The objective of this research is to propose and confirm a new machine learning approach of Best-First tree (BFtree), AdaBoost (AB), MultiBoosting (MB), and Bagging (Bag) ensembles for potential groundwater mapping and assessing role of influencing factors. The Yasuj-Dena area (Iran) is selected as a case study. For this regard, a Yasuj-Dena database was established with 362 springs locations and 12 groundwater-influencing factors (slope, aspect, elevation, stream power index (SPI), length of slope (LS), topographic wetness index (TWI), topographic position index (TPI), land use, lithology, distance from fault, distance from river, and rainfall). The database was employed to train and validate the proposed groundwater models. The area under the curve (AUC) and statistical metrics were employed to check and confirm the quality of the models. The result shows that the BFTree-Bag model (AUC = 0.810, kappa = 0.495) has the highest prediction performance, followed by the BFTree-MB model (AUC = 0.785, kappa = 0.477), and the BFTree-MB model (AUC = 0.745, kappa = 0.422). Compared to the benchmark of Random Forests, the BFTree-Bag model performs better; therefore, we conclude that the BFtree-Bag is a new tool should be used for modeling of groundwater potential.