For each scenario with two endpoints the optimal power tests are calculated under three different assumptions matching the three overall scenarios of an effect ...
Dec 22, 2016 · We propose improved exact multiple testing procedures for the setting where two parallel groups are compared in multiple binary endpoints. Based ...
Dec 22, 2016 · We propose improved exact multiple test- ing procedures for the setting where two parallel groups are compared in multiple binary endpoints.
Calculates global tests and multiple testing procedures to compare two groups with respect to mul- tiple binary endpoints based on optimal rejection regions.
Improved exact multiple testing procedures are proposed for the setting where two parallel groups are compared in multiple binary endpoints. Based on the joint ...
Oct 13, 2021 · Based on the association measure among latent variables, we provide a statistic for testing the superiority of at least one binary endpoint.
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How- ever, tests for multiple endpoints are generally confirmatory in nature required for drug approval and labeling. • The problem of testing multiple ...
Mar 28, 2024 · The introduced optimized futility boundaries aim to maximize the probability of correctly stopping for futility in case of small or opposite effects.
Broadly speaking, there are two inferential goals when dealing with multiple endpoints. Goal 1 is to establish an overall treatment effect using a test of the ...
Missing: Optimal | Show results with:Optimal
Numeric optimization algorithms can be applied to find multivariate rejection regions of arbitrary shape that result in exact tests with maximal exhaustion of ...