Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Technetium (99mTc) nofetumomab merpentan: Difference between pages

Content deleted Content added

VisualWikitext

@@ Line 1: / Line 1: @@
+{{Short description|Mouse monoclonal antibody}}
-{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:Technetium_(99mTc)_nofetumomab_merpentan|oldid=460517186}} 460517186] of page [[Technetium_(99mTc)_nofetumomab_merpentan]] with values updated to verified values.}}
+{{DISPLAYTITLE:Technetium (<sup>99m</sup>Tc) nofetumomab merpentan}}
 {{Drugbox
 | Verifiedfields = changed
-| verifiedrevid = 450331595
+| verifiedrevid = 470478313
 | image = Technetium-99m nofetumomab merpentan skeletal.svg
 | drug_name = Technetium (<sup>99m</sup>Tc) nofetumomab merpentan
+<!-- Monoclonal antibody data -->
-<!--Monoclonal antibody data-->
 | type = mab
 | mab_type = Fab
 | source = o
 | target =
+<!-- Clinical data -->
+| tradename = Verluma
-<!--Clinical data-->
-| tradename =
 | pregnancy_AU =
 | pregnancy_US =
@@ Line 23: / Line 22: @@
 | legal_status =
 | routes_of_administration =
+<!-- Pharmacokinetic data -->
-<!--Pharmacokinetic data-->
 | bioavailability =
 | protein_bound =
@@ Line 30: / Line 28: @@
 | elimination_half-life = 10.5 hours
 | excretion = [[Kidney|renal]] (64%)
+<!-- Identifiers -->
-<!--Identifiers-->
 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
-| ChemSpiderID = NA
+| ChemSpiderID = none
-| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number_Ref = {{cascite|changed|??}}
-| CAS_number = <!-- blanked - oldvalue: 165942-79-0 -->
+| CAS_number = 165942-79-0
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 9UFH75HT7S
 | ATC_prefix = none
 | ATC_suffix =
@@ Line 41: / Line 40: @@
 | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
 | DrugBank =
+<!-- Chemical data -->
-<!--Chemical data-->
 | chemical_formula =
 | molecular_weight =
 }}
+'''Technetium (<sup>99m</sup>Tc) nofetumomab merpentan''' (trade name '''Verluma''') is a [[mouse]] [[monoclonal antibody]] derivative used in the diagnosis of [[lung cancer]],<ref>{{cite journal | vauthors = Straka MR, Joyce JM, Myers DT | title = Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer | journal = Clinical Nuclear Medicine | volume = 25 | issue = 1 | pages = 54–5 | date = January 2000 | pmid = 10634533 | doi = 10.1097/00003072-200001000-00013 }}</ref> [[gastrointestinal cancer|gastrointestinal]], [[breast cancer|breast]], [[ovarian cancer|ovary]], [[pancreas cancer|pancreas]], [[kidney cancer|kidney]], [[cervix cancer|cervix]], and [[bladder carcinoma]].<ref>{{cite journal | vauthors = Breitz HB, Tyler A, Bjorn MJ, Lesley T, Weiden PL | title = Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy | journal = Clinical Nuclear Medicine | volume = 22 | issue = 9 | pages = 615–20 | date = September 1997 | pmid = 9298295 | doi = 10.1097/00003072-199709000-00007 }}</ref> The antibody part, [[nofetumomab]], is attached to the [[chelator]] [[merpentan]], which [[isotopic labeling|links]] it to the [[radioisotope]] [[technetium-99m]] (<sup>99m</sup>Tc).<ref>{{cite web | title = International Nonproprietary Names (INN) for pharmaceutical substances | url = http://apps.who.int/medicinedocs/pdf/s4894e/s4894e.pdf | archive-url = https://web.archive.org/web/20110703193226/http://apps.who.int/medicinedocs/pdf/s4894e/s4894e.pdf | url-status = dead | archive-date = July 3, 2011 | date = 2002 | publisher = World Health Organization | location = Geneva }}</ref>
+==Nofetumomab==
+Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen [[EpCAM]].<ref>{{cite book | vauthors = Tsurushita N, Vasquez M | chapter = Humanization of monoclonal antibodies | veditors = Reth M, Radbruch A, Alt F, Honjo T, Neuberger M | title = Molecular Biology of B Cells | date = January 2004 | pages = 533–545 | publisher = Academic Press | chapter-url = https://books.google.com/books?id=fF8d3eZ6SZ8C&pg=PA533 | isbn = 978-0-08-047950-7 }}</ref> and/or [[CD20]]/[[MS4A1]]<ref>{{cite web | url = http://www.creativebiolabs.net/Anti-MS4A1-Therapeutic-Antibody-VERLUMA-13782.htm | title = Anti-MS4A1 Therapeutic Antibody (Technetium (99MTC) Nofetumomab Merpentan) | publisher =  Creative BioLabs }}</ref>
+It is the [[Fragment antigen-binding|Fab]] part of murine MAb [[NR-LU-10]].<ref name=MARTK/>
+==Merpentan==
+The chelator part : merpentan is a [[phenthioate]] ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.<ref name=MARTK>{{cite web | first = Efrain | last = Mudd | name-list-style = vanc | date = 27 February 2015 | url = http://www.pharmacologicalsciences.us/pharmaceutical-chemistry/monoclonal-antibody-radionuclide-test-kits.html | title = Monoclonal Antibody Radionuclide Test Kits | publisher = Pharmacological Sciences }}</ref>
+===Phenthioate===
+Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate<ref>{{cite patent | country = US | number = 3934010 | title = Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters | inventor = Drabek J, Varsanyi D | assign1 = Ciba Geigy Corporation | gdate = 20 January 1976 }}</ref>
+== References ==
+{{reflist}}
+{{Monoclonals for tumors}}
+{{DEFAULTSORT:Technetium (99mtc) Nofetumomab Merpentan}}
+[[Category:Technetium compounds]]
+[[Category:Technetium-99m]]
+[[Category:Monoclonal antibodies for tumors]]
+[[Category:Antibody-drug conjugates]]
+[[Category:Radiopharmaceuticals]]
+{{monoclonal-antibody-stub}}
+{{antineoplastic-drug-stub}}