Background: Hospitalized patients with tuberculosis (TB) are prescribed with drugs having high ri... more Background: Hospitalized patients with tuberculosis (TB) are prescribed with drugs having high risk of potential drug-drug interactions (pDDIs) and adverse drug effects (ADEs). Objectives: To explore the adverse effects of anti-tuberculosis (anti-TB) drugs and the prevalence and predictors of pDDIs in hospitalized patients with TB. Methods: Clinical profiles of 436 TB patients were reviewed for adverse effects induced by anti-TB drugs and screened for pDDIs using Micromedex-DrugReax. Prevalence and severity levels of pDDIs were reported. Odds-ratios for predictors were calculated using logistic regression analysis. Results: Of total 436 patients, adverse effects of anti-TB drugs were found in 36%. ADEs were highly prevalent in patients with high doses of anti-TB drugs. Hepatotoxicity, neuropathy, insomnia, arthralgia, psychosis, hematological alterations, skin rashes, red color stool, diplopia, and photophobia were the identified ADEs. All drugs types-and anti-TB drugs-pDDIs were reported in 78.2% and 55.7%, respectively. Major-pDDIs of anti-TB drugs were identified in 55.5%. Total 1090 anti-TB drugs pDDIs were found, among them, 55.6% were of major-and 40.5% moderate-severity. Significant association was observed for the pDDIs with ≥7 prescribed medicines (p<0.001). Potential adverse outcomes of the most frequent interactions were hepatotoxicity, decreased drug's effectiveness, QT-interval prolongation, nephrotoxicity, and gastrointestinal ulceration. Conclusions: Patients with TB present with a considerable number of clinically important pDDIs and ADEs (particularly hepatotoxicity). TB patients should be monitored for adverse Accepted Article This article is protected by copyright. All rights reserved effects of anti-TB drugs. Attention should be given to major-pDDIs. Patients more at risk to interactions should be identified and monitored for related adverse outcomes.
The present phenomenological study aimed to explore the perceptions and experiences of veil-takin... more The present phenomenological study aimed to explore the perceptions and experiences of veil-taking women. For this purpose, semi-structured interviews were conducted with 15 purposefully selected Pakistani veil-taking women. Construct validity of the tool was checked through expert opinion from 5 experts from social sciences and qualitative research fields. Respondents reported three main reasons for taking the veil: Islam and Quranic values, family norms, and fashion. All the participants looked at their veil approvingly and considered it a sign of respect, freedom, and empowerment. However, some women reported that they had faced prejudice, discrimination, and stereotypical attitude due to their veil. The study suggests that wearing a veil or not should be the right of a woman. Neither should a person be ridiculed, harassed, or discriminated for taking; nor for not taking it.
Background: Hospitalized patients with tuberculosis (TB) are prescribed with drugs having high ri... more Background: Hospitalized patients with tuberculosis (TB) are prescribed with drugs having high risk of potential drug-drug interactions (pDDIs) and adverse drug effects (ADEs). Objectives: To explore the adverse effects of anti-tuberculosis (anti-TB) drugs and the prevalence and predictors of pDDIs in hospitalized patients with TB. Methods: Clinical profiles of 436 TB patients were reviewed for adverse effects induced by anti-TB drugs and screened for pDDIs using Micromedex-DrugReax. Prevalence and severity levels of pDDIs were reported. Odds-ratios for predictors were calculated using logistic regression analysis. Results: Of total 436 patients, adverse effects of anti-TB drugs were found in 36%. ADEs were highly prevalent in patients with high doses of anti-TB drugs. Hepatotoxicity, neuropathy, insomnia, arthralgia, psychosis, hematological alterations, skin rashes, red color stool, diplopia, and photophobia were the identified ADEs. All drugs types-and anti-TB drugs-pDDIs were reported in 78.2% and 55.7%, respectively. Major-pDDIs of anti-TB drugs were identified in 55.5%. Total 1090 anti-TB drugs pDDIs were found, among them, 55.6% were of major-and 40.5% moderate-severity. Significant association was observed for the pDDIs with ≥7 prescribed medicines (p<0.001). Potential adverse outcomes of the most frequent interactions were hepatotoxicity, decreased drug's effectiveness, QT-interval prolongation, nephrotoxicity, and gastrointestinal ulceration. Conclusions: Patients with TB present with a considerable number of clinically important pDDIs and ADEs (particularly hepatotoxicity). TB patients should be monitored for adverse Accepted Article This article is protected by copyright. All rights reserved effects of anti-TB drugs. Attention should be given to major-pDDIs. Patients more at risk to interactions should be identified and monitored for related adverse outcomes.
The present phenomenological study aimed to explore the perceptions and experiences of veil-takin... more The present phenomenological study aimed to explore the perceptions and experiences of veil-taking women. For this purpose, semi-structured interviews were conducted with 15 purposefully selected Pakistani veil-taking women. Construct validity of the tool was checked through expert opinion from 5 experts from social sciences and qualitative research fields. Respondents reported three main reasons for taking the veil: Islam and Quranic values, family norms, and fashion. All the participants looked at their veil approvingly and considered it a sign of respect, freedom, and empowerment. However, some women reported that they had faced prejudice, discrimination, and stereotypical attitude due to their veil. The study suggests that wearing a veil or not should be the right of a woman. Neither should a person be ridiculed, harassed, or discriminated for taking; nor for not taking it.
Uploads
Papers by Sidra Noor