The goal of this paper is to introduce PNA in the area of computation with biomolecules, and to discuss its possible role in overcoming some of the drawbacks ...
Compared to DNA probes, PNAs have been shown to be efficient tools in numerous applications, since they can form duplexes more stable than double-stranded DNA ...
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Sep 23, 2015 · Our results show that PNA allows for toehold-free strand displacement and that incorporation yield depends critically on binding site geometry.
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Molecular Computing by PNA: PNA duplex formation: Artificial DNA
www.tandfonline.com › adna.2.1.15459
Abstract. Molecular computing is potentially one of the most powerful tools for the development of massive parallel computing protocols.
Aug 10, 2023 · Programmable site-specific nucleases promise to unlock myriad applications in basic biology research, biotechnology and gene therapy.
Sep 6, 2023 · In this report, we describe the synthesis and polynucleotide hybridization properties of a novel cationic/amino-alkyl nucleotide base-modified PNA (OPNA).
Focus on PNA Flexibility and RNA Binding using Molecular Dynamics ...
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Feb 17, 2017 · Peptide Nucleic Acids (PNAs) can efficiently target DNA or RNA acting as chemical tools for gene regulation. Their backbone modification and ...
In this work, we show that Bragg grating PCFs after internal modification with peptide nucleic acid (PNA) probes can be used to perform nanoparticle-enhanced ...
They bind DNA and RNA with high specificity and selectivity, leading to PNA–RNA and PNA–DNA hybrids more stable than the corresponding nucleic acid complexes.
Feb 29, 2024 · Studies have shown that γ-position modifications can preorganize PNA into a helical structure, enhancing its DNA or RNA invasion abilities.