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Scholarly Works (1 results)

Article
Peer Reviewed

Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

Anderson, Mark;
Mohan, JF;
Calderon, B;
Anderson, MS;
Unanue, ER

UC San Francisco Previously Published Works (2013)

In the nonobese diabetic mouse, a predominant component of the autoreactive CD4+ T cell repertoire is directed against the B:9-23 segment of the insulin B chain. Previous studies established that the majority of insulin-reactive T cells specifically recogn