Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abundant in mammary epithelium than in lymphocytes. In human breast tissue specimens, we identified BLV DNA by using nested liquid-phase PCR and DNA sequencing. Variations from the bovine reference sequence were infrequent and limited to base substitutions. In situ PCR and immunohistochemical testing localized BLV to the secretory epithelium of the breast. Our finding of BLV in human tissues indicates a risk for the acquisition and proliferation of this virus in humans. Further research is needed to determine whether BLV may play a direct role in human disease.

Objectives

To evaluate the accuracy of three-dimensional stereophotogrammetry by comparing values obtained from direct anthropometry and the 3dMDface system. To achieve a more comprehensive evaluation of the reliability of 3dMD, both linear and surface measurements were examined.

Setting and sample population

UCLA Section of Orthodontics. Mannequin head as model for anthropometric measurements.

Material and methods

Image acquisition and analysis were carried out on a mannequin head using 16 anthropometric landmarks and 21 measured parameters for linear and surface distances. 3D images using 3dMDface system were made at 0, 1 and 24 hours; 1, 2, 3 and 4 weeks. Error magnitude statistics used include mean absolute difference, standard deviation of error, relative error magnitude and root mean square error. Intra-observer agreement for all measurements was attained.

Results

Overall mean errors were lower than 1.00 mm for both linear and surface parameter measurements, except in 5 of the 21 measurements. The three longest parameter distances showed increased variation compared to shorter distances. No systematic errors were observed for all performed paired t tests (P<.05). Agreement values between two observers ranged from 0.91 to 0.99.

Conclusions

Measurements on a mannequin confirmed the accuracy of all landmarks and parameters analysed in this study using the 3dMDface system. Results indicated that 3dMDface system is an accurate tool for linear and surface measurements, with potentially broad-reaching applications in orthodontics, surgical treatment planning and treatment evaluation.

The superconducting transition temperature (T_C) in a FeSe monolayer on SrTiO₃ is enhanced up to 100 K (refs ,,,). High T_C is also found in bulk iron chalcogenides with similar electronic structure to that of monolayer FeSe, which suggests that higher T_C may be achieved through electron doping, pushing the Fermi surface (FS) topology towards leaving only electron pockets. Such an observation, however, has been limited to chalcogenides, and is in contrast to the iron pnictides, for which the maximum T_C is achieved with both hole and electron pockets forming considerable FS nesting instability. Here, we report angle-resolved photoemission characterization revealing a monotonic increase of T_C from 24 to 41.5 K upon surface doping on optimally doped Ba(Fe_1-xCo_x)₂As₂. The doping changes the overall FS topology towards that of chalcogenides through a rigid downward band shift. Our findings suggest that higher electron doping and concomitant changes in FS topology are favourable conditions for the superconductivity, not only for iron chalcogenides, but also for iron pnictides.

A search for the dinucleon decay pp → K+ K+ has been performed using 91.6  kton·yr data from Super-Kamiokande-I. This decay provides a sensitive probe of the R-parity-violating parameter λ112''. A boosted decision tree analysis found no signal candidates in the data. The expected background was 0.28±0.19 atmospheric neutrino induced events and the estimated signal detection efficiency was 12.6%±3.2%. A lower limit of 1.7×10(32)  years has been placed on the partial lifetime of the decay O16 → C14K+ K+ at 90% C.L. A corresponding upper limit of 7.8×10(-9) has been placed on the parameter λ112''.

We present a measurement of the density of GeV muons in near-vertical air showers using three years of data recorded by the IceTop array at the South Pole. Depending on the shower size, the muon densities have been measured at lateral distances between 200 and 1000 m. From these lateral distributions, we derive the muon densities as functions of energy at reference distances of 600 and 800 m for primary energies between 2.5 and 40 PeV and between 9 and 120 PeV, respectively. The muon densities are determined using, as a baseline, the hadronic interaction model Sibyll 2.1 together with various composition models. The measurements are consistent with the predicted muon densities within these baseline interaction and composition models. The measured muon densities have also been compared to simulations using the post-LHC models EPOS-LHC and QGSJet-II.04. The result of this comparison is that the post-LHC models together with any given composition model yield higher muon densities than observed. This is in contrast to the observations above 1 EeV where all model simulations yield for any mass composition lower muon densities than the measured ones. The post-LHC models in general feature higher muon densities so that the agreement with experimental data at the highest energies is improved but the muon densities are not correct in the energy range between 2.5 and about 100 PeV.

A new event reconstruction algorithm based on a maximum likelihood method has been developed for Super-Kamiokande. Its improved kinematic and particle identification capabilities enable the analysis of atmospheric neutrino data in a detector volume 32% larger than previous analyses and increase the sensitivity to the neutrino mass hierarchy.Analysis of a 253.9 kton•year exposure of the Super-Kamiokande IV atmospheric neutrino data has yielded a weak preference for the normal hierarchy, disfavoring the inverted hierarchy at 74% assuming oscillations at the best fit of the analysis.

Neutral current (NC) interactions of atmospheric neutrinos on oxygen form one of the major backgrounds in the search for supernova relic neutrinos with water-based Cherenkov detectors. The NC channel is dominated by neutrino quasielastic (NCQE) scattering off nucleons inside O16 nuclei. In this paper we report the first measurement of NCQE cross section using atmospheric neutrinos at Super-Kamiokande (SK). The measurement used 2,778 live days of SK-IV data with a fiducial volume of 22.5 kiloton water. Within the visible energy window of 7.5-29.5 MeV, we observed 117 events compared to the expected 71.9 NCQE signal and 53.1 background events. Weighted by the atmospheric neutrino spectrum from 160 MeV to 10 GeV, the flux averaged NCQE cross section is measured to be (1.01±0.17(stat.)-0.30+0.78(sys.))×10-38 cm2.

Supernova detection is a major objective of the Super-Kamiokande (SK) experiment. In the next stage of SK (SK-Gd), gadolinium (Gd) sulfate will be added to the detector, which will improve the ability of the detector to identify neutrons. A core-collapse supernova (CCSN) will be preceded by an increasing flux of neutrinos and antineutrinos, from thermal and weak nuclear processes in the star, over a timescale of hours; some of which may be detected at SK-Gd. This could provide an early warning of an imminent CCSN, hours earlier than the detection of the neutrinos from core collapse. Electron antineutrino detection will rely on inverse beta decay events below the usual analysis energy threshold of SK, so Gd loading is vital to reduce backgrounds while maximizing detection efficiency. Assuming normal neutrino mass ordering, more than 200 events could be detected in the final 12 hr before core collapse for a 15-25 solar mass star at around 200 pc, which is representative of the nearest red supergiant to Earth, α-Ori (Betelgeuse). At a statistical false alarm rate of 1 per century, detection could be up to 10 hr before core collapse, and a pre-supernova star could be detected by SK-Gd up to 600 pc away. A pre-supernova alert could be provided to the astrophysics community following gadolinium loading.