Dr. Pravin D. Potdar
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Dr. Pravin D. Potdar

EX-Head & Chief of Department Molecular Medicine and Biology,
Jaslok Hospital and Research Centre, Mumbai, India

Highest Degree
Ph.D. in Applied Biological Sciences from Mumbai University, India

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Biography

I have been a pioneer scientist in the field of cancer research & stem cells for the last 35 years. I worked as a senior scientist for 20 years at Tata Memorial Centre and was Head and Chief Molecular Medicine and Biology Laboratory at Jaslok Hospital & Research Centre, Mumbai, I was a recipient of the prestigious National Institute of Health(NIH)and M.D.Anderson Cancer Centre, USA award.

Area of Interest:

Molecular Sciences
100%
Molecular Biomarkers
62%
Stem Cell Therapy
90%
Cell Proliferation
75%
Stem Cell
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
58
Abstracts
1

Selected Publications

  1. Gautam, S., S.D. Purohit, H. Singh, A.K. Dinda, P.D. Potdar, C. Sharma, Chia-Fu Chou and N.C. Mishra, 2022. Surface modification of pcl-gelatin-chitosan nanofibrous scaffold by nanohydroxyapatite for bone tissue engineering. SSRN J., 10.2139/ssrn.4188579.
    CrossRef  |  Direct Link  |  
  2. Gautam, S., S.D. Purohit, H. Singh, A.K. Dinda, P.D. Potdar, C. Sharma, Chia-Fu Chou and N.C. Mishra, 2022. Surface modification of PCL-gelatin-chitosan electrospun scaffold by nano-hydroxyapatite for bone tissue engineering. Mater. Today Commun., Vol. 34. 10.1016/j.mtcomm.2022.105237.
    CrossRef  |  Direct Link  |  
  3. Gautam, S., C. Sharma, S.D. Purohit, H. Singh, A.K. Dinda, P.D. Potdar, Chia-Fu Chou and N.C. Mishra, 2021. Gelatin-polycaprolactone-nanohydroxyapatite electrospun nanocomposite scaffold for bone tissue engineering. Mater. Sci. Eng.: C, Vol. 119. 10.1016/j.msec.2020.111588.
    CrossRef  |  Direct Link  |  
  4. Potdar, P.D., 2017. Circulating tumor cells: Hope to diagnose and treat metastatic cancer. J. Cancer Metastasis Treat., 3: 1-5.
    CrossRef  |  Direct Link  |  
  5. Potdar, P.D. and S. Chaudhary, 2017. Molecular characterization of cancer-associated fibroblasts isolated from human colorectal cancer as a major stromal cell component promoting metastasis. J. Unexplored Med., 2: 1-8.
    Direct Link  |  
  6. Potdar, P.D. and K. Sen, 2017. Profiling of circulating tumor cells in liquid biopsies from metastatic cancer patients. J. Cancer Metastasis Treat., 3: 6-15.
    CrossRef  |  Direct Link  |  
  7. Potdar, P. and S. Chaudhary, 2017. Current challenges in the therapeutic use of Induced Pluripotent Stem Cells (iPSCs) in cancer therapy. Applied Cancer Res., Vol. 37. 10.1186/s41241-017-0015-y.
    CrossRef  |  Direct Link  |  
  8. Potdar, P.D. and S. Choudhary, 2016. Cancer immunotherapy: New technology to target cancer cells. MOJ Cell Sci. Rep., Vol. 3, No. 4. .
    Direct Link  |  
  9. Potdar, P.D. and M.B. Chaudhari, 2016. Cellular, molecular and therapeutic advances in type 2 diabetes mellitus. Diabetes Manage., 6: 30-44.
    Direct Link  |  
  10. Potdar, P.D. and A.V. Shetti, 2016. Chitosan nanoparticles: An emerging weapon against the cancer. MOJ Cell Sci. Rep., Vol. 3, No. 2. .
    Direct Link  |  
  11. Potdar, P.D. and A.U. Shetti, 2016. Molecular biomarkers for diagnosis and therapies of Alzheimer's disease. AIMS Neurosci., 3: 433-453.
