C1QTNF1

C1QTNF1
Identifiers
Aliases	C1QTNF1, CTRP1, GIP, ZSIG37, C1q and tumor necrosis factor related protein 1, C1q and TNF related 1
External IDs	OMIM: 610365; MGI: 1919254; HomoloGene: 10548; GeneCards: C1QTNF1; OMA:C1QTNF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,049,788 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,340,789 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; right auricle; ; Descending thoracic aorta; ; ascending aorta; ; right lobe of thyroid gland; ; apex of heart; ; left lobe of thyroid gland;
	Top expressed in
	decidua; ; gastrula; ; lumbar spinal ganglion; ; lip; ; esophagus; ; calvaria; ; ankle; ; ascending aorta; ; semi-lunar valve; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; collagen binding;
Cellular component	extracellular region; collagen; integral component of plasma membrane; extracellular space;
Biological process	positive regulation of cytosolic calcium ion concentration; negative regulation of platelet activation; protein heterotrimerization; regulation of glucose metabolic process; positive regulation of gene expression; positive regulation of protein kinase B signaling; positive regulation of aldosterone secretion; protein homooligomerization; negative regulation of platelet aggregation; positive regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	114897
	56745
	ENSG00000173918
	ENSMUSG00000017446
	Q9BXJ1
	Q9QXP7
	NM_030968; NM_153372; NM_198593; NM_198594
	NM_001204129; NM_001204130; NM_019959
	NP_112230; NP_699203; NP_940995; NP_940996
	NP_001191058; NP_001191059; NP_064343
	Wikidata
View/Edit Human	View/Edit Mouse

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Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene.^[5]^[6]

Interactions

C1QTNF1 has been shown to interact with Arginine vasopressin receptor 2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173918 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017446 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.
^ "Entrez Gene: C1QTNF1 C1q and tumor necrosis factor related protein 1".
^ Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.

External links

Human C1QTNF1 genome location and C1QTNF1 gene details page in the UCSC Genome Browser.
Human GIP genome location and GIP gene details page in the UCSC Genome Browser.

Innamorati G, Bianchi E, Whang MI (June 2006). "An intracellular role for the C1q-globular domain". Cellular Signalling. 18 (6): 761–70. doi:10.1016/j.cellsig.2005.11.004. PMID 16386877.
Kim KY, Kim HY, Kim JH, Lee CH, Kim DH, Lee YH, Han SH, Lim JS, Cho DH, Lee MS, Yoon S, Kim KI, Yoon DY, Yang Y (July 2006). "Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue". FEBS Letters. 580 (16): 3953–60. doi:10.1016/j.febslet.2006.06.034. PMID 16806199. S2CID 84691242.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173918 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017446 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12409230-5] Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.

[entrez-6] "Entrez Gene: C1QTNF1 C1q and tumor necrosis factor related protein 1".

[autogenerated1-7] Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.

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[2]

[3]

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[5]

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[7]

Interactions

References

External links

Further reading