Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma.
Yamada T, Fujiwara N, Kubota N, Matsushita Y, Nakatsuka T, Kurosaki S, Minami T, Tateishi R, Ichida A, Arita J, Hasegawa K, Koike K, Fujishiro M, Nakagawa H.
Yamada T, et al.
Hepatol Commun. 2023 Jul 17;7(8):e0209. doi: 10.1097/HC9.0000000000000209. eCollection 2023 Aug 1.
Hepatol Commun. 2023.
PMID: 37471053
Free PMC article.
FINDINGS: Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tumor-associated macrophages, suggesting that lenvatinib-treated HCC is in the so-called excluded condition that can diminish ICI efficacy....
FINDINGS: Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tu …