One advantage of exploring the human DNA (De-oxyribonucleic acid) is the revelation of its contribution to many human diseases. In result of exploring the DNA, there were specific genes in specific chromosomes in the DNA that reveal Alzheimer's Disease (AD). Prognosis of AD helps in slowing down the progression of the disease considerably which is our main goal. AD is an irreversible progressive disease in the brain that slowly causes decline in the memory affecting the patient's life. AD can be detected by screening the WGS (Whole Genome Sequence) to search in specific genes that are responsible for detecting AD or by finding the mutations that happens in the SNPs (Single-Nucleotide Polymorphism) in these specific genes. This research applies two different approaches to study and analyze the DNA and compares them to each other to determine the most suitable approach regarding detecting AD. A dataset was imported and accommodated from The Alzheimer's Disease Neuroimaging Initiative (ADNI) used to implement our research. Our research obtained that using SNPs in studying and analyzing AD is faster and more reliable than using WGS.