Mutational heterogeneity in cancer and the search for new cancer-associated genes
Major international projects are underway that are aimed at creating a comprehensive
catalogue of all the genes responsible for the initiation and progression of cancer …
catalogue of all the genes responsible for the initiation and progression of cancer …
Genomic classification of cutaneous melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
[HTML][HTML] A landscape of driver mutations in melanoma
Despite recent insights into melanoma genetics, systematic surveys for driver mutations are
challenged by an abundance of passenger mutations caused by carcinogenic UV light …
challenged by an abundance of passenger mutations caused by carcinogenic UV light …
Integrated genomic characterization of papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
The somatic genomic landscape of chromophobe renal cell carcinoma
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell
carcinomas (ChRCCs) on the basis of multidimensional and comprehensive …
carcinomas (ChRCCs) on the basis of multidimensional and comprehensive …
Membrane-proximal epitope facilitates efficient T cell synapse formation by anti-FcRH5/CD3 and is a requirement for myeloma cell killing
J Li, NJ Stagg, J Johnston, MJ Harris, SA Menzies… - Cancer cell, 2017 - cell.com
Summary The anti-FcRH5/CD3 T cell-dependent bispecific antibody (TDB) targets the B cell
lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells. We demonstrate …
lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells. We demonstrate …
Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement
SH Lee, CE Le Pichon, O Adolfsson, V Gafner… - Cell reports, 2016 - cell.com
The spread of tau pathology correlates with cognitive decline in Alzheimer's disease. In vitro,
tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function …
tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function …
Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo …
SH Hausner, D DiCara, J Marik, JF Marshall… - Cancer research, 2007 - AACR
Expression of the epithelial-specific integrin αvβ6 is low or undetectable in most adult
tissues but may be increased during wound healing and inflammation and is up-regulated …
tissues but may be increased during wound healing and inflammation and is up-regulated …
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease
G Ayalon, SH Lee, O Adolfsson, C Foo-Atkins… - Science Translational …, 2021 - science.org
Tau has become an attractive alternative target for passive immunotherapy efforts for
Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate …
Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate …
Characterizing genomic alterations in cancer by complementary functional associations
Systematic efforts to sequence the cancer genome have identified large numbers of
mutations and copy number alterations in human cancers. However, elucidating the …
mutations and copy number alterations in human cancers. However, elucidating the …