Mar 22, 2013 · Here a novel structural model of hERG is presented encompassing the full transmembrane segment of hERG, including the conduction pore and the ...
Here a novel structural model of hERG is presented encompassing the full transmembrane segment of hERG, including the conduction pore and the voltage sensitive ...
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Mar 22, 2013 · Subsequent mole- cular dynamics simulations allow gaining novel structural and dynamic insights into hERG functioning and perturbation.
PDF | On Mar 22, 2013, Peter Schmidtke and others published Towards a complete structure of the hERG channel | Find, read and cite all the research you need ...
Here a novel structural model of hERG is presented encompassing the full transmembrane segment of hERG, including the conduction pore and the voltage sensitive ...
The recent determination of the near atomic resolution structure of the hERG K+ channel, using single particle cryo-EM, provides tremendous insights into the ...
Here we describe an update of recent research that addresses the nature of the particular gated state of hERG captured in the new structure.
The presence of hydrophobic pouches sprouting from the central cavity provides a plausible explanation for the promiscuity of drug binding to hERG K+ channels.
Cryo-EM Structure of K+-Bound hERG Channel Complexed with the ...
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Jan 14, 2021 · The three-dimensional structure of the hERG channel was recently reported at 3.8-Å resolution using cryogenic electron microscopy (cryo-EM).
Aug 11, 2021 · Computational models of hERG potassium channel provide structural insights into an inactivated state and associated drug interactions.