AI on a chip

A Isozaki, J Harmon, Y Zhou, S Li, Y Nakagawa… - Lab on a Chip, 2020 - pubs.rsc.org
Artificial intelligence (AI) has dramatically changed the landscape of science, industry,
defence, and medicine in the last several years. Supported by considerably enhanced …

Perspectives on liquid biopsy for label‐free detection of “circulating tumor cells” through intelligent lab‐on‐chips

L Miccio, F Cimmino, I Kurelac, MM Villone, V Bianco… - View, 2020 - Wiley Online Library
Circulating tumor cells (CTCs) are rare tumor cells released from primary, metastatic, or
recurrent tumors in the peripheral blood of cancer patients. CTCs isolation from peripheral …

Multispectral quantitative phase imaging using a diffractive optical network

CY Shen, J Li, D Mengu, A Ozcan - Advanced Intelligent …, 2023 - Wiley Online Library
As a label‐free imaging technique, quantitative phase imaging (QPI) provides optical path
length information of transparent specimens for various applications in biology, materials …

PARC: ultrafast and accurate clustering of phenotypic data of millions of single cells

SV Stassen, DMD Siu, KCM Lee, JWK Ho… - …, 2020 - academic.oup.com
Motivation New single-cell technologies continue to fuel the explosive growth in the scale of
heterogeneous single-cell data. However, existing computational methods are inadequately …

Cell morphology-based machine learning models for human cell state classification

Y Li, CM Nowak, U Pham, K Nguyen… - NPJ systems biology and …, 2021 - nature.com
Herein, we implement and access machine learning architectures to ascertain models that
differentiate healthy from apoptotic cells using exclusively forward (FSC) and side (SSC) …

Deep-learning-assisted biophysical imaging cytometry at massive throughput delineates cell population heterogeneity

DMD Siu, KCM Lee, MCK Lo, SV Stassen, M Wang… - Lab on a Chip, 2020 - pubs.rsc.org
The association of the intrinsic optical and biophysical properties of cells to homeostasis and
pathogenesis has long been acknowledged. Defining these label-free cellular features …

Quantitative phase imaging flow cytometry for ultra‐large‐scale single‐cell biophysical phenotyping

KCM Lee, M Wang, KSE Cheah, GCF Chan… - Cytometry Part …, 2019 - Wiley Online Library
Cellular biophysical properties are the effective label‐free phenotypes indicative of
differences in cell types, states, and functions. However, current biophysical phenotyping …

Optofluidic imaging meets deep learning: from merging to emerging

DMD Siu, KCM Lee, BMF Chung, JSJ Wong, G Zheng… - Lab on a Chip, 2023 - pubs.rsc.org
Propelled by the striking advances in optical microscopy and deep learning (DL), the role of
imaging in lab-on-a-chip has dramatically been transformed from a silo inspection tool to a …

Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging

VK Lam, T Nguyen, V Bui, BM Chung… - … of biomedical optics, 2020 - spiedigitallibrary.org
Significance: We introduce an application of machine learning trained on optical phase
features of epithelial and mesenchymal cells to grade cancer cells' morphologies, relevant to …

Finding intracellular lipid droplets from the single-cell biolens' signature in a holographic flow-cytometry assay

D Pirone, DG Sirico, M Mugnano… - Biomedical Optics …, 2022 - opg.optica.org
In recent years, intracellular LDs have been discovered to play an important role in several
pathologies. Therefore, detection of LDs would provide an in-demand diagnostic tool if …