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Article
Peer Reviewed

Association between tumor-infiltrating lymphocytes and survival in patients with metastatic breast cancer receiving first-line chemotherapy: analysis of CALGB 40502.

Stover, Daniel;
Salgado, Roberto;
Savenkov, Oleksander;
Ballman, Karla;
Mayer, Erica;
Magbanua, Mark;
Loi, Sherene;
Vater, Mark;
Glover, Kristyn;
Watson, Mark;
Wen, Yujia;
Symmans, W;
Perou, Charles;
Carey, Lisa;
Partridge, Ann;
Rugo, Hope

UC San Francisco Previously Published Works (2024)

Association of stromal tumor-infiltrating lymphocytes (sTILs) with survival outcomes among patients with metastatic breast cancer (MBC) remains unclear. The primary objective was to evaluate the association of sTILs with progression-free survival in randomized phase III trial CALGB 40502. sTILs were associated with progression-free and overall survival in chemotherapy-treated MBC when controlling for treatment arm; however, this effect did not remain significant after additional adjustment for hormone receptor status. CALGB is now part of the Alliance for Clinical Trials in Oncology. Trial Registration: ClinicalTrials.gov: NCT00785291.

Cover page: Association between tumor-infiltrating lymphocytes and survival in patients with metastatic breast cancer receiving first-line chemotherapy: analysis of CALGB 40502.