Tumorigenesis is a multistep process characterized by a myriad of genetic and epigenetic
alterations. Identifying the causal perturbations that confer malignant transformation is a …

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To
identify pathways supporting the Myc oncogenic program, we used a genome-wide RNA …

Retroviral short hairpin RNA (shRNA)–mediated genetic screens in mammalian cells are
powerful tools for discovering loss-of-function phenotypes. We describe a highly parallel …

Tumors exhibit numerous recurrent hemizygous focal deletions that contain no known tumor
suppressors and are poorly understood. To investigate whether these regions contribute to …

The RE1-silencing transcription factor (REST, also known as NRSF) is a master repressor of
neuronal gene expression and neuronal programmes in non-neuronal lineages 1 , 2 , 3 . …

During tumorigenesis, tumors must evolve to evade the immune system and do so by disrupting
the genes involved in antigen processing and presentation or up-regulating inhibitory …

Genomics has provided a detailed structural description of the cancer genome. Identifying
oncogenic drivers that work primarily through dosage changes is a current challenge. …

Localization to sites of DNA damage is a hallmark of DNA damage response (DDR) proteins.
To identify DDR factors, we screened epitope-tagged proteins for localization to sites of …

Polyubiquitylation is canonically viewed as a posttranslational modification that governs
protein stability or protein-protein interactions, in which distinct polyubiquitin linkages ultimately …

Defects in chromosome–microtubule attachment trigger spindle-checkpoint activation and
delay mitotic progression 1 , 2 . How microtubule attachment is sensed and integrated into the …