The DNA damage response is a hierarchical process. DNA damage is detected by sensor
proteins such as the MRN complex that transmit the information to transducer proteins such as …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was …

Timely negative regulation of the immune system is critical to allow it to perform its duty while
maintaining it under tight control to avoid overactivation. We previously reported that the …

The DNA damage response is a key factor in the maintenance of genome stability. As such,
it is a central axis in sustaining cellular homeostasis in a variety of contexts: development, …

Human genomic instability syndromes affect the nervous system to different degrees of
severity, attesting to the vulnerability of the CNS to perturbations of genomic integrity and the …

ATM is one of the sentries at the gate of genome stability. This multifunctional protein kinase
orchestrates the intricate array of cellular responses to DNA double-strand breaks. Absence …

Parkinson's disease (PD) is a progressive neurological disease caused by selective
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Although PD …

Ataxia-telangiectasia (AT) is a genetic disorder caused by mutational inactivation of the
ATM gene. AT patients display a pleiotropic phenotype and suffer primarily from progressive …

: Shrinkage and collapse of the neuritic network are often observed during the process of
neuronal apoptosis. However, the molecular and biochemical basis for the axonal damage …

A form of learning in the marine mollusk Aplysia, long-term sensitization of the gill- and
siphon-withdrawal reflex, results in the formation of new synaptic connections between the …