As a core subtask in anaphora resolution, anaphoricity determination has aroused the interest of researchers. However, in recent work, the influence caused by the deep semantic information and the context of the coreference elements have not been taken into account. In this paper, by combining the semantic feature of Uygur, we established a Convolutional Neural Network & Long Short-Term Memory (CNN_LSTM) model in determining the anaphoricity of Uygur pronoun. Firstly, the deep negative semantic feature representation is extracted via word2vec. Secondly, the shallow explicit feature representation of coreference elements is extracted by our system. Afterwards, two kinds of features are combined to recognize whether coreference element is referential or not. The results showed that the method we used can distinguish coreference element accurately, the ACC score is 90.18% and the ACC score is 89.93%, which are higher than ANN (Artificial Neural Network) and SVM (Support Vector Machine) respectively.