Metagenomics is the study of microbial communities sampled directly from their natural
environment, without prior culturing. Among the computational tools recently developed for
metagenomic sequence analysis, binning tools attempt to classify the sequences in a
metagenomic dataset into different bins (ie, species), based on various DNA composition
patterns (eg, the tetramer frequencies) of various genomes. Composition-based binning
methods, however, cannot be used to classify very short fragments, because of the …

Metagenomics is the study of microbial communities sampled directly from their natural
environment, without prior culturing. Among the computational tools recently developed for
metagenomic sequence analysis, binning tools attempt to classify all (or most) of the
sequences in a metagenomic dataset into different bins (ie, species), based on various DNA
composition patterns (eg, the tetramer frequencies) of various genomes. Composition-based
binning methods, however, cannot be used to classify very short fragments, because of the …