; Alzhemed; 3aps |
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|Section1= {{Chembox Identifiers |
|Section1= {{Chembox Identifiers |
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| ChemSpiderID = 1584 |
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| InChI1 = 1/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7) |
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| InChIKey1 = SNKZJIOFVMKAOJ-UHFFFAOYAT |
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| PubChem=1646 |
| PubChem=1646 |
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| SMILES= |
| SMILES = O=S(=O)(O)CCCN |
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}} |
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|Section2= {{Chembox Properties |
|Section2= {{Chembox Properties |
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| C=3|H=9|N=1|O=3|S=1 |
| C=3|H=9|N=1|O=3|S=1 |
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Revision as of 19:04, 30 October 2010
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| Names | |
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| IUPAC name
3-Aminopropane-1-sulfonic acid
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| Other names
Tramiprosat; Alzhemed; 3aps
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.020.889 |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C3H9NO3S | |
| Molar mass | 139.17 g·mol−1 |
| Melting point | 293 °C (decomposition) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Homotaurine (also spelled homotaurin) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant.[2]
Homotaurine is also being investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain.[3]
Homotaurine is a zwitterion at neutral pH.
References
- ^ Homotaurine at Sigma-Aldrich
- ^ Fariello RG, Golden GT, Pisa M (1982). "Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid". Neurology. 32 (3): 241–5. PMID 7199633.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Aisen PS, Gauthier S, Vellas B; et al. (2007). "Alzhemed: a potential treatment for Alzheimer's disease". Curr Alzheimer Res. 4 (4): 473–8. doi:10.2174/156720507781788882. PMID 17908052.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)