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Naltriben

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This is an old revision of this page, as edited by DePiep (talk | contribs) at 18:18, 2 April 2016 (Remove redundant parameters InChI, InChIKey (StdInChI, StdInChIKey are used). See Talk (via AWB script)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Naltriben
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H25NO4
Molar mass415.480 g/mol g·mol−1
3D model (JSmol)
  • Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7
  • InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 checkY
  • Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N checkY
  (verify)

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]

See also

References

  1. ^ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
  2. ^ Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443


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