Просмотр кода страницы FCGR3B

{{Infobox_gene}}
'''''FCGR3B''''' ({{lang-en|Low affinity immunoglobulin gamma Fc region receptor III-B}}; CD16B) — [[мембранный белок]], [[клеточный рецептор]], продукт гена человека ''FCGR3B''<ref name="entrez">{{cite web | title = Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2215}}</ref>.

== Функции ==
Рецептор для ''[[Кристаллизующийся фрагмент иммуноглобулина|Fc]]''-домена [[Иммуноглобулины G|иммуноглобулинов G]] (IgG). Связывает комплексованными и аггрегированные, а также мономерный IgG. В отличие от ''[[FCGR3A]]'' ''FCGR3B'' не способен опосредовать антитело-зависимую клеточную цитотоксичность и [[фагоцитоз]]<ref name="UniProt">{{Cite web |url=https://www.uniprot.org/uniprot/O75015 |title=UniProtKB — O75015 (FCG3B_HUMAN) |access-date=2022-01-31 |archive-date=2022-01-31 |archive-url=https://web.archive.org/web/20220131210758/https://www.uniprot.org/uniprot/O75015 |deadlink=no }}</ref>.

== Структура ==
''FCGR3A'' состоит из 233 [[аминокислоты]], молекулярная масса белковой части 26 216 Да. Содережит два иммуноглобилин-подобных домена типа C2<ref name="UniProt"/>.

== Клиническое значение ==
Мутации и вариации количаства копий гена ассоциированы с развитием [[гломерулонефрит]]а<ref name=pmid.16482158>{{cite journal | vauthors = Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT | title = Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans | journal = Nature | volume = 439 | issue = 7078 | pages = 851–5 | date = Feb 2006 | pmid = 16482158 | doi = 10.1038/nature04489 | bibcode = 2006Natur.439..851A | s2cid = 4421459 }}</ref>.

== См. также ==
* [[CD16]]
* [[CD16A]]

== Примечания ==
{{примечания}}

== Литература ==
{{refbegin | 2}}
* {{cite journal | vauthors = Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV | title = Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination | journal = Science | volume = 248 | issue = 4956 | pages = 732–5 | date = May 1990 | pmid = 2139735 | doi = 10.1126/science.2139735 | bibcode = 1990Sci...248..732Q }}
* {{cite journal | vauthors = Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW | title = Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 3 | pages = 1013–7 | date = Feb 1989 | pmid = 2521732 | pmc = 286611 | doi = 10.1073/pnas.86.3.1013 | bibcode = 1989PNAS...86.1013P | doi-access = free }}
* {{cite journal | vauthors = Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP | title = A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 13 | pages = 5079–83 | date = Jul 1989 | pmid = 2525780 | pmc = 297560 | doi = 10.1073/pnas.86.13.5079 | bibcode = 1989PNAS...86.5079S | doi-access = free }}
* {{cite journal | vauthors = Ravetch JV, Perussia B | title = Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions | journal = The Journal of Experimental Medicine | volume = 170 | issue = 2 | pages = 481–97 | date = Aug 1989 | pmid = 2526846 | pmc = 2189395 | doi = 10.1084/jem.170.2.481 }}
* {{cite journal | vauthors = Simmons D, Seed B | title = The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein | journal = Nature | volume = 333 | issue = 6173 | pages = 568–70 | date = Jun 1988 | pmid = 2967436 | doi = 10.1038/333568a0 | bibcode = 1988Natur.333..568S | s2cid = 4351255 }}
* {{cite journal | vauthors = Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE | title = The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions | journal = The Journal of Biological Chemistry | volume = 270 | issue = 3 | pages = 1350–61 | date = Jan 1995 | pmid = 7836402 | doi = 10.1074/jbc.270.3.1350 | doi-access = free }}
* {{cite journal | vauthors = Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE | title = Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene | journal = The Journal of Biological Chemistry | volume = 271 | issue = 48 | pages = 30755–64 | date = Nov 1996 | pmid = 8940055 | doi = 10.1074/jbc.271.48.30755 | doi-access = free }}
* {{cite journal | vauthors = Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S | title = Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb | journal = Blood | volume = 89 | issue = 3 | pages = 1027–34 | date = Feb 1997 | doi = 10.1182/blood.V89.3.1027 | pmid = 9028335 | doi-access = free }}
* {{cite journal | vauthors = Zocchi MR, Rubartelli A, Morgavi P, Poggi A | title = HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels | journal = Journal of Immunology | volume = 161 | issue = 6 | pages = 2938–43 | date = Sep 1998 | pmid = 9743356 }}
* {{cite journal | vauthors = Sondermann P, Huber R, Oosthuizen V, Jacob U | title = The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex | journal = Nature | volume = 406 | issue = 6793 | pages = 267–73 | date = Jul 2000 | pmid = 10917521 | doi = 10.1038/35018508 | s2cid = 4306592 }}
* {{cite journal | vauthors = Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD | title = Crystal structure of the extracellular domain of a human Fc gamma RIII | journal = Immunity | volume = 13 | issue = 3 | pages = 387–95 | date = Sep 2000 | pmid = 11021536 | doi = 10.1016/S1074-7613(00)00038-8 | doi-access = free }}
* {{cite journal | vauthors = Watanabe Y, Shimada E, Fujiwara K, Niihara H, Shimano K, Mitsunaga S, Tadokoro K, Juji T | title = Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen | journal = Tissue Antigens | volume = 56 | issue = 3 | pages = 272–5 | date = Sep 2000 | pmid = 11034564 | doi = 10.1034/j.1399-0039.2000.560310.x }}
* {{cite journal | vauthors = Bharadwaj D, Mold C, Markham E, Du Clos TW | title = Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis | journal = Journal of Immunology | volume = 166 | issue = 11 | pages = 6735–41 | date = Jun 2001 | pmid = 11359830 | doi = 10.4049/jimmunol.166.11.6735 | doi-access = free }}
* {{cite journal | vauthors = Davoine F, Lavigne S, Chakir J, Ferland C, Boulay ME, Laviolette M | title = Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions | url = https://archive.org/details/sim_journal-of-allergy-and-clinical-immunology_2002-03_109_3/page/463 | journal = The Journal of Allergy and Clinical Immunology | volume = 109 | issue = 3 | pages = 463–9 | date = Mar 2002 | pmid = 11897993 | doi = 10.1067/mai.2002.121952 }}
* {{cite journal | vauthors = Fossati G, Moots RJ, Bucknall RC, Edwards SW | title = Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes | journal = Arthritis and Rheumatism | volume = 46 | issue = 5 | pages = 1351–61 | date = May 2002 | pmid = 12115243 | doi = 10.1002/art.10230 | doi-access = free }}
* {{cite journal | vauthors = Cauza K, Grassauer A, Hinterhuber G, Horvat R, Rappersberger K, Wolff K, Foedinger D | title = FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma | url = https://archive.org/details/sim_journal-of-investigative-dermatology_2002-11_119_5/page/1074 | journal = The Journal of Investigative Dermatology | volume = 119 | issue = 5 | pages = 1074–9 | date = Nov 2002 | pmid = 12445195 | doi = 10.1046/j.1523-1747.2002.19527.x | doi-access = free }}
* {{cite journal | vauthors = Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K | title = Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 374–83 | date = May 2003 | pmid = 12753656 | doi = 10.1034/j.1399-0039.2003.00047.x }}
* {{cite journal | vauthors = Breij EC, van der Pol WL, van Winsen L, Jansen MD, Dijkstra CD, van de Winkel JG, Uitdehaag BM | title = No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS | journal = Journal of Neuroimmunology | volume = 140 | issue = 1–2 | pages = 210–5 | date = Jul 2003 | pmid = 12864991 | doi = 10.1016/S0165-5728(03)00207-8 | s2cid = 53196500 }}
* {{cite journal | vauthors = Tong Y, Jin J, Yan L, Neppert J, Marget M, Flesch BK | title = FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province | journal = Annals of Hematology | volume = 82 | issue = 9 | pages = 574–8 | date = Sep 2003 | pmid = 12898191 | doi = 10.1007/s00277-003-0725-y | s2cid = 21478742 }}
* {{cite journal | vauthors = Tanaka S, Edberg JC, Chatham W, Fassina G, Kimberly RP | title = Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins | journal = Journal of Immunology | volume = 171 | issue = 11 | pages = 6090–6 | date = Dec 2003 | pmid = 14634123 | doi = 10.4049/jimmunol.171.11.6090 | doi-access = free }}
{{refend}}

{{Кластеры дифференцировки}}

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