Abstract
Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antioxidants / administration & dosage
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Antioxidants / adverse effects
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Antioxidants / analysis
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Antioxidants / therapeutic use*
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Blood Glucose / analysis
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Brassica / chemistry*
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / diet therapy*
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Diabetes Mellitus, Type 2 / metabolism
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Dietary Supplements* / adverse effects
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Dietary Supplements* / analysis
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Double-Blind Method
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Female
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Humans
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Hyperglycemia / etiology
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Hyperglycemia / prevention & control
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Hyperinsulinism / etiology
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Hyperinsulinism / prevention & control
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Insulin / blood
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Insulin Resistance*
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Iran
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Isothiocyanates / administration & dosage
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Isothiocyanates / adverse effects
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Isothiocyanates / analysis
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Isothiocyanates / therapeutic use
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Male
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Middle Aged
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Patient Compliance
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Patient Dropouts
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Plant Shoots / chemistry*
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Sulfoxides
Substances
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Antioxidants
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Blood Glucose
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Insulin
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Isothiocyanates
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Sulfoxides
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sulforaphane