    CrossRef  |  Direct Link  |  
  12. Potdar, P.D. and A.U. Shetti, 2016. Evaluation of anti-metastatic effect of chitosan nanoparticles on esophageal cancer-associated fibroblasts. J. Cancer Metastasis Treat., 2: 259-267.
    CrossRef  |  Direct Link  |  
  13. Potdar, P. and Y. Jethmalani, 2015. Human dental pulp mesenchymal stem cells and their applications in future regenerative medicine. World J. Stem Cell, 7: 839-851.
  14. Potdar, P. and N.K. Lotey, 2015. Role of circulating tumor cells in future diagnosis and therapy of cancer. J Cancer Metastasis Treat., 1: 44-56.
    CrossRef  |  Direct Link  |  
  15. Potdar, P.D. and S. Chaugule, 2014. Development and molecular characterization of human placental mesenchymal stem cells from human aborted fetal tissue as a model to study mechanism of spontaneous abortion. Adv. Stem Cells. 10.5171/2014.685337.
    CrossRef  |  Direct Link  |  
  16. Potdar, P. and S. Tyagi, 2014. HBx gene expression is a sensitive indicator of chronic Hepatitis B infection than expression of HBV surface, core and polymerase gene. Int. J. Curr. Microbiol. Applied Sci., 3: 765-774.
  17. Gautam, S., C.F. Chou, A.K. Dinda, P.D. Potdar and N.C. Mishra, 2014. Surface modification of nanofibrous polycaprolactone/gelatin composite scaffold by collagen type I grafting for skin tissue engineering. Mater. Sci. Eng.: C, 34: 402-409.
    CrossRef  |  Direct Link  |  
  18. Gautam, S., C.F. Chou, A.K. Dinda, P.D. Potdar and N.C. Mishra, 2014. Fabrication and characterization of PCL/gelatin/chitosan ternary nanofibrous composite scaffold for tissue engineering applications. J. Mater. Sci., 49: 1076-1089.
    CrossRef  |  Direct Link  |  
  19. Potdar, P.D., S. Deshpande and S. Chaugule, 2013. Development and molecular characterization of cystic hygroma cell line to be used as an in vitro model system to study the progression of hygroma in young children. Pediatr. Res. Int. J. 10.5171/2013.879081.
    CrossRef  |  Direct Link  |  
  20. Potdar, P.D., 2013. Molecular Biomarkers for Cancer. In: Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications, Shiddiky, M.J.A., E.J.H. Wee, S. Rauf and M. Trau (Eds.). Chapter 7, Nova Scientific Publication, USA., ISBN: 978-1-62808-020-9, pp: 133-166.
  21. Potdar, P.D. and S.S. Deshpande, 2013. Mesenchymal stem cell transplantation: New avenues for stem cell therapies. J. Transplant. Technol. Res., Vol. 3. 10.4172/2161-0991.1000122.
    CrossRef  |  Direct Link  |  
  22. Potdar, P.D. and P. Prasannan, 2013. Differentiation of human dermal mesenchymal stem cells into cardiomyocytes by treatment with 5-azacytidine: Concept for regenerative therapy in myocardial infarction. ISRN Stem Cells. 10.1155/2013/687282.
    CrossRef  |  Direct Link  |  
  23. Potdar, P.D. and A. Raghu, 2013. Review on molecular diagnostic techniques in Friedreich's ataxia. Annu. Rev. Res. Biol., 3: 659-677.
    Direct Link  |  
  24. Potdar, P.D. and A. Raghu, 2013. Molecular diagnosis of Friedreich ataxia using analysis of GAA repeats and FXN gene exons in population from Western India. Asian J. Neurosci. 10.1155/2013/909767.
    CrossRef  |  Direct Link  |  
  25. Potdar, P. and P. Thakur, 2013. Development of sequence based molecular diagnostic test to evaluate MDR and XDR in M. tuberculosis patients from Western India. Am. J. Infect. Dis. Microbiol., 1: 50-58.
