Naltriben: Difference between revisions

Naltriben
Clinical data
ATC code	none;
Identifiers
CAS Number	111555-58-9;
PubChem CID	5486827;
IUPHAR/BPS	1640;
ChemSpider	4589081 ;
ChEMBL	ChEMBL100940 ;
CompTox Dashboard (EPA)	DTXSID80912218 ;
Chemical and physical data
Formula	C26H25NO4
Molar mass	415.480 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7;
	InChI InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 ; Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N ;
	(verify)

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Revision as of 17:53, 22 May 2017

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ₁ and δ₂ subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.^[1] It also acts as a κ-opioid agonist at high doses.^[2]

References

^ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
^ Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443

[1] Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833

[2] Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443

[1]

[2]

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-'''Naltriben''' is a potent and selective [[competitive antagonist|antagonist]] for the [[delta opioid receptor]], which is used in scientific research. It has similar effects to the more widely used δ antagonist [[naltrindole]], but with different binding affinity for the δ<sub>1</sub> and δ<sub>2</sub> subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.<ref>Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. ''Journal of Pharmacology and Experimental Therapeutics''. 1991 May;257(2):676-80. PMID 1851833</ref> It also acts as a [[kappa opioid receptor|κ-opioid]] agonist at high doses.<ref>Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. ''Life Sciences''. 1994;55(4):PL79-84. PMID 8028443</ref>
+'''Naltriben''' is a potent and selective [[competitive antagonist|antagonist]] for the [[delta opioid receptor]], which is used in scientific research. It has similar effects to the more widely used δ antagonist [[naltrindole]], but with different binding affinity for the δ<sub>1</sub> and δ<sub>2</sub> subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.<ref>Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. ''Journal of Pharmacology and Experimental Therapeutics''. 1991 May;257(2):676-80. {{PMID|1851833}}</ref> It also acts as a [[kappa opioid receptor|κ-opioid]] agonist at high doses.<ref>Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. ''Life Sciences''. 1994;55(4):PL79-84. {{PMID|8028443}}</ref>
 ==See also==