Functional imaging techniques play a major role in the study of brain activation by monitoring the changes in blood flow and energy metabolism.

In the case of Alzheimer's disease, the effect of halved cerebral blood flow increase results in a negative BOLD signal implying suppressed neural activity.

Oct 22, 2024 · When calcium dynamics are included in the model, both BOLD signal and metabolite concentration profiles are shown to exhibit temporal behaviour ...

Apr 1, 2005 · A model of the coupling between brain electrical activity, metabolism, and hemodynamics: application to the interpretation of functional neuroimaging.

The neurovascular coupling (NVC) connects cerebral activity, blood flow, and metabolism. This interconnection is used in for instance functional imaging, which ...

Jan 3, 2017 · This article updates the Calcium Hypothesis of Alzheimer's disease and brain aging on the basis of emerging evidence since 1994.

The model describes the dynamic sequence from neuronal stimulation to metabolic and vascular response and predicts the effect of changes in enzyme activity, ...

May 1, 2020 · We find increased mitochondrial Ca 2+ levels associated with plaque deposition and neuronal death in a transgenic mouse model of cerebral β-amyloidosis.

Aug 31, 2023 · Modelling of calcium dynamics in brain energy metabolism and Alzheimer's disease. Comput. Biol. Chem . 29, 151–162. doi: 10.1016/j ...

Our study showed that Alzheimer's astrocytes can change the functional pattern of the calcium activity of healthy nerve cells.