Просмотр кода страницы CD79B

{{Infobox_gene}}
'''''CD79B''''' ({{lang-en|B-cell antigen receptor complex-associated protein beta chain}}) — [[мембранный белок]], продукт гена человека ''CD79B''<ref name="entrez">{{cite web | title = Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=974}}</ref>. Вместе с родственным белком ''[[CD79A]]'' образует гетеродимер, ассоциированный с мембрано-связанным [[иммуноглобулин]]ом на поверхности [[B-лимфоцит]]а, что формирует [[B-клеточный рецептор]]. Аналогичным образом ''CD79A'' ассоциирует с ''[[CD3 (иммунология)|CD3]]'' в [[Т-клеточный рецептор|Т-клеточном рецепторе]] и позволяет клетке отвечать на присутствие [[антиген]]а на клеточной поверхности<ref name=Leong>{{cite book | first1  = Leong | last1 = Anthony S-Y | last2 = Cooper | first2 = Kumarason | last3 = Leong | first3 = F Joel W-M | name-list-style = vanc | year = 2003 | title = Manual of Diagnostic Cytology | url  = https://archive.org/details/manualofdiagnost0000leon | edition = 2 | publisher = Greenwich Medical Media, Ltd. | pages = XX | isbn = 1-84110-100-1 }}</ref>. Ген ''CD79B'' связан с развитием агаммаглобулинемии 6-го типа<ref name="omim.org">{{OMIM|613501}}</ref>.

== Структура белка ==
''CD79B'' состоит из 229 [[Аминокислоты|аминокислот]], молекулярная масса 26,0 кДа. В результате [[Альтернативный сплайсинг|альтернативного сплайсинга]] образуются 3 изофомы<ref name=entrez />.

== Функции ==
''CD79b'' требуется вместе с ''CD79a'' для инициации сигнального каскада, активируемого комплексом [[B-клеточный рецептор|B-клеточного рецептора]], который приводит к интернализации комплекса, его переносу в поздние [[Эндосома|эндосомы]] и презентации антигена. Белок повышает фосфорилирование ''CD79a'', возможно, за счёт рекрутирования киназ, которые фосфорилируют ''CD79a'' либо за счёт рекрутирования белков, связывающихся с ''CD79a'' и защищают его от дефосфорилирования<ref name="pmid8617796">{{cite journal| author=Luisiri P, Lee YJ, Eisfelder BJ, Clark MR| title=Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex. | journal=J Biol Chem | year= 1996 | volume= 271 | issue= 9 | pages= 5158-63 | pmid=8617796 | doi=10.1074/jbc.271.9.5158 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8617796  }} </ref><ref name="pmid9057631">{{cite journal| author=Tseng J, Eisfelder BJ, Clark MR| title=B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta. | journal=Blood | year= 1997 | volume= 89 | issue= 5 | pages= 1513-20 | pmid=9057631 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9057631  }} </ref><ref name="pmid12097390">{{cite journal| author=Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M| title=B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. | journal=J Immunol | year= 2002 | volume= 169 | issue= 2 | pages= 865-72 | pmid=12097390 | doi=10.4049/jimmunol.169.2.865 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12097390  }} </ref>.

== См. также ==
* [[CD79]]
* [[CD79A]]

