We have recently described a new conformational search strategy for protein folding algorithms called the CGU (convex global underestimator) method.
Oct 22, 2024 · Here we use a simplified protein chain representation and a differentiable form of the Sun/Thomas/Dill energy function to test the CGU method.
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Protein Structure and Energy Landscape Dependence on Sequence Using a Continuous Energy Function. K.A. DILL,1 A.T. PHILLIPS,2 and J.B. ROSEN3. ABSTRACT. We ...
Summary: This work uses a simplified protein chain representation and a differentiable form of the Sun/Thomas/Dill energy function to test the CGU (convex ...
Protein structure prediction and potential energy landscape analysis using continuous global minimization. Authors: Ken A. Dill, Andrew T. Phillips, J. Ben ...
Mar 29, 2019 · The underlying rationale is that each energy function determines a specific energy landscape together with a native attraction-basin, and the ...
The protein energy landscape theory is used to obtain optimal energy functions for protein structure prediction via simulated annealing.
Protein Structure and Energy Landscape Dependence on Sequence Using a Continuous Energy Function. Article. Full-text available. Feb 1997. Ken A Dill ...
Recent advances in computational protein design have allowed exciting new insights into the sequence dependence of protein folding free energy landscapes.
Jul 24, 2020 · The protein design problem is to identify an amino acid sequence which folds to a desired structure. Given Anfinsen's thermodynamic hypothesis ...
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