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Immunology news
Oncology & Cancer
'Smart,' ultrasound-activated immune cells may soon provide long-lasting tumor destruction
Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors—a smart fighter that destroys cancer cells for days without tiring. USC biomedical engineers have made this concept a reality, ...
20 hours ago
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Oncology & Cancer
HLA-DRB1 molecule offers potential target for CAR therapy in relapsed acute myeloid leukemia post-transplantation
One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules only expressed by cancer ...
21 hours ago
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Researchers investigate characteristics of lymphocytes that prolong atopic dermatitis
Atopic dermatitis is an allergy affecting approximately 10% of the Japanese population, with symptoms closely related to social stress. In socially active adults, the disease often becomes chronic.
21 hours ago
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An immune cell may explain how maternal inflammation causes neurodevelopmental disorder
A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. The research suggests the role of CD11c-positive ...
Apr 1, 2025
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Combination immunotherapy shrinks a variety of metastatic gastrointestinal cancers in clinical trial
A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to ...
Apr 1, 2025
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Computational platform helps unlock A20's dual role in cancer immunotherapy
There is an urgent need for precision immunotherapy strategies that simultaneously target both tumor cells and immune cells to enhance treatment efficacy. Identifying genes with dual functions in both cancer and immune cells ...
Apr 1, 2025
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IL-7 treatment shows promise in reducing lethal secondary infections in critically ill COVID-19 patients
A new study published in JCI Insight suggests that interleukin-7 (IL-7), a key immune-boosting cytokine, may help critically ill COVID-19 patients by reducing life-threatening secondary infections. Led by Richard S. Hotchkiss, ...
Apr 1, 2025
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Cancer cells 'hacked' to expose themselves to immune attack
When your social media account starts spewing out nonsensical or threatening status updates, it's safe to assume that it has been hacked and must be shut down.
Mar 31, 2025
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A hidden strategy: How SARS-CoV-2 uses fibrinogen to evade the immune system
As scientists, we often think we understand a virus—its structure, its tricks, the way it moves through the body. But every once in a while, we stumble upon something unexpected—something that completely changes the way ...
Stem cell infusion timing can prevent acute graft-versus-host disease
A research team has identified the impact of stem cell infusion timing on the incidence and severity of acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), highlighting ...
Mar 31, 2025
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Common anticancer drugs may offer new hope to PTEN Hamartoma Tumor Syndrome patients
During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways—series of signaling cascades within a cell—regulate these actions to avoid ...
Mar 31, 2025
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New thesis provides deeper understanding of fetal immune cells
Inga Rødahl from the Center for Infectious Medicine (CIM) at the Department of Medicine, Huddinge (MedH) is defending her thesis, titled "Features of innate lymphoid cells in human fetal tissues and adult respiratory infection," ...
Mar 31, 2025
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Researchers identify mutations that can lead to resistance to some chemotherapies
Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study ...
Mar 29, 2025
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How melanoma and other tumors succeed in hiding and resisting immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of mutations. Although some of these alterations should be recognized as a threat by our defenses, melanomas ...
Mar 28, 2025
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Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer, study shows
A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy.
Mar 28, 2025
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Supercomputer uncovers immune system's secret to self-tolerance
A discovery published in Nature Immunology has shed light on why the immune system is less aggressive toward self-antigens, offering new opportunities to enhance cancer immunotherapy.
Mar 28, 2025
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Scientists uncover how TBK1 and IKKε prevent premature cell death and inflammation
New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are ...
Mar 28, 2025
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Understanding the immune response to Toxoplasma gondii, a persistent pathogen
Most humans have long-lived infections in various tissues—including in the nervous system—that typically do not result in disease. The microbes associated with these infections enter a latent stage during which they quietly ...
Mar 28, 2025
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Clinical trials show new antibody therapy offers long-lasting HIV control without daily medication
If the past four decades have taught us anything about HIV, it's to adjust our expectations—despite enormous progress in controlling the virus, no treatment can yet completely eradicate HIV once it has taken hold. But promising ...
Mar 28, 2025
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Researchers identify potential drug combinations to improve breast cancer treatment: Q&A with professor of pharmacology
Triple-negative breast cancer, an aggressive type of breast cancer, accounts for 10% of all breast cancer cases in the United States annually. CD8+ T cells that normally kill cancer cells often become exhausted and stop.
Mar 28, 2025
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Nasal protein could aid in early COPD detection
Early diagnosis of COPD, chronic obstructive pulmonary disease, increases the quality of life of the patient and the efficacy of available treatments. Researchers at Karolinska Institutet have now shown that material from ...
Mar 28, 2025
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A protective immune system cell disappears from a key form of fat, but only in those who are obese
The mammalian immune system is an evolutionary wonder. It's capable of recognizing and destroying cancer cells, and it can deploy armies of antibodies against viruses, bacteria, parasites and fungi.
Study establishes cell death as a driving force in glioblastoma
Glioblastoma, one of the most aggressive and lethal brain cancers, has a five-year survival rate of only 6.9%, according to the National Brain Tumor Society. While the relationship between glioblastoma and cell death, also ...
Mar 27, 2025
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Compelling data points to a single, unknown respiratory virus as cause of Kawasaki disease
Research from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago strongly suggests that Kawasaki disease is caused by a single respiratory virus that is yet to be identified. ...
Mar 27, 2025
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Scientists discover immune cell networks driving deadly lung disease
Rutgers Health researchers have discovered that networks of misplaced immune cells drive an aggressive lung disease, potentially opening a path to new treatments for a condition that kills 80% of patients within a decade.
Mar 27, 2025
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