This paper focuses on the research of a new high-speed DC switch repulsion mechanism with experimental and simulation methods. Multi-physical equations reflecting the transient electromagnetic field, electric circuit, mechanical motion and material deformation are coupled in the calculation. For the reason of accuracy, skin effect and the proximity effect caused by the current in the coil are also taken into account. According to the simulation results, which indicate several key parameters severely affecting the mechanism speed, a high-speed DC switch repulsion mechanism is developed. By the test of mechanism motion, its average speed can be up to 8.4 m/s and its mechanism response time is 250 µs, which verifies the simulation results. Furthermore, during high speed motion the stress on the metal plate and moving contact is also discussed. It is noticed that the influence of the material deformation on the mechanical motion is very important.