Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to tre... more Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.
The American Journal of Gastroenterology, Sep 1, 2007
Cobiprostone has only a small effect on cAMP levels in T84 cells, precluding a role of cAMP in th... more Cobiprostone has only a small effect on cAMP levels in T84 cells, precluding a role of cAMP in the protective action of cobiprostone. Indomethacin caused depolarization of the mitochondrial membrane potential. Cobiprostone protected against indomethacin-induced depolarization of mitochondrial membrane potential and reversed the loss of mitochondrial membrane potential. Cobiprostone was also shown to protect against cytochrome c relocation from mitochondria into the cytoplasm, which is associated with apoptosis. Finally, in a novel long-term assay using T84 cell cultures, cobiprostone reduced indomethacin-induced cell death and promoted cell regrowth. Conclusion: Activation of Cl -channels may underlie the protective effects of cobiprostone in protection against NSAID-induced damage. The results further indicate that cobiprostone has the potential to be of benefit against NSAID-induced cell death.
Infliximab is a monoclonal antibody that antagonizes the activity of tumor necrosis factor alpha ... more Infliximab is a monoclonal antibody that antagonizes the activity of tumor necrosis factor alpha to induce and maintain remission in patients with inflammatory bowel disease. Adverse effects associated with Infliximab infusions include infusion reactions, risk of infections, development of hematological malignancies, and pancytopenia. Autoimmune hemolytic anemia has rarely been reported in ulcerative colitis. Herein we report a case of drug-induced hemolytic anemia after infliximab infusion for treating ulcerative colitis.
How Accurate Is Endoscopic Ultrasound in Staging Perirectal Nodal Invasion By Rectal Cancers? A Meta-Analysis and Systematic Review
Gastrointestinal Endoscopy, Apr 1, 2008
Gastrointestinal Endoscopy, Volume 67, Issue 5, Pages AB241, April 2008, Authors:Srinivas R. Puli... more Gastrointestinal Endoscopy, Volume 67, Issue 5, Pages AB241, April 2008, Authors:Srinivas R. Puli; Jyotsna Bk Reddy; Matthew L. Bechtold; Praveen K. Roy; Jack D. Bragg; Priya D. Ravindran; Jamal A. Ibdah; Mainor R. Antillon. ...
M1117 Accuracy of Endoscopic Ultrasound in Diagnosing Various T-Stages of Rectal Cancers: A Meta-Analysis and Systematic Review
Gastroenterology, Apr 1, 2008
Gastroenterology, Volume 134, Issue 4, Pages A-341, April 2008, Authors:Srinivas R. Puli; Jyotsna... more Gastroenterology, Volume 134, Issue 4, Pages A-341, April 2008, Authors:Srinivas R. Puli; Jyotsna BK Reddy; Matthew L. Bechtold; Praveen K. Roy; Jack D. Bragg; Priya D. Ravindran; Jamal A. Ibdah; Mainor R. Antillon. ...
Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to tre... more Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.
Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to tre... more Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.
The American Journal of Gastroenterology, Sep 1, 2007
Cobiprostone has only a small effect on cAMP levels in T84 cells, precluding a role of cAMP in th... more Cobiprostone has only a small effect on cAMP levels in T84 cells, precluding a role of cAMP in the protective action of cobiprostone. Indomethacin caused depolarization of the mitochondrial membrane potential. Cobiprostone protected against indomethacin-induced depolarization of mitochondrial membrane potential and reversed the loss of mitochondrial membrane potential. Cobiprostone was also shown to protect against cytochrome c relocation from mitochondria into the cytoplasm, which is associated with apoptosis. Finally, in a novel long-term assay using T84 cell cultures, cobiprostone reduced indomethacin-induced cell death and promoted cell regrowth. Conclusion: Activation of Cl -channels may underlie the protective effects of cobiprostone in protection against NSAID-induced damage. The results further indicate that cobiprostone has the potential to be of benefit against NSAID-induced cell death.
Infliximab is a monoclonal antibody that antagonizes the activity of tumor necrosis factor alpha ... more Infliximab is a monoclonal antibody that antagonizes the activity of tumor necrosis factor alpha to induce and maintain remission in patients with inflammatory bowel disease. Adverse effects associated with Infliximab infusions include infusion reactions, risk of infections, development of hematological malignancies, and pancytopenia. Autoimmune hemolytic anemia has rarely been reported in ulcerative colitis. Herein we report a case of drug-induced hemolytic anemia after infliximab infusion for treating ulcerative colitis.
How Accurate Is Endoscopic Ultrasound in Staging Perirectal Nodal Invasion By Rectal Cancers? A Meta-Analysis and Systematic Review
Gastrointestinal Endoscopy, Apr 1, 2008
Gastrointestinal Endoscopy, Volume 67, Issue 5, Pages AB241, April 2008, Authors:Srinivas R. Puli... more Gastrointestinal Endoscopy, Volume 67, Issue 5, Pages AB241, April 2008, Authors:Srinivas R. Puli; Jyotsna Bk Reddy; Matthew L. Bechtold; Praveen K. Roy; Jack D. Bragg; Priya D. Ravindran; Jamal A. Ibdah; Mainor R. Antillon. ...
M1117 Accuracy of Endoscopic Ultrasound in Diagnosing Various T-Stages of Rectal Cancers: A Meta-Analysis and Systematic Review
Gastroenterology, Apr 1, 2008
Gastroenterology, Volume 134, Issue 4, Pages A-341, April 2008, Authors:Srinivas R. Puli; Jyotsna... more Gastroenterology, Volume 134, Issue 4, Pages A-341, April 2008, Authors:Srinivas R. Puli; Jyotsna BK Reddy; Matthew L. Bechtold; Praveen K. Roy; Jack D. Bragg; Priya D. Ravindran; Jamal A. Ibdah; Mainor R. Antillon. ...
Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to tre... more Those patients with perianal Crohn's disease or ul cerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.
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