Hookworm infection
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Hookworm infection is a parasitic disease caused by four hookworm species that infect over 1 billion people worldwide. The most common species are Ancylostoma duodenale and Necator americanus. Infection occurs when larvae penetrate the skin and migrate to the small intestine where they attach and feed on blood, causing iron-deficiency anemia. Symptoms include fatigue, abdominal pain, and skin pallor. Heavy infections can be life-threatening in children and the elderly. Diagnosis involves finding hookworm eggs in feces. Treatment is with anthelmintic medications to kill the worms. Prevention focuses on improved sanitation to reduce environmental contamination.
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Hookworm infection
- 1. Hookworm Infection Dr. Sanjay Singh Negi
- 2. Hookworm(Ancyclostomiasis) Hookworm disease is one of the most important parasitic diseases of humans. Number of humans infected is estimated at 1.2 billion with 50,000 to 60,000 deaths each year. Causative agents: Four species can cause human infection. Ancyclostoma duodenale (Old World Hookworm) Necator americanus (New World Hookworm) Ancylostoma braziliense(Cause creeping eruptions) Ancylostoma caninum(Cause creeping eruptions)
- 4. Morphology: Adult worm – Small, greyish white, or brown Anterior end bent slightly dorsally(Hence the name Hookworm). Oral aperture opens dorsally. Species are differentiated by their buccal capsule & arrangement of rays in bursa. A.Duodenale 6 teeth(4 hook like on the ventral surface and 2 knob like on dorsal surface). Necator americanus: 2 ventral and 2 dorsal cutting plates
- 6. Females: Size: Larger(10-13 mm long X .6mm) Posterior end: Tapering, No Umbrella like expansion Genital Opening: At the junction of posterior and middle third of body Male hookworms: Size: Smaller(8-11 mm longX .45mm) Posterior end: Umbrella like expansion Genital Opening: Posteriorly opens with cloaca.
- 7. Morphology of Ancylostoma duodenale Buccal capsule contains 2 pairs of large ventral (anterior) teeth Copulatory bursa is at posterior end and contains 3 lobes supported by 13 chitinous days.
- 8. Morphology of Necator americanus Buccal capsule contains a pair of ventral and dorsal cutting plates. Copulatory bursa is at posterior end and contains 3 lobes supported by 14 chitinous days.
- 9. Location in the Host: Small intestine (jejunum, duodenum less often). Life Span: 5-7years Characteristic of Hookworm eggs 1.Identical in two species. 2.Oval or elliptical in shape 3.Colourless (Not bile stained). 4.Has clear space b/w egg and segmented ovum. 5.Floats in saturated salt solution. 6.Not infective when freshly passed Both species show high fecundity: A. duodenale produces 25,000 to 30,000 eggs/day..N. americanus produces 9,000 eggs/day.
- 11. Pathogenicity & mode of infection Disease--- Wookworm or Ancyclostomiasis. Characterised by ………………… Anaemia Mode of Infection: Whenever man walks barefoot on the faecally contaminated soil. Filariform larvae penetrate directly through the skin. Most common site: Thin skin b/w toes dorsum of the feet Inner side of the sole Infecting agent:…………………….. Migration………………………….. Portal of entry………………………… Site of Location……………………….
- 12. Pathogenic effects caused by Ancyclostome Larvae Lesion in the Skin Ancyclostome Dermatitis or Ground Itch Creepting eruption: Filariform larvae wander about through the skin in an aimless manner for several weeks and months(up to 2 years), producing a reddish itchy papule along the path traversed by the larvae(“Larvae migrans”). More commonly seen with species of parasites(A.braziliense and A.caninum). Lesion in the lungs: Bronchitis and broncho pneumonia. Eosinophilia
- 13. Pathological Problems in Humans: 1. __________________________________________(= Creeping Eruption) L3 of dog or cat hookworms enter human skin and wander about in epidermis L3 are unable to penetrate into the dermis and are eventually killed by our immune system Wandering L3 cause a red, itchy irritation Treated with thiabendazole ointment Another reason to clean up dog and cat feces!
