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However, the effect of CaMKII on atrial action potential under oxidative stress condition is not completely understood. In this study, we developed a ...
The present study developed a human atrial cell model including effects of oxidative stress by incorporating reactive oxygen species (ROS)-induced CaMKII ...
Jan 7, 2021 · The simulation results showed that oxidative stress increased CaMKII activation, increased ICaL and altered Ca 2+ cycling (Fig. 2). Therefore, ...
CaMKII is known to regulate the chronotropic response to stress and mice with CaMKII inhibition have a smaller increase in heart rate with isoproterenol ...
Role of Oxidation-Dependent CaMKII Activation in the Genesis of ...
pmc.ncbi.nlm.nih.gov › PMC7327560
Jun 20, 2020 · This study showed the effects of excess reactive oxygen species on calcium cycling and action potential in atrial myocytes and provided insights regarding ...
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Dec 18, 2020 · Therefore, we conclude that oxidative stress could significantly disrupt the ion hemostasis under the CaMKII overexpression scenario, during ...
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Nov 2, 2018 · Electrophysiological effects of triggered calcium waves on the action potential in left atrial myocytes from normal and failing dog heart.
Jun 22, 2020 · Simulation results demonstrated that, under oxidative stress conditions, EAD hindered the conduction of electrical excitation and caused an ...
Simultaneous inhibition of oxidation and autophosphorylation of CaMKII prevented the maintenance of LTF, suggesting that both mechanisms contribute to sustained ...
Aug 3, 2018 · We hypothesize that pathological mdROS can cause erratic action potentials through the oxidation‐dependent CaMKII activation pathway. We further ...