This paper directly observe the impact of wind-sand factor on Photovoltaic (PV) panel. Taking into account the influence of this factor, based on the simulation of FLUENT, this paper simulates the situation of PV panels in the wind-sand two phases flow field. For a PV power generation system, sand and dust have the greatest impact, which not only block the PV panels, but also increase the temperature. Furthermore, it damage the surface of the panel, reducing its efficiency. The cleaning cycle of the PV panel is predicted by observing the accumulation of dust.