- 15. Pathogenic effects caused by Adult worms A severe progressive anaemia of microcytic hypochromic type. ason Blood sucking by the worm. Average blood loss with N.americanus. (0.03ml). with A.duodenale(0.2ml). Chronic haemorrhages from the punctured sites. Clinical symptoms of Hookworm Anaemia Epigastric tenderness simulating duodenal ulcer. Dyspepsia, vomiting, Diarrhea. Patient may have an abnormal appetite showing a perverted taste for earth, mud or lime(Geophagy). Hypoacidity is more common. Bowels are generally constipated. Site of old haemorrhage and recent haemorrhage (Small Intestine in Ancyclostomiasis).
- 16. Skin– Sallow appearnce (light yellow colour). Mucous membrane of eyes, lips and tongue show extreme pallor. Face appears puffy with swelling of lower eyelids. Oedema of the feet and ankle. Overall patient looks plumpy with protuberant abdomen and dry lustreless hair. Growth and development in children may be retarded. Cardiovascular system is effected and may lead to circulatory failure.
- 18. Blood changes in Hookworm Infection
- 19. 3. Anemia cont. Blood loss is associated with ________________________________________ _ ________________________________________ _ • Infected adults become tired and rundown • Mental and physical retardation commonly occurs in children. Recent findings indicate that there is a reduction in gamma globulins which results in _____________________________ to other infections. Combination of these factors can be fatal.
- 20. Diagnosis DIAGNOSIS - identify the eggs in the feces All hookworm eggs look the same so can’t ID species Eggs are ovoid with thin, smooth eggshell. Size: 55-75 µm x 35-40 µm. Concentration method is generally employed.
- 21. Indirect method Blood examination to ascertain the nature of anaemia and presence of eosinophilia. Test for occult blood in the stool gives a positive reaction. Charcot-Leyden crystals found in stool.
- 22. Treatment Thiabendazole(25mg/kg for two days), pyrantel pamoate (oral dose of 10mg/kg for 3 days, maximum 1gm). Mebendazole(100mg twice daily for 3 days or 500mg once). Albendazole(400mg once). For Anaemia- Oral iron (Ferrous sulphate 200 or 400mg thrice daily). Folic acid and Vitamin B12 .
- 23. PREVENTION: 1.Attack on Larvae ___________________________________ - stop pollution of soil with infected feces This could eliminate much of the problem. 2. Personnel protection ___________________________________ - prevent penetration of skin. 3. Attack on adult parasite …………………….Prevent spread of disease(Treatment en masse).
- 24. Necator americanus(American hookworm/The New worldhook worm) First discovered in America. Most commonly seen in Sri Lanka and India. Differentiating features of two species.
- 25. Dog and Cat Hookworms Dog hookworm - Ancylostoma caninum - is easily recognized by its 3 pairs of teeth in the buccal capsule. Cat hookworm - Ancylostoma braziliense - has a pair of long teeth.
- 26. Dog and Cat Hookworms Both species inhabit the small intestine of their hosts. Life cycles and pathology are similar to human species. HUMANS may serve as accidental hosts of these hookworms when the filariform larvae (L3) penetrate human skin. L3 penetrates human skin
Editor's Notes
- #3: ¼ th of the world population has been infected. The disease is second only to ascariasis as the most common helminthic infection.
- #4: Western hemisphere, most infection are caused by N.americanus Whereas in Asia and Europe, most infection are due to A.duodenale.
- #6: Reprodcutive part of female opens ventrally at the junction of middle and posterior third of the body
- #10: Why are some eggs bile stained?Bile staining depends on the lipid content Some eggs also have receptors for bile on their surface (shell). ------------------------------------------------ The bile passes from the gallbladder into the small intestine. Ova deposited in the intestinal tract may be bile-stained as well. The pressence of bile is not the deciding factor in staining. The outer shell of the ova is important. Some species do not have bile-stained eggs. The bile staining is primarily an identification clue in the laboratory.
- #11: Man is the only definitive host for A.duodenale. No intermediate host is required. Must tell the mode of infection:
- #12: Extent of pathology is associated with the numbers of adults. Symptoms appear in infections of 100 or more worms. A heavy infection involves 500 or more worms. Symptoms are severe and the infection may be life-threatening.
- #24: 1. Proper control of sewage disposal