High-frequency stimulation of the subthalamic nucleus suppresses oscillatory β activity in patients with Parkinson's disease in parallel with improvement in motor …
AA Kühn, F Kempf, C Brücke, LG Doyle… - Journal of …, 2008 - Soc Neuroscience
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …
therapy for patients with severe Parkinson9s disease (PD), but its mechanism of action is …
Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
Parkinson's disease (PD) is associated with exaggerated oscillatory synchrony in the basal
ganglia at frequencies over 8–35 Hz. Studies have demonstrated a suppression of local field …
ganglia at frequencies over 8–35 Hz. Studies have demonstrated a suppression of local field …
Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease
WJ Neumann, K Degen, GH Schneider… - Movement …, 2016 - Wiley Online Library
Objective Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a
pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study …
pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study …
Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements
Deep brain stimulation of the globus pallidus internus alleviates involuntary movements in
patients with dystonia. However, the mechanism is still not entirely understood. One …
patients with dystonia. However, the mechanism is still not entirely understood. One …
A localized pallidal physiomarker in cervical dystonia
WJ Neumann, A Horn, S Ewert, J Huebl… - Annals of …, 2017 - Wiley Online Library
Objective Deep brain stimulation (DBS) allows for direct recordings of neuronal activity from
the human basal ganglia. In Parkinson's disease, a disease‐specific physiomarker was …
the human basal ganglia. In Parkinson's disease, a disease‐specific physiomarker was …
Dopamine transporter (DAT) imaging in Parkinson's disease and related disorders
T Brücke, C Brücke - Journal of Neural Transmission, 2022 - Springer
This review gives an insight into the beginnings of dopamine transporter (DAT) imaging in
the early 1990s, focussing on single photon emission tomography (SPECT). The …
the early 1990s, focussing on single photon emission tomography (SPECT). The …
Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive compulsive disorder
WJ Neumann, J Huebl, C Brücke, L Gabriëls… - Molecular …, 2014 - nature.com
The role of distinct limbic areas in emotion regulation has been largely inferred from
neuroimaging studies. Recently, the opportunity for intracranial recordings from limbic areas …
neuroimaging studies. Recently, the opportunity for intracranial recordings from limbic areas …
[HTML][HTML] Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
Scaling of movement is related to pallidal γ oscillations in patients with dystonia
C Brücke, J Huebl, T Schönecker… - Journal of …, 2012 - Soc Neuroscience
Neuronal synchronization in the gamma (γ) band is considered important for information
processing through functional integration of neuronal assemblies across different brain …
processing through functional integration of neuronal assemblies across different brain …
Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients
R Lofredi, L Okudzhava, F Irmen, C Brücke… - npj Parkinson's …, 2023 - nature.com
Pathologically increased beta power has been described as a biomarker for Parkinson's
disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we …
disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we …