    CrossRef  |  Direct Link  |  
  26. Potdar, P. and K.S. Kumar, 2013. Establishment and molecular characterization of human dermal mesenchymal-like stem cells derived from human scalp biopsy of androgenetic alopecia patient. Stem Cell Discov., 3: 77-82.
    CrossRef  |  Direct Link  |  
  27. Gupta, S.K., P.D. Potdar, A.K. Dinda and N.C. Mishra, 2013. Surface modified goat-lung decellularized scaffold for bio-artificial skin tissue engineering applications. J. Biomater. Tissue Eng., 3: 643-652.
    CrossRef  |  Direct Link  |  
  28. Gupta, S.K., A.K. Dinda, P.D. Potdar and N.C. Mishra, 2013. Modification of decellularized goat-lung scaffold with chitosan/nanohydroxyapatite composite for bone tissue engineering applications. BioMed Res. Int. 10.1155/2013/651945.
    CrossRef  |  Direct Link  |  
  29. Gupta, S.K., A.K. Dinda, P.D. Potdar and N.C. Mishra, 2013. Fabrication and characterization of scaffold from cadaver goat-lung tissue for skin tissue engineering applications. Mater. Sci. Eng.: C, 33: 4032-4038.
    CrossRef  |  Direct Link  |  
  30. Potdar, P.D. and S.R. Chaugule, 2012. Defining heterogeneity of human non-metastatic breast cancer tumor by identifying individual cell types using cellular and molecular markers. Stem Cell Stud., 2: 21-26.
    Direct Link  |  
  31. Potdar, P. and F. Monteiro, 2012. Localization and molecular characterization of human breast cancer initiating cells from heterogeneous population of breast cancer mesenchymal stem cells by immunofluorescence microscopy. J. Stem Cells Regen. Med., 8: 190-197.
    Direct Link  |  
  32. Potdar, P.D., B.S. Daswani and N.J. Rane, 2011. Drug resistance mutations to protease and reverse transcriptase inhibitors in treatment naive HIV-1 clade C infected individuals from Mumbai, India. Int. J. Virol., 7: 13-23.
    CrossRef  |  
  33. Potdar, P.D. and S.B. D'Souza, 2011. Isolation of Oct4+, Nanog+ and SOX2- mesenchymal cells from peripheral blood of a diabetes mellitus patient. Hum. Cell, 24: 51-55.
    CrossRef  |  Direct Link  |  
  34. Potdar, P.D. and R.P. Subedi, 2011. Defining molecular phenotypes of mesenchymal and hematopoietic stem cells derived from peripheral blood of acute lymphocytic leukemia patients for regenerative stem cell therapy. J. Stem Cells Regen. Med., 7: 29-40.
    Direct Link  |  
  35. Potdar, P. and S. Chaugule, 2011. Establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non-metastasis breast cancer tumor. Stem Cell Discov., 1: 21-28.
    CrossRef  |  Direct Link  |  
  36. Potdar, P.D. and S.B. D'Souza, 2010. Ascorbic acid induces in vitro proliferation of human subcutaneous adipose tissue derived mesenchymal stem cells with upregulation of embryonic stem cell pluripotency markers Oct4 and SOX 2. Hum. Cell, 23: 152-155.
    CrossRef  |  Direct Link  |  
  37. Potdar, P. and J. Sutar, 2010. Establishment and molecular characterization of mesenchymal stem cell lines derived from human visceral and subcutaneous adipose tissues. J. Stem Cells Regen. Med., 6: 26-35.
    PubMed  |  Direct Link  |  
  38. Pattani, A., V.B. Patravale, L. Panicker and P.D. Potdar, 2009. Immunological effects and membrane interactions of chitosan nanoparticles. Mol. Pharm., 6: 345-352.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Takada, Y., A. Bhardwaj, P. Potdar and B.B. Aggarwal, 2004. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1 and abrogation of tumor cell proliferation. Oncogene, 23: 9247-9258.
