High-frequency stimulation of the subthalamic nucleus suppresses oscillatory β activity in patients with Parkinson's disease in parallel with improvement in motor …

AA Kühn, F Kempf, C Brücke, LG Doyle… - Journal of …, 2008 - Soc Neuroscience
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …

Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity

AA Kühn, A Tsui, T Aziz, N Ray, C Brücke… - Experimental …, 2009 - Elsevier
Parkinson's disease (PD) is associated with exaggerated oscillatory synchrony in the basal
ganglia at frequencies over 8–35 Hz. Studies have demonstrated a suppression of local field …

Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease

WJ Neumann, K Degen, GH Schneider… - Movement …, 2016 - Wiley Online Library
Objective Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a
pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study …

Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements

E Barow, WJ Neumann, C Brücke, J Huebl, A Horn… - Brain, 2014 - academic.oup.com
Deep brain stimulation of the globus pallidus internus alleviates involuntary movements in
patients with dystonia. However, the mechanism is still not entirely understood. One …

A localized pallidal physiomarker in cervical dystonia

WJ Neumann, A Horn, S Ewert, J Huebl… - Annals of …, 2017 - Wiley Online Library
Objective Deep brain stimulation (DBS) allows for direct recordings of neuronal activity from
the human basal ganglia. In Parkinson's disease, a disease‐specific physiomarker was …

Dopamine transporter (DAT) imaging in Parkinson's disease and related disorders

T Brücke, C Brücke - Journal of Neural Transmission, 2022 - Springer
This review gives an insight into the beginnings of dopamine transporter (DAT) imaging in
the early 1990s, focussing on single photon emission tomography (SPECT). The …

Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive compulsive disorder

WJ Neumann, J Huebl, C Brücke, L Gabriëls… - Molecular …, 2014 - nature.com
The role of distinct limbic areas in emotion regulation has been largely inferred from
neuroimaging studies. Recently, the opportunity for intracranial recordings from limbic areas …

[HTML][HTML] Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients

N Darcy, R Lofredi, B Al-Fatly, WJ Neumann… - Experimental …, 2022 - Elsevier
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …

Scaling of movement is related to pallidal γ oscillations in patients with dystonia

C Brücke, J Huebl, T Schönecker… - Journal of …, 2012 - Soc Neuroscience
Neuronal synchronization in the gamma (γ) band is considered important for information
processing through functional integration of neuronal assemblies across different brain …

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients

R Lofredi, L Okudzhava, F Irmen, C Brücke… - npj Parkinson's …, 2023 - nature.com
Pathologically increased beta power has been described as a biomarker for Parkinson's
disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we …