Trioxsalen

Trioxsalen

Names
IUPAC name 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
Identifiers
CAS Number	3902-71-4
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1475 Y
ChemSpider	5383 Y
ECHA InfoCard	100.021.327
PubChem CID	5585
CompTox Dashboard (EPA)	DTXSID3023716
InChI InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 Y Key: FMHHVULEAZTJMA-UHFFFAOYSA-N Y InChI=1/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 Key: FMHHVULEAZTJMA-UHFFFAOYAF
SMILES O=C/3Oc2c(c1oc(cc1cc2\C(=C\3)C)C)C
Properties
Chemical formula	C14H12O3
Molar mass	228.24328
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage. The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.