== Примечания ==
{{примечания}}

== Литература ==
{{refbegin}}
*{{cite journal  | author=Reth M |title=Antigen receptors on B lymphocytes |journal=Annu. Rev. Immunol. |volume=10 |pages= 97–121 |year= 1992 |pmid= 1591006 |doi= 10.1146/annurev.iy.10.040192.000525 }}
*{{cite journal  | vauthors=Müller B, Cooper L, Terhorst C |title=Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29 |journal=Eur. J. Immunol. |volume=22 |issue= 6 |pages= 1621–5 |year= 1992 |pmid= 1534761 |doi=10.1002/eji.1830220641  |s2cid=23910309 }}
*{{cite journal  | vauthors=Lankester AC, van Schijndel GM, Cordell JL |title=CD5 is associated with the human B cell antigen receptor complex |journal=Eur. J. Immunol. |volume=24 |issue= 4 |pages= 812–6 |year= 1994 |pmid= 7512031 |doi=10.1002/eji.1830240406  |s2cid=25093082 |display-authors=etal}}
*{{cite journal  | vauthors=Vasile S, Coligan JE, Yoshida M, Seon BK |title=Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex | url=https://archive.org/details/sim_molecular-immunology_1994-04_31_6/page/419 |journal=Mol. Immunol. |volume=31 |issue= 6 |pages= 419–27 |year= 1994 |pmid= 7514267 |doi=10.1016/0161-5890(94)90061-2  }}
*{{cite journal  | vauthors=Brown VK, Ogle EW, Burkhardt AL |title=Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45 |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17238–44 |year= 1994 |pmid= 7516335 |display-authors=etal}}
*{{cite journal  | vauthors=Rowley RB, Burkhardt AL, Chao HG |title=Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation |journal=J. Biol. Chem. |volume=270 |issue= 19 |pages= 11590–4 |year= 1995 |pmid= 7538118 |doi=10.1074/jbc.270.19.11590  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Pani G, Kozlowski M, Cambier JC |title=Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling | url=https://archive.org/details/sim_journal-of-experimental-medicine_1995-06_181_6/page/2077 |journal=J. Exp. Med. |volume=181 |issue= 6 |pages= 2077–84 |year= 1995 |pmid= 7539038 |doi=10.1084/jem.181.6.2077  | pmc=2192043  |display-authors=etal}}
*{{cite journal  | vauthors=Müller B, Cooper L, Terhorst C |title=Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29) |journal=Immunol. Lett. |volume=44 |issue= 2–3 |pages= 97–103 |year= 1995 |pmid= 7541024 |doi=10.1016/0165-2478(94)00199-2  }}
*{{cite journal  | vauthors=Saouaf SJ, Kut SA, Fargnoli J |title=Reconstitution of the B cell antigen receptor signaling components in COS cells |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 27072–8 |year= 1995 |pmid= 7592958 |doi=10.1074/jbc.270.45.27072  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Hashimoto S, Chiorazzi N, Gregersen PK |title=Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells | url=https://archive.org/details/sim_molecular-immunology_1995-06_32_9/page/651 |journal=Mol. Immunol. |volume=32 |issue= 9 |pages= 651–9 |year= 1995 |pmid= 7643857 |doi=10.1016/0161-5890(95)00023-8  }}
*{{cite journal  | vauthors=Hashimoto S, Chiorazzi N, Gregersen PK |title=The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism | url=https://archive.org/details/sim_immunogenetics_1994-06_40_2/page/145 |journal=Immunogenetics |volume=40 |issue= 2 |pages= 145–9 |year= 1994 |pmid= 7913081 |doi=10.1007/BF00188178  |s2cid=6966566 }}
*{{cite journal  | vauthors=Gold MR, Chiu R, Ingham RJ |title=Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes |journal=J. Immunol. |volume=153 |issue= 6 |pages= 2369–80 |year= 1994 |pmid= 8077654 |display-authors=etal}}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | vauthors=Hashimoto S, Gregersen PK, Chiorazzi N |title=The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes |journal=J. Immunol. |volume=150 |issue= 2 |pages= 491–8 |year= 1993 |pmid= 8419481 }}
*{{cite journal  | vauthors=Wood WJ, Thompson AA, Korenberg J |title=Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB) |journal=Genomics |volume=16 |issue= 1 |pages= 187–92 |year= 1993 |pmid= 8486355 |doi= 10.1006/geno.1993.1157 |display-authors=etal}}
*{{cite journal  | vauthors=Thompson AA, Wood WJ, Gilly MJ |title=The promoter and 5' flanking sequences controlling human B29 gene expression |journal=Blood |volume=87 |issue= 2 |pages= 666–73 |year= 1996 |pmid= 8555489 |doi=  10.1182/blood.V87.2.666.bloodjournal872666|display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Astsaturov IA, Matutes E, Morilla R |title=Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia |journal=Leukemia |volume=10 |issue= 5 |pages= 769–73 |year= 1996 |pmid= 8656670 |display-authors=etal}}
*{{cite journal  | vauthors=Koyama M, Nakamura T, Higashihara M |title=The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing |journal=Immunol. Lett. |volume=47 |issue= 3 |pages= 151–6 |year= 1996 |pmid= 8747711 |doi=10.1016/0165-2478(95)00071-X  |display-authors=etal}}
*{{cite journal  | vauthors=Carter RH, Doody GM, Bolen JB, Fearon DT |title=Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex |journal=J. Immunol. |volume=158 |issue= 7 |pages= 3062–9 |year= 1997 |pmid= 9120258 }}
{{refend}}

{{Кластеры дифференцировки}}

[[Категория:Кластеры дифференцировки]]