Medial forebrain bundle: Difference between revisions
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The '''medial forebrain bundle''' ('''MFB'''), is a complex bundle of axons coming from the basal [[olfactory]] regions, the [[periamygdaloid]] region, and the [[septal nuclei]]. |
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==Anatomy== |
==Anatomy== |
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The MFB passes through the lateral [[hypothalamus]], with some carrying on into the [[tegmentum]]. It contains both ascending and descending fibers. It also represents a part of the [[mesolimbic pathway]], carrying information between the [[ventral tegmentum]] and the [[nucleus accumbens]]. |
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==Function== |
==Function== |
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It is commonly accepted that the MFB is a part of the [[reward system]], involved in the integration of reward and pleasure.<ref name="pmid16893295">{{cite journal |author=Hernandez G, Hamdani S, Rajabi H, ''et al.'' |title=Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences |journal=Behav. Neurosci. |volume=120 |issue=4 |pages=888–904 |year=2006 |month=August |pmid=16893295 |doi=10.1037/0735-7044.120.4.888 |url=http://content.apa.org/journals/bne/120/4/888}}</ref> |
It is commonly accepted that the MFB is a part of the [[reward system]], involved in the integration of reward and pleasure.<ref name="pmid16893295">{{cite journal |author=Hernandez G, Hamdani S, Rajabi H, ''et al.'' |title=Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences |journal=Behav. Neurosci. |volume=120 |issue=4 |pages=888–904 |year=2006 |month=August |pmid=16893295 |doi=10.1037/0735-7044.120.4.888 |url=http://content.apa.org/journals/bne/120/4/888}}</ref> |
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Electrical stimulation of the medial forebrain bundle is believed to cause [[pleasure center|sensations of pleasure]]. This hypothesis is based upon [[intracranial self-stimulation]] (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable.<ref>http://www.salon.com/2013/03/23/science_fiction_turns_real_genetically_engineering_animals_for_war/</ref> This is most likely because the medial forebrain bundle carries information from the [[ventral tegmental area]] (VTA) to the [[nucleus accumbens]] ( |
Electrical stimulation of the medial forebrain bundle is believed to cause [[pleasure center|sensations of pleasure]]. This hypothesis is based upon [[intracranial self-stimulation]] (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable.<ref>http://www.salon.com/2013/03/23/science_fiction_turns_real_genetically_engineering_animals_for_war/</ref> This is most likely because the medial forebrain bundle carries information from the [[ventral tegmental area]] (VTA) to the [[nucleus accumbens]] (NAc or Acb). The nAcc is a recognized reward center, and activation of the pathway from the VTA to the NAc is believed to be rewarding, which is why it is sometimes referred to as the '''hedonic highway'''.<ref>''The Owner's Manual for the Brain: Everyday Applications from Mind-Brain Research'', 3rd ed. 2006. Austin: Bard Press. ISBN 1-885167-64-4</ref> |
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==References== |
==References== |
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Revision as of 01:26, 11 December 2013
| Medial forebrain bundle | |
|---|---|
| Details | |
| Identifiers | |
| Latin | fasciculus medialis telencephali |
| MeSH | D008474 |
| NeuroNames | 433 |
| NeuroLex ID | birnlex_908 |
| TA98 | A14.1.08.955 |
| TA2 | 5764 |
| FMA | 62064 |
| Anatomical terms of neuroanatomy | |
The medial forebrain bundle (MFB), is a complex bundle of axons coming from the basal olfactory regions, the periamygdaloid region, and the septal nuclei.
Anatomy
The MFB passes through the lateral hypothalamus, with some carrying on into the tegmentum. It contains both ascending and descending fibers. It also represents a part of the mesolimbic pathway, carrying information between the ventral tegmentum and the nucleus accumbens.
Function
It is commonly accepted that the MFB is a part of the reward system, involved in the integration of reward and pleasure.[1]
Electrical stimulation of the medial forebrain bundle is believed to cause sensations of pleasure. This hypothesis is based upon intracranial self-stimulation (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable.[2] This is most likely because the medial forebrain bundle carries information from the ventral tegmental area (VTA) to the nucleus accumbens (NAc or Acb). The nAcc is a recognized reward center, and activation of the pathway from the VTA to the NAc is believed to be rewarding, which is why it is sometimes referred to as the hedonic highway.[3]
References
- ^ Hernandez G, Hamdani S, Rajabi H; et al. (2006). "Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences". Behav. Neurosci. 120 (4): 888–904. doi:10.1037/0735-7044.120.4.888. PMID 16893295.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ http://www.salon.com/2013/03/23/science_fiction_turns_real_genetically_engineering_animals_for_war/
- ^ The Owner's Manual for the Brain: Everyday Applications from Mind-Brain Research, 3rd ed. 2006. Austin: Bard Press. ISBN 1-885167-64-4
External links
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