This paper presents an adaptive model for developing disease registries. The proposed model is based on the Scrum methodology. It can be used to draw a road map to identify priorities, inputs, outputs, team members and exchanges for all tasks required to develop disease registries. Our model has been applied to real cases from several Tunisian hospitals where it has improved the efficiency of the team members. The developed disease registries are currently used in Tunisia. They allow medical researchers to identify origins of diseases, establish new protocols, perform surveys and compute morbidity.