    CrossRef  |  Direct Link  |  
  40. Shishodia, S., P. Potdar, C.G. Gairola and B.B. Aggarwal, 2003. Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-κB activation through inhibition of IκBα kinase in human lung epithelial cells: Correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis, 24: 1269-1279.
    CrossRef  |  Direct Link  |  
  41. Shah, M.D., A.G. Ramchandani, M.B. Mahimkar, P.D. Potdar, A.N. Bhisey and R.A. Bhisey, 2001. Effects of an aqueous extract of processed bidi tobacco on the growth of hamster tracheal epithelial cells. Toxicol. Lett., 119: 1-9.
    CrossRef  |  Direct Link  |  
  42. Andrews, K.L., P.D. Potdar, P. Nettesheim and L.E. Ostrowski, 2000. KPL1, which encodes a novel PH domain-containing protein, is induced during ciliated cell differentiation of rat tracheal epithelial cells. Exp. Lung Res., 26: 257-271.
    CrossRef  |  Direct Link  |  
  43. Potdar, P.D. and A.N. Bhisey, 1999. Establishment and characterization of normal and initiated hamster tracheal epithelial cell system. Cell Proliferation, 32: 1-13.
    CrossRef  |  Direct Link  |  
  44. Ostrowski, L.E., K.L. Andrews, P.D. Potdar and P. Nettesheim, 1999. Ciliated-cell differentiation and gene expression. Protoplasma, 206: 245-248.
    CrossRef  |  Direct Link  |  
  45. Ostrowski, L.E., K. Andrews, P. Potdar, H. Matsuura, A. Jetten and P. Nettesheim, 1999. Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells. Am. J. Respir. Cell Mol. Biol., 20: 675-683.
    CrossRef  |  Direct Link  |  
  46. Ostowski, L., K. Andrew, P. Potdar and P. Nettesheim, 1998. Regulation of Ciliogenesis and Ciliated Cell Specific Genes. In: Cilia, Mucus and Mucociliary Interactions, Liron, N., E. Ostfeld, Z. Priel and Y. Roth (Eds.). Chapter 6, CRC Press, Boca Raton, FL., USA., ISBN-13: 9780824701383, pp: 43-48.
  47. Potdar, P.D., K.L. Andrews, P. Nettesheim and L.E. Ostrowski, 1997. Expression and regulation of γ-glutamyl transpeptidase-related enzyme in tracheal cells. Am. J. Physiol.-Lung Cell. Mol. Physiol., 273: L1082-L1089.
    Direct Link  |  
  48. Potdar, P.D., S.V. Kandarkar and S.M. Sirsat, 1992. Modulation by vitamin C of tumour incidence and inhibition in oral carcinogenesis. Funct. Dev. Morphol., 2: 167-172.
    PubMed  |  Direct Link  |  
  49. Potdar, P.D., S.V. Kandarkar and S.M. Sirsat, 1989. Light and electron microscopic study of hamster cheek pouch treated with 9,10 dimethyl 1,2 benzanthracene and retinoic acid. Ann. Acad. Med. Singapore, 18: 523-527.
    PubMed  |  Direct Link  |  
  50. Potdar, P.D., S.V. Kandarkar and S.M. Sirsat, 1988. Effect of DMBA and retinyl acetate on DMBA induced carcinogenesis in the hamster cheek pouch. Indian J. Exp. Biol., 26: 205-211.
  51. Kandarkar, S.V., P.D. Potdar and S.M. Sirsat, 1983. Dose response effect of retinyl acetate on DMBA induced carcinogenesis in the hamster cheek pouch. Neoplasma, 31: 415-421.
    PubMed  |  Direct Link  |  
  52. Potdar, P.D. and U.M. Joshi, 1981. Assessment of vitamin C in women taking oral combination contraceptives. J. Obst. Gyanecol., 31: 895-897.
  53. Lahiri, A., P.D. Potdar and U.M. Joshi, 1980. Fluctuation in erythrocytes enzymes in individuals. Indian J. Med. Res., 71: 256-262.

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