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E-6801

From Wikipedia, the free encyclopedia
E-6801
Names
Preferred IUPAC name
6-Chloro-N-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}imidazo[2,1-b][1,3]thiazole-5-sulfonamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C17H18ClN5O2S2/c1-22(2)6-5-11-10-19-14-4-3-12(9-13(11)14)21-27(24,25)16-15(18)20-17-23(16)7-8-26-17/h3-4,7-10,19,21H,5-6H2,1-2H3
    Key: RZAXUKVIIWUIOM-UHFFFAOYSA-N
  • CN(C)CCC1=CNC2=C1C=C(C=C2)NS(=O)(=O)C3=C(N=C4N3C=CS4)Cl
Properties
C17H18ClN5O2S2
Molar mass 423.94 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

E-6801 is a partial agonist of the 5-HT6 receptor.[1] It enhanced recognition memory and reversed the memory deficits of scopolamine in an object recognition task in a rat model.[2] The mechanism of memory enhancement is due to a combined modulation of cholinergic and glutamatergic neurotransmission.

See also

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References

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  1. ^ Romero, G. (August 2006). "Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways". British Journal of Pharmacology. 148 (8): 1133–43. doi:10.1038/sj.bjp.0706827. PMC 1752021. PMID 16865095.
  2. ^ Kendall, I. (February 2011). "E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat". Psychopharmacology. 213 (2–3): 413–30. doi:10.1007/s00213-010-1854-3. PMID 20405281. S2CID 10116984.
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