We present a simulation framework, called NETMORPH, for the developmental generation
of 3D large-scale neuronal networks with realistic neuron morphologies. In NETMORPH,
neuronal morphogenesis is simulated from the perspective of the individual growth cone.
For each growth cone in a growing axonal or dendritic tree, its actions of elongation,
branching and turning are described in a stochastic, phenomenological manner. In this way,
neurons with realistic axonal and dendritic morphologies, including neurite curvature, can …

We present a novel simulation framework, called NETMORPH, for the developmental
generation of 3D large-scale neuronal networks with realistic neuron morphologies. Existing
models for network generation either do not consider the detailed morphology of single
neurons, or, if they do, do not take into account the developmental aspects of
morphogenesis and synapse formation. In NETMORPH, neuronal morphogenesis is
simulated from the perspective of the individual growth cone. For each growth